Biomedical subjects

Rudolf Guthoff

Publications and source records attributed to Rudolf Guthoff.

5 recordsLinked to original sources

PubMed2002

Monitoring accommodative ciliary muscle function using three-dimensional ultrasound.

BACKGROUND: Our objective was to develop a three-dimensional high-resolution ultrasonic imaging technique to be utilized for in-vivo characterization of the ciliary body and the posterior iris. The benefit of this imaging in enhancing the quantification of the configurational changes in the ciliary body during accommodation is demonstrated. METHODS: Sequential ultrasound biomicroscopic images of the ciliary body region were obtained with a computer-controlled scanning device designed for use with a standard ultrasound biomicroscope for 3D imaging. Custom-made software allows online data collection, data analysis and 3D reconstruction in conjunction with commercially available VoxelView software. RESULTS: The three-dimensional presentation allows a close approximation of the ciliary muscle inside the ciliary body in vivo. We are able to distinguish and to analyze the changes in the muscle contour in different accommodation states. During accommodation a shift in the ciliary muscle center of gravity in a range of 0.04-0.26 mm (mean 0.13+/-0.06 mm) in the direction of the lens equator, with an interindividual variation and a small decrease with age, was observed. CONCLUSIONS: High-resolution ultrasound is a well established technique for in-vivo investigation of the anterior segment. Three-dimensional ultrasound biomicroscopy allows an assessment of the individual ciliary muscle activity in consideration of the ciliary processes. In combination with a contour analysis tool we improved the muscle contour determination during different accommodation states. The investigation showed an activity of the ciliary muscle in young volunteers as well as those of presbyopic age.

Accommodation, Ocular↗

PubMed2002

Transscleral diode laser contact cyclophotocoagulation in the treatment of different glaucomas, also as primary surgery.

PURPOSE: To evaluate the clinical outcome of transscleral cyclophotocoagulation (TSCPC) with the diode laser for different glaucomas, especially as primary surgery. METHODS: A retrospective analysis of 250 TSCPC (193 eyes of 145 patients) with different glaucomas and an average age of 62.6+/-17.1 years. Postoperative follow-up ranged from 6 to 48 months (mean 13.9 months). Most of the patients had primary open-angle glaucoma (POAG) or secondary glaucoma. All eyes were treated with 24-30 spots and 1.4-1.8 W at an exposure time of 2 s using a diode laser with a focussing tip. RESULTS: The mean intraocular pressure (IOP) decreased from 24.6+/-6.7 mmHg before to 19.3+/-5.7 mmHg after operation ( P<0.001). The IOP was successfully controlled (final IOP 10-22 mmHg) in 76.4% of cases after a single or multiple TSCPC treatments. The reductions in maximal IOP and in the number and frequency of administration of antiglaucomatous drugs were also significant ( P<0.001). The best results were obtained among the patients with POAG, in the oldest age group and in those patients without any previous or subsequent glaucoma operations. The proportion of eyes requiring multiple treatments was 21.2%, with an average of 1.3 treatments per eye. There was a complication rate of 14.4%, mostly mild uveitis. Phthisis bulbi occurred in three eyes (1.6%). CONCLUSIONS: TSCPC with the diode laser is a safe, effective procedure to reduce the IOP in the treatment of different glaucomas with few severe complications. It is also suitable for primary surgical treatment.

Adolescent↗

PubMed2002

[Nasolacrimal duct obstruction caused by a cylindroma. Report of an atypical tumor manifestation and review of the literature].

BACKGROUND: The purpose of this report is to describe the clinical characteristics, management and histological findings in a patient with obstruction of the nasolacrimal duct caused by a cylindroma. About 618 lacrimal sac tumours have been reported previously in reviews and case reports, which were reviewed after searching in medline database. CASE REPORT: A 79-year old man suffered from multiple cylindromas (Spiegler tumour) on his head for about 40 years. He presented with a 6 months' history of left-sided epiphora and a painless medial canthal mass of various size. A tumour which caused nasolacrimal duct obstruction was found during dacryocystorhinostomy. After complete excision histological examination revealed a cylindroma, which had shown expansive growth from dermis to the lacrimal sac area. The patient felt well; there was no longer any epiphora or dacryocystitis after the operation. CONCLUSION: Although very rare, lacrimal sac tumours must be considered in the differential diagnosis of nasolacrimal duct obstruction. To our knowledge this case represents the first report on an atypical manifestation on a Spiegler tumour in the lacrimal sac region.

Aged↗

PubMed2002

[Glabellar transposition flap for medial canthal reconstruction after tumour excision].

BACKGROUND: We focussed on the suitability of a glabellar transposition flap for repairing medial canthal defects after tumour excision and also on a satisfactory cosmetic result. PATIENTS AND METHOD: Between July 1994 and November 1999 we supplied 11 patients with a glabellar transposition flap to repair a soft tissue defect in the medial canthal area. 4 patients with a histologically proven basalioma. 5 patients had a recurrence of basalioma, who had first been operated on elsewhere. One patient was suffering from a squamous cell carcinoma and one patient showed a scar epicanthus. In the following we describe the glabellar transposition flap. This method is available for the reconstruction of the medial canthus. We also mention other methods and combinations. RESULTS: No patient required a further operation. Good postoperative cosmetic and functional results were seen in all patients. CONCLUSIONS: The glabellar transposition flap is suitable for reconstructing the medial canthus. Our results suggested that this flap can be applied for the repair of defects measuring up to 30 x 25 mm. This method is also appropriate for deeper defects in this area. The flap is suitable if a patient has a recurrence of tumour.

Adult↗

PubMedDate not supplied

[Prof. Carl Wilhelm von Zehender (1819-1916)--first professor of ophthalmology and co-founder of the ophthalmological clinic at the University of Rostock--commemorative lecture at the 100th DOG meeting in Berlin from 26.9 to 29.9.2002].

The Grand-ducal University Eye Department in Rostock was solemnly inaugurated 16 May 1892. According to many years of studies in Europe and on efforts to build this clinic, construction was outlined by Professor Carl Wilhelm v. Zehender, but the drafts were executed by the "Grossherzoglich-Mecklenburgisch-Schwerinschen Medicinalcommission" and Landbaumeister Schlosser in winter 1888/89. Professor v. Zehender, who originated from a very ancient Swiss family, was born in Bremen, 21 May 1819. He studied medicine in Goettingen, Jena, Prague, Paris and Vienna. During this time he developed a lifelong friendship with Albrecht v. Graefe. 1856 he took over the medical care for the hereditary duke Georg von Mecklenburg-Strelitz and published the "Correspondenzblatt für Aerzte im Grossherzoglichen Mecklenburg-Strelitz". 1857, during a conference in Heidelberg, his initiative led in the long run to the establishment of the "Heidelberger Ophthalmologische Gesellschaft", the forerunner of the "Deutsche Ophthalmologische Gesellschaft", which was founded in 1920. In 1863 the first edition of "Klinische Monatsblaetter für Augenheilkunde" was published as a periodical; the cover page bore its name as the founder of the magazine. In 1866, after the death of the hereditary duke and a professorship in his hometown Berne, he became honorary professor of the Rostock University, and from 1869 onwards he chaired the clinic as a regular professor. After all his efforts to build his own hospital had failed, he demonstratively and finally resigned from his professorship in 1889. He went to Munich and became editor of the " Klinische Monatsblaetter für Augenheilkunde". In 1907 he moved with his wife via Eutin to Warnemuende. There the nestor of world ophthalmologists died at the age of 98. His burial place without gravestone is situated in today's landscape park "Stephan Jantzen". So far all efforts of the author and of the Rostock University Eye Department taken after 1980 to create a worthy note to this exceptional ophthalmologist in the Baltic Sea resort Warnemuende were unsuccessful, also for financial reasons. But on 2.9.2002 with the help of the Lighthouse Club of Warnemuende a memorial plaque to Prof. C. W. v. Zehender was mounted on the guest house "Margarete". This plaque commemorates Professor Zehender's merits in establishing the DOG, planning and building the eye clinic of the university of Rostock.

Germany↗