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S A Auelbekov

Publications and source records attributed to S A Auelbekov.

2 recordsLinked to original sources
PubMedDate not supplied

[Antiviral activity of derivatives of aldehydophenols, aldehydo- naphthols and sugar derivatives].

The antiviral activity of aldehydrophenol, aldehydonaphthol derivatives and sugar derivatives was studied. The compounds in doses of 150-500 micrograms/ml were shown to reduce the viral infectious activity by 1.5-3.3 lg TCD50/ml. The degree of virus activity inhibition by the synthesized compounds indicates the relationship of the chemical structure with the antiviral effect of these compounds.

Animals↗
PubMedDate not supplied

[DNA-binding proteins in human serum].

Fractions of acid and base blood serum proteins, separated by ion exchange chromatography on QAE-Sephadex (but not the proteins of the whole blood serum, which had the same charge), reacted with DNA preparations. Separate fractions of blood serum proteins were able to react with DNA after electrophoretic separation. Binding of blood serum proteins with DNA did not depend on ion strength within the range of NaCl concentration from 0.1 M to 0.5 M; it was also stable at pH 5.5 = 8.0. Interaction between acid DNA-binding proteins and native DNA was inhibited by denatured DNA, polyguanilic and polyinosinic acids and by other polyanions: dextran sulfate, polyvinyl sulfate, polyanetol sulphonate, polystyrol sulphonate and heparin. Acid DNA-binding proteins showed only a slight affinity to polyadenilic, polyuridilic and polycytidilic acids. The acid and base DNA-binding proteins appear to be contained in blood serum in the form of a loosely bound complex.

Blood Proteins↗