Biomedical subjects

Russell A Chipman

Publications and source records attributed to Russell A Chipman.

6 recordsLinked to original sources

PubMed2006

Oxyhemoglobin saturation measurements by green spectral shift.

From an analysis of new hemoglobin solution transmission spectra at various oxygen saturations (SO2), path lengths, and pH, we find the determination of SO2 by using the classical oximetry technique to be poorly calibrated. We used this data set to develop a proposed method for SO2 determination based on the spectral shift of the hemoglobin transmission minimum between 475 and 510 nm. The method does not require accurate knowledge of hemoglobin extinction coefficients and is linear in relation to SO2 despite changes in path length, pH, or hemoglobin concentration.

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PubMed2006

Polarimetric characterization of liquid-crystal-on-silicon panels.

Mueller matrix imaging polarimetry of liquid-crystal-on-silicon (LCoS) panels provides detailed information useful for the diagnosis of LCoS problems and to understand the interaction of LCoS panels with other projector components. Data reduction methods are presented for the analysis of LCoS Mueller matrix images yielding contrast ratio, efficiency, spatial uniformity, and the calculation of optimum trim retarders. The effects of nonideal retardance, retardance orientation, and depolarization on LCoS system performance are described. The white-state and dark-state Mueller matrix images of an example LCoS panel are analyzed in terms of LCoS performance metrics typical for red-green-blue wavelengths of 470, 550, and 640 nm. Variations of retardance, retardance orientation, and depolarization are shown to have different effects on contrast ratio, efficiency, and brightness. Thus Mueller matrix images can diagnose LCoS problems in a way different from radiometric testing. The calculation of optimum trim retarders in the presence of spatial variations is discussed. The relationship of the LCoS retardance in single-pass (from front to back) to the double-pass retardance (from entrance to exit) is established and used to clarify coordinate system issues related to Mueller matrices for reflection devices.

Journal Article↗

PubMed2005

Depolarization of diffusely reflecting man-made objects.

The polarization properties of light scattered or diffusely reflected from seven different man-made samples are studied. For each diffusely reflecting sample an in-plane Mueller matrix bidirectional reflectance distribution function is measured at a fixed bistatic angle using a Mueller matrix imaging polarimeter. The measured profile of depolarization index with changing scattering geometry for most samples is well approximated by an inverted Gaussian function. Depolarization is minimum for specular reflection and increases asymptotically in a Gaussian fashion as the angles of incidence and scatter increase. Parameters of the Gaussian profiles fitted to the depolarization data are used to compare samples. The dependence of depolarization on the incident polarization state is compared for each Stokes basis vector: horizontal, vertical, 45 degrees, 135 degrees, and right- and left-circular polarized light. Linear states exhibit similar depolarization profiles that typically differ in value by less than 0.06 (where 1.0 indicates complete depolarization). Circular polarization states are depolarized more than linear states for all samples tested, with the output degree of polarization reduced from that of linear states by as much as 0.15. The depolarization difference between linear and circular states varies significantly between samples.

Journal Article↗

PubMed2005

Depolarization index and the average degree of polarization.

Two single number metrics for depolarization of samples are contrasted: (1) the average degree of polarization of the exiting light averaged over the Poincaré sphere and (2) the depolarization index of Gill and Berbenau [Opt. Acta 32, 259-261 (1985); 33, 185-189 (1986)1. The depolarization index is a geometric measure that varies from 0 for the ideal depolarizer to 1 for nondepolarizing Mueller matrices. The average degree of polarization also varies from 0 to 1 and characterizes the typical level of depolarization. Although the depolarization index is very often close to the average degree of polarization, these two metrics can differ by more than 0.5 for certain Mueller matrices.

Journal Article↗

PubMed2004

First- and second-order polarization mode dispersion generated by a two-stage emulator.

A two-stage polarization mode dispersion (PMD) emulator design consisting of two variable delay lines separated by a rotatable half-wave linear retarder is analyzed and shown to generate an adjustable amount of first- and second-order PMD without any higher orders. This two-stage PMD emulator configuration provides a simple easy-to-breadboard solution for second-order PMD emulators. When compared with PMD emulators based on birefringent crystals, this two-stage emulator is simpler to calibrate.

Journal Article↗

PubMedDate not supplied

Retinal oximetry using intravitreal illumination.

PURPOSE: To demonstrate spectroscopic retinal oximetry measurements on arteries and veins in swine using intravitreal illumination. Retinal arterial and venous saturations are measured for a range of inspired O2 levels after pars plana vitrectomy. METHODS: Pars plana vitrectomy and intravitreal manipulations were performed on two female American Yorkshire domestic swine. Light from a scanning monochromator was coupled into a fiberoptic intraocular illuminator inserted into the vitreous. The retinal vessels were illuminated obliquely, minimizing vessel glints. Multispectral images of the retinal vasculature were obtained as the swine's arterial blood oxygen saturation was decreased from 100% to 67% in decrements of approximately 10%. Retinal vessel spectra were used to calculate oxygen saturation in selected arteries and veins. Arterial oxygen saturations were calibrated using blood gas analysis on blood drawn from a Swan-Ganz catheter placed in the femoral artery. RESULTS: Oblique illumination of retinal vessels using an intravitreal fiberoptic illuminator provided a substantial reduction in the central vessel glint usually seen in fundus images, thus simplifying the analysis of spectral data. The vessel shadows were displaced from the vessel image simplifying the light paths in the eye. Using a full spectral analysis simplified by the light path reductions, we calculated retinal vessel saturations. The reduction of glint allowed for increased accuracy in measuring retinal vessel spectral optical density. Abnormally low retinal venous oxygen saturations were observed shortly after pars plana vitrectomy. CONCLUSIONS: Retinal oximetry using intravitreal illumination has been demonstrated. As a research tool, intravitreal illumination addresses several difficulties encountered when performing retinal oximetry with transcorneal illumination.

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