Biomedical subjects
Publications and source records attributed to Rowena Johnston.
Some time within the next few weeks, VaxGen is expected to announce the results of the Phase III trials of its first vaccine candidate based on a bivalent HIV envelope gp120, AIDSVAX B/B. Interpretation of these results will probably not be straightforward and will likely lead to many more unanswered questions. Following is a description of some of the key issues involved.
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Given that an acquired immune deficiency syndrome (AIDS) vaccine is more likely to mitigate than avert human immunodeficiency virus (HIV) infection, prevention efforts are focused on the development of a microbicide to reduce the sexual transmission of HIV. In this context, a microbicide might take the form of a cream or gel applied topically prior to sexual intercourse to lower the risk of HIV transmission. The most recent advances in the development of an anti-HIV microbicide were discussed at the International Microbicides 2002 Conference, held in Antwerp, Belgium, from May 12-15, 2002. Highlights from the conference, including basic scientific, clinical, and social, political and economic aspects of microbicide development, are presented here.
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