Biomedical subjects

Rune Jacobsen

Publications and source records attributed to Rune Jacobsen.

7 recordsLinked to original sources

PubMed2006

Cellular telephone use and cancer risk: update of a nationwide Danish cohort.

BACKGROUND: The widespread use of cellular telephones has heightened concerns about possible adverse health effects. The objective of this study was to investigate cancer risk among Danish cellular telephone users who were followed for up to 21 years. METHODS: This study is an extended follow-up of a large nationwide cohort of 420,095 persons whose first cellular telephone subscription was between 1982 and 1995 and who were followed through 2002 for cancer incidence. Standardized incidence ratios (SIRs) were calculated by dividing the number of observed cancer cases in the cohort by the number expected in the Danish population. RESULTS: A total of 14,249 cancers were observed (SIR = 0.95; 95% confidence interval [CI] = 0.93 to 0.97) for men and women combined. Cellular telephone use was not associated with increased risk for brain tumors (SIR = 0.97), acoustic neuromas (SIR = 0.73), salivary gland tumors (SIR = 0.77), eye tumors (SIR = 0.96), or leukemias (SIR = 1.00). Among long-term subscribers of 10 years or more, cellular telephone use was not associated with increased risk for brain tumors (SIR = 0.66, 95% CI = 0.44 to 0.95), and there was no trend with time since first subscription. The risk for smoking-related cancers was decreased among men (SIR = 0.88, 95% CI = 0.86 to 0.91) but increased among women (SIR = 1.11, 95% CI = 1.02 to 1.21). Additional data on income and smoking prevalence, primarily among men, indicated that cellular telephone users who started subscriptions in the mid-1980s appeared to have a higher income and to smoke less than the general population. CONCLUSIONS: We found no evidence for an association between tumor risk and cellular telephone use among either short-term or long-term users. Moreover, the narrow confidence intervals provide evidence that any large association of risk of cancer and cellular telephone use can be excluded.

Cell Phone↗

PubMed2006

Causes of death behind low life expectancy of Danish women.

AIMS: The authors examined causes of death contributing to the relatively high mortality of Danish women born 1915-45, and evaluated the impact of smoking related causes of death. METHODS: Age-period-cohort analysis of mortality of Danish women aged 40-89 in 1960-98. Estimate of the negative curvature in parabola patterns for 50 causes of death. RESULTS: A total of 34 causes of death contributed to the relatively high mortality for women born 1915-45. The main contribution came from smoking-related causes of death. CONCLUSION: The results indicate a high smoking prevalence to be the main explanation behind the relatively low life expectancy of Danish women born 1915-45.

Aged↗

PubMed2005

Trends in testicular cancer incidence in the Nordic countries, focusing on the recent decrease in Denmark.

Testicular cancer is the most frequent malignancy among young men, and there have been steady increases in its incidence in most western countries for many decades. Recently, a decrease was seen in some countries, including Denmark. Here, we report recent trends in testicular cancer incidence in the Nordic countries. We address the hypothesis that the causal factors for testicular cancer in Denmark are related to birth cohort and that non-seminoma and seminoma tumours have a common aetiology. An overall increase in testicular cancer incidence was found in the Nordic countries, corresponding to increases with each consecutive birth cohort in each country. In Denmark, a decline in incidence was observed during the past 5 years, and men born around 1943 and around 1968 showed lower incidences than men born just before or just after these dates. These birth-cohort effects were seen both for seminoma and non-seminoma tumours. This descriptive study confirms the hypothesis that birth cohort has a major influence on the incidence pattern of testicular tumours and suggests that seminoma and non-seminoma have common aetiological factors.

Cohort Studies↗

PubMed2004

Fertility pattern does not explain social gradient in breast cancer in denmark.

The present study was undertaken to assess the impact of reproductive behavior on the social class gradient in breast cancer occurrence in Denmark. Objectives were to study whether the gradient across socioeconomic groups could be explained by fertility differences, whether the gradient across educational groups could be explained by fertility differences and whether the effect of socioeconomic group on breast cancer incidence and mortality could be explained by education and vice versa. We studied 674,084 women aged 20-39 at the census on 9 November 1970 for whom we had complete data on fertility history. The cohort was followed up for breast cancer incidence and mortality until 8 November 1998. Fertility history varied considerably across socioeconomic group, where 38% of the academics were childless at the age of 30, in contrast to only 8% of women in agriculture. The academics had the highest risk of breast cancer and women in agriculture had the lowest risk. For incidence, the gradient in the relative risks was 1.74, which changed to 1.49 when fertility history was incorporated and to 1.29 when school education was also taken into account. For school education, women with > or = 12 years of schooling had the highest risk and women with < or = 7 years of schooling had the lowest risk. For incidence, the gradient in the relative risk was 1.38, which changed to 1.26 when fertility history was incorporated and to 1.22 when socioeconomic group was also taken into account.

Adult↗

PubMed2004

Violent behaviour among adolescents in Iceland: a national survey.

BACKGROUND: Violence among adolescents may have serious developmental, physical, and mental health consequences for the affected individuals. In this study, we assessed the prevalence of violent behaviour and its correlates among 15-16 year old schoolchildren in Iceland. METHODS: In 1997, a cross-sectional survey was conducted among a random half of all Icelandic schoolchildren aged 15-16 years. The overall response rate was 91% (N = 3872). In the present study, socio-demographic background, social support, negative life events, psychological distress, and substance use were considered in relation to violent behaviour using logistic regression techniques. RESULTS: The majority of the respondents reported having committed violence within the last year. Boys were more likely to use violence than girls (odds ratio [OR] = 5.6; 95% CI: 4.7, 6.6). Respondents who had experienced >/=4 negative life events in the past year were more likely to use violence than respondents with no negative life events (OR = 3.0; 95% CI: 2.2, 4.2). Smokers were more likely than non-smokers to use violence (OR = 1.7; 95% CI: 1.2, 2.2), and adolescents who had used alcohol >20x in their lifetime were more than twice as likely to commit violence compared with those who had never used alcohol (OR = 2.5; 95% CI: 1.8, 3.4). CONCLUSION: Rates of violent behaviour among Icelandic schoolchildren were high. Gender, parental support, life stress, anger/aggression, and substance use were all significantly related to the perpetration of violent acts.

Adolescent↗

PubMed2004

Women's death in Scandinavia--what makes Denmark different?

OBJECTIVE: To compare the mortality for women in Sweden, Norway and Denmark in order to search for clues for the low life expectancy of Danish women. METHODS: Prospective age-period-cohort study covering 40 years for all Swedish, Norwegian and Danish women aged 40-84 during the period 1960-2000, and born 1900-1950. OUTCOME MEASURES: Relative risks and 95% confidence intervals for deaths. RESULTS: The high risk of dying among Danish women was associated with being born between the two World Wars, and that a similar pattern was not found for women in Norway and Sweden. A tendency of a cohort effect was observed for Swedish women born around 1940. CONCLUSIONS: The currently low life expectancy of Danish women compared with that of women in Norway and Sweden is partly a transitional phenomenon caused by excessive death rates for women born between the two World Wars. Data on smoking prevalence by birth cohort and age indicate that a high percentage of Danish women in these cohorts were smokers throughout their adult life.

Adult↗

PubMed2004

Use of census data for construction of fertility history for Danish women.

BACKGROUND: Modern epidemiology increasingly uses data on families. The authors constructed an extended fertility database for women born in Denmark from 1930 onwards by supplementing the existing Fertility Database with household data from the 1970 census. METHODS: A fertility history was constructed for all women participating in the 1970 census, but aiming for complete data only for women aged 20-39. The fertility history of these women prior to the 1970 census was constructed from the census data including 1,648,813 persons coded as children. An algorithm was used transforming household information into fertility history data by matching women and children according to family position. Children for whom the algorithm gave no match were searched for in the Fertility Database; children not found in the Fertility Database either were searched for manually. The fertility history after the 1970 census was retrieved from the Fertility Database. RESULTS: Using data from the census 1970, 98.5% of the children were linked to a mother, and 99.6% of these links were estimated to be correct, corresponding to 98.1% of the children being linked correctly. In total, 964,720 children of women aged 20-39 in 1970 were identified, which was equivalent to 96.6% of the expected live-born children, and to 99.1% of the expected surviving children. CONCLUSION: Census household data proved to be an excellent data source for construction of fertility histories.

Adult↗