Biomedical subjects
Publications and source records attributed to S A Burov.
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The effectiveness of amantadine hydrochloride as a prophylactic against influenza was studied during an epidemic caused by viruses related to influenza A2/Hong Kong/1968 variants in Leningrad, USSR, early in 1969. In all, 8169 subjects, assigned to amantadine-dosed, placebo-dosed, internal control and external control groups, were assessed. The index of effectiveness of the prophylactic medication, based on clinical diagnosis, in subjects who took amantadine regularly was 1.95. When the clinical diagnoses were confirmed serologically the index of effectiveness for the amantadine compared with the placebo group increased to 2.7. A comparison of the medicated group with the non-medicated, non-isolated internal control group showed an index of effectiveness of 5.34. A daily dose of 100 mg of amantadine was associated with an increase of 1.14% in complaints of sleep disturbances but these had no effect on the working capacity of subjects.
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The emergence of neuroimaging techniques and new surgical technologies (neuroendocopy, navigation systems) in neurosurgery has substantially changed views of surgery for traumatic intracranial hematomas. The local fibrinolytic technique that has been applied to 40 victims aged 18 to 67 years (mean age 42.1 +/- 2 years) who had 18-to-97-cm3 hematomas is a promising direction of mini-invasive surgery for traumatic intracranial hematomas in patients in the compensated and subcompensated state. There were 32 males and 8 females. The procedure of the surgical intervention involves drainage of intracranial hematoma, followed by clot lysis and liquid blood aspiration along the drainage. A good outcome with a complete hematoma removal and clinical symptom regression was observed in 26 patients, a fair result with preservation of moderate neurological symptoms at hospital discharge was noted in 2 patients; 3 victims died. Recurrent bleedings were seen in 4 patients with epidural hematomas. A morphological study revealed the typical features of the morphogenesis of traumatic hematomas and perifocal brain tissue during local fibrinolytic therapy, which suggests that the area of damaging effect of bleeding on the adjacent brain tissue is decreased. Local fibrinolysis in surgery of traumatic intracranial hematomas may be considered to be one of the promising lines of treatment policy along with the existing traditional and current techniques and may be used as the method of choice in surgery of traumatic intracranial hematomas in patients in the compensated state. Removal of epidural hematomas through local fibrinolysis should be limited due to a high risk of recurrent hemorrhage and may be made only in a restricted contingent of patients with severe concomitant injury and concurrent somatic diseases when the risk of combined anesthesia and that of a longer operation are rather high. Moreover, of promise is that subtentorial epidural hematomas may be aspirated without trepanation of the posterior cranial fossa and the surgery may be performed under local anesthesia.
Hydrocortisone and 6-methylprednisolone increase the binding constant of anilinenaphthalene-sulphonate (ANS) with the cytoplasmatic thymocytes membrane following a 2--3 hour long incubation in vitro. Over the same period these compounds stimulate the liberation of potassium ions from the thymocytes. A supravital staining of the thymocytes with Trypan blue did not change during the whole time of the hormones action. The effect of the hydrocortisone and 6-methylprednisolone action on the ANS binding constant and potassium release depende upon the duration of incubation and concentration of the steriod in the medium. Hydrocortisone produces a greater influence than does 6-methylprednisolone.
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