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Biomedical subjects

S A Beardsworth

Publications and source records attributed to S A Beardsworth.

6 recordsLinked to original sources
PubMed1999

Premature greying of the hair is not associated with low bone mineral density.

In two recent case-control studies premature greying of the hair was associated with a lowering of bone mineral density (BMD) and osteopenia, suggesting that this might be a clinically useful risk marker for osteoporosis. We report a further re-examination of this proposal in 52 prematurely grey-haired women from East Yorkshire who responded to an advertisement inviting them for bone densitometry. Thirty-five had no clinical or drug history that could influence bone density. All were Caucasian with a mean age of 52.8 years. In the group as a whole the mean BMD values at the lumbar spine and femoral neck were no different from those of a young adult, but there was a trend toward a greater than average BMD than that of the local age-matched population (p = 0.097 and 0.218, respectively). Twenty women were premenopausal, with an average age of 45.3 years. Mean BMD values at the lumbar spine and femoral neck in this group were no different from those of young adults. There was, however, a trend toward a BMD greater than that of the local age-matched population at the femoral neck (p = 0.117). Fifteen women were postmenopausal with an average age of 62.9 years and an average age at menopause of 51.1 years. Mean BMD values at both the lumbar spine and femoral neck in this group were lower than those of young adults, but no different from those of the local age-matched population. In conclusion, our group of prematurely grey-haired women had average BMD for their age, and we are therefore unable to support the proposed clinical usefulness of premature greying as a risk marker for osteoporosis.

Absorptiometry, Photon↗
PubMed1999

Prevention of postmenopausal bone loss at lumbar spine and upper femur with tibolone: a two-year randomised controlled trial.

OBJECTIVE: To examine the effects of tibolone on bone mineral density and its concurrent safety and subject acceptability. DESIGN: Prospective randomised controlled study. SETTING: Centre for Metabolic Bone Disease, Hull. POPULATION: Forty-seven healthy post-menopausal women aged 50-57 years with normal bone mineral density at lumbar spine. METHODS: Bone mineral density was assessed every 24 weeks at lumbar spine and proximal femur using dual energy X-ray absorptiometry. RESULTS: The bone mineral density of the tibolone treated subjects tended to increase while those of the controls tended to fall. The higher densities in the tibolone group were significant at lumbar spine from week 24 (P = 0.002) and at the trochanter from week 72 (P = 0.014). The lower bone densities in the controls were significant at Ward's Triangle and femoral neck at week 96 (P < 0.0001), and at lumbar spine from week 24 onwards (P < 0.05). Between-treatment analysis indicated that, by the 96th week, the bone densities at all sites in the tibolone group were significantly different from those in the control group. At the lumbar spine the differences were highly significant throughout the study (P < 0.0004). Four women receiving tibolone withdrew from the study due to unacceptable adverse events. Two women withdrew from the control group. There was no significant difference between the groups in the number of subjects suffering adverse experiences. Vaginal bleeding occurred in seven women, all from the tibolone treated group, resulting in one withdrawal from the study. CONCLUSION: Tibolone is thus an effective and well-tolerated alternative to oestrogen in the prevention of osteoporosis with its beneficial effects being most apparent at the lumbar spine.

Absorptiometry, Photon↗
PubMed1999

Comparison of accuracy and cost effectiveness of clinical criteria and BUA for referral for BMD assessment by DXA in osteoporotic and osteopenic perimenopausal subjects.

A pilot study of 107 women aged 60-69 years recently suggested that the measurement of broadband ultrasound attenuation (BUA) provides a superior cost effective pre-screen referral method for bone mineral density (BMD) measurement by DXA (dual-energy X-ray absorptiometry) than can be achieved by clinical criteria (CC). The aim of this study was to compare the accuracy and cost effectiveness of BUA and clinical criteria in a younger cohort. 599 women aged 50-54 years (52.18 +/- 1.35) had previously been measured by DXA at lumbar spine and right femoral neck, along with BUA measurement of the right calcaneus. Each subject had also completed an extensive clinical and social questionnaire to ascertain those who would have met one or more of the six general clinical criteria adopted by our Centre. Each subject was classified by DXA using the WHO criteria as normal, osteopenic or osteoporotic, defined at lumbar spine or femoral neck. Sensitivity, specificity and accuracy were calculated for BUA and the clinical criteria, noting that analysis was undertaken with and without the oestrogen deficiency clinical criterion (CC1): "Any oestrogen deficient woman who would want to be treated or would want to continue treatment if found to be osteopenic or osteoporotic". The accuracy for identifying osteoporotic subjects was 72.8% for BUA (at the point of matched sensitivity and specificity, 75 dB MHz(-1)), 30.7% for CC(1-6) and 64.3% for CC(2-6). When osteopenic subjects were incorporated, the accuracies were 63.8% for BUA (at the point of matched sensitivity and specificity, 82 dB MHz(-1)), 60.3% for CC(1-6) and 55.7% for CC(2-6). The minimum cost per osteoporotic subject correctly identified was pound sterling 573.50 by DXA alone, pound sterling 325 by BUA, pound sterling 458 by CC(1-6) and pound sterling 416 by CC(2-6). When osteopenic subjects were incorporated, the costs were pound sterling 87, pound sterling 83.50, pound sterling 78 and pound sterling 74, respectively. The overall cost, dependent upon the prevalence of osteoporosis (or osteopenia) within the population, more accurately indicates the feasibility of a population-based screening programme. For the identification of either osteoporotic or osteopenic subjects from the general population by DXA, the prevalence-compensated cost (cost per subject correctly identified multiplied by prevalence) is pound sterling 45, irrespective of age cohort. If CC(2-6) were adopted for the identification of osteoporotic subjects alone, the prevalence-compensated cost would be pound sterling 32 and pound sterling 42 for the 50-54 and 60-69 aged cohorts, respectively. For BUA, the prevalence-compensated cost falls to pound sterling 25 and pound sterling 43 for the 50-54 and 60-69 aged cohorts, respectively. If osteoporotic or osteopenic subjects were to be identified in the 50-54 aged cohort, both CC(2-6) (pound sterling 38) and BUA (pound sterling 43) perform similarly to DXA alone. BUA appears to provide a valuable population pre-screen for the identification of osteoporotic subjects, less so for osteopenic. It is suggested that if both osteopenic and osteoporotic women are to be identified for clinical management incorporating DXA, then neither BUA nor clinical criteria are satisfactory referral methods. An unanswered question from this study, however, is whether ultrasound has an independent role in the assessment of fracture risk for perimenopausal women who do not have the benefit of referral for DXA.

Absorptiometry, Photon↗
PubMed1994

Prolonged pregnancy: two years experience of offering women conservative management.

A prospective study of 199 patients over a two year period, 1 Jun 90 to 31 May 92 at the Louise Margaret Maternity Wing, Cambridge Military Hospital, Aldershot was undertaken to audit the uptake of an offer of conservative management of prolonged pregnancy to women at 42 weeks gestation. The labour outcomes of patients opting for conservative or induction management plans were recorded and the increased workload introduced to the Ultrasound Unit measured. Of the 91/199 (45.7%) patients who chose to be managed conservatively, 20 (22.0%) developed an abnormal result of a test of fetal surveillance, 16 (17.6%) were electively delivered because of an abnormal result. There were no significant differences in labour performance or neonatal outcome between those women opting for conservative management or induction of labour. 201 new ultrasound scans were booked, 129 were performed (0.4 scans/week/1000 deliveries).

Adolescent↗