Polycyclic polyprenylated acylphloroglucinols.
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Molecular Conformation↗
Biomedical subjects
Roxana Ciochina
Publications and source records attributed to Roxana Ciochina.
A new synthetic approach to the polycyclic polyprenylated acylphloroglucinols.
[reaction: see text] The three-carbon alpha,alpha'-annulation of a sterically hindered cyclic beta-keto ester can be achieved by alkynylation with 3,3-diethoxypropyne, syn reduction of the alkyne with Co(2)(CO)(8) and Et(3)SiH, and an intramolecular aldol reaction. The method is potentially useful for the synthesis of nemorosone, hyperforin, and other polycyclic polyprenylated acylphloroglucinols.
Alkynes↗