Biomedical subjects

S A Gasparian

Publications and source records attributed to S A Gasparian.

At least 19 recordsLinked to original sources

PubMed1997

[Analysis of ordinary microbial relationships in human colonic dysbacteriosis].

A relationship between the qualitative and quantitative characteristics of representatives of the normal microflora in biocenosis of the colonic lumen (CL) was studied in 18 patients with subacute bacterial endocarditis, 18 patients with rheumatic heart disease, 13 with chronic renal failure and 50 healthy individuals without clinical signs of dysbacteriosis. The number of intermicrobial relationships was found to be rather small both in health and in disease. However, a disease shows a considerably greater number of different relations, synergic ones in particular. Analysis indicated that in the conditions under study 72 to 93% of relations that were realized in the healthy human CL biotope disappeared and the established intermicrobial relationships were found 86-97% quite new. Summing up, the authors have concluded that, first, the CL microflora exists under the conditions of excess nutrient substrate and is not a factor of self-regulation, second, changes in the body's metabolic systems are primary in the diseases examined, which the normal lumenal microflora is responsive to.

Adolescent↗

PubMed1994

[The computer diagnosis and prognosis of emergency states in neurology].

The authors provide the analysis of long-term experience gained in the field of devising and introduction of diagnostic algorithms adjusted for various mathematical approaches and aimed for resolving of clinical tasks in vascular and somatogenic impairments of the nervous system. Basic requirements have been formulated for effective use of the diagnostic tables. The authors suggest to compare on the training sample diverse mathematical methods in order to define most effective of them in each case. The application of artificial file of observations is important to determine maximum accuracy of the diagnostic system. An advantage of multivariate statistical methods is demonstrated in clinical decisions on the treatment of somatogenic nervous diseases.

Algorithms↗

PubMed1993

[Prognosis and daily evaluation of changes in the condition of patients with peritonitis].

The authors examined 159 patients with peritonitis (87 with the generalized form and 72 patients with the diffuse form) and conducted a statistical analysis of the findings. Quantitative and some qualitative parameters of the patients were studied. The Student and Wilcoxon criteria and the correlation and discriminant analysis were used in construction of the determinative rules. Two groups of discriminant functions were constructed to obtain the prognosis of the outcome of peritonitis in a patient with daily appraisal of the dynamics of changes in his condition. The first group of prognostic indices was obtained only from the qualitative data. The second group of "simplified" prognostic indices was constructed with the use of parameters which are used most frequently in the wide clinical practice. The quality of both groups of discriminant functions proved to be comparable, i. e. both sets of determinative rules may be used in medical practice to evaluate the condition of a patient with peritonitis and construct the prognosis of the outcome of the disease.

Adolescent↗

PubMed1990

[Elaboration and use of the methods of computer-assisted diagnosis of cerebrovascular pathology].

The purpose of the work was to analyze the experience with the trial of diagnostic algorithms to specify possibilities of differential diagnosis and forecasting the course or outcome of cerebrovascular diseases. Detailed study of 922 clinico-anatomic cases (547 with hemorrhagic brain stroke, 157 with ischemic, 218 with pseudostroke) enabled revealing differential-diagnostic criteria for the pathological patterns under study bearing in mind disease pathomorphism. Analysis was made of the tabular diagnosis of cerebrovascular pathology and of the experience gained with the trail of diverse diagnostic algorithms for staged diagnosis of brain stroke and pseudostroke, different varieties of cerebral hemorrhages (10 varieties). The results of the use of four algorithms for forecasting hemorrhagic brain stroke were studied and compared. The accuracy of the diagnosis and forecasting amounts from 55 to 82.3% depending on the problem to be solved and the algorithm used. The data show the necessity of the careful providing of the algorithm choice as dependent on the problem raised.

Adult↗

PubMed1983