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Biomedical subjects

S A Estrem

Publications and source records attributed to S A Estrem.

25 records · Page 2Linked to original sources
PubMed1988

Topical vital staining of human squamous cell carcinoma xenografts in nude mice.

We propose a method for visually enhancing residual cutaneous carcinoma in excision sites using topical stains. Utilizing nude mice, topical stains were applied to fresh wound beds containing partially resected human squamous cell carcinoma xenografts. Fifteen of 18 tumors were visually enhanced using topical 1% acridine orange and ultraviolet light, while none of the seven tumors stained with 0.25% dihematoporphyrin ether and ultraviolet light were enhanced. Of the stains tested, only acridine orange proved to visually enhance tumor tissue in a fresh wound bed. This study establishes the concept of direct wound staining as an aid in the excision of cutaneous cancers.

Acridine Orange↗
PubMed1988

Motor-evoked potentials of facial musculature in dogs.

Motor responses of limb musculature have been elicited by transcranial brain stimulation using electrical and magnetic stimulation. Recording from muscles innervated by cranial nerves has not previously been reported. A unilateral hemispheric craniotomy was performed in 24 dogs. An electric stimulus was delivered directly to the exposed motor cortex via surface electrodes. Evoked electromyographic responses to motor cortex stimulation were recorded from the contralateral orbicularis oculi and orbicularis oris muscles. Preliminary investigation into the use of magnetic stimulation of the motor cortex is compared to direct electrical cortical stimulation. This study demonstrates the potential for magnetic stimulation in the intraoperative and outpatient clinical evaluation of facial nerve disorders. It appears possible, for the first time using magnetic stimulation, to noninvasively stimulate these nerves proximal to the point of injury and to evaluate more central conduction pathways.

Animals↗
PubMed1988

Skin tolerance and adaptation following implantation of the Xomed Audiant bone conductor.

Placement of the Xomed Audiant implantable bone conduction hearing prosthesis was initially restricted to a limited number of investigators. It was introduced to other otolaryngologists in a workshop on August 15-16, 1986. There have since been several workshops offered by Xomed and Dr. Hough, who developed the device, to train otolaryngologists how to implant this device. The literature thus far is limited to the experience of Hough and others involved with his initial trials. He has not reported any significant complications associated with this device. The purpose of this paper is to communicate a complication resulting from the use of this device. Skin ulceration over the implant resulted from excessive use of the hearing prosthesis within 2 weeks of the initial fitting. Other contributing factors in the breakdown of skin will be discussed along with suggestions regarding prevention.

Aged↗
PubMed1987

Implantation of human keloid into athymic mice.

In the interest of developing an animal model for keloids, human keloid dermis was implanted in the subcutaneous tissues of athymic (nude) mice. Subsequent growth resulted in a lesion with histology similar to the original keloid. Fibroblasts were cultured from keloid dermis. When the fibroblasts alone were implanted in the subcutaneous tissues of nude mice, growth of a visible lesion was again produced. The fibroblasts had proliferated and deposited collagen in an abnormal fashion with the histology resembling the parent keloid. Further research could develop this into a reliable animal model to allow in vivo experimentation.

Adult↗
PubMed1987

Disorders of smell and taste.

This article describes the anatomy and physiology of the gustatory and olfactory organs in man. Dysfunction of these senses is closely examined with respect to etiology, diagnosis, and treatment. Taste and smell are closely interrelated. An influence on the function of one sense often affects the function of the other sense.

Humans↗
PubMedDate not supplied

Cis-diamminedichloroplatinum (II) ototoxicity in the guinea pig.

Cochleas from 12 guinea pigs were evaluated using light, scanning, and transmission electron microscopy after systemic administration of cis-diamminedichloroplatinum (cis-DDP). Administration of cis-DDP resulted in loss of the Preyer reflex and degeneration of outer hair cells (OHC) with increased dose. The OHC degeneration was most pronounced in the basal turns of the cochlea with greatest severity in the inner row. Ultrastructural evidence of OHC degeneration included dilatation of the parietal membranes, softening of the cuticular plate, increased vacuolization and increased numbers of lysosome-like bodies in the apical portion of the cell. Supporting cells appeared more sensitive than OHC. Alteration of supporting cell ultrastructure preceded detectable change in OHC. Injury to the supporting cells was noted with intracellular vesiculation and increased autophagocytosis.

Animals↗