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Biomedical subjects

S A George

Publications and source records attributed to S A George.

10 recordsLinked to original sources
PubMed1992

Liquid formulations of 8-methoxypsoralen (8-MOP) and 5-MOP: a prospective double-blind crossover assessment of acute non-phototoxic adverse effects.

Thirty-nine patients with psoriasis undergoing PUVA participated in a prospective double-blind study of acute non-phototoxic adverse effects comparing the liquid formulations of 8-methoxypsoralen (0.6 mg/kg) and 5-methoxypsoralen (1.2 mg/kg). A much higher number of patients experienced nausea (8-MOP = 51.3%, 5-MOP = 7.7%) and pruritus (8-MOP = 71.8%, 5-MOP = 43.6%) than has been reported for crystalline tablets. No attempt was made to compare therapeutic efficacy between liquid and crystalline tablet formulations or between 8-MOP and 5-MOP, which both appeared to be effective. The high incidence of adverse effects suggests that current dosage recommendations be reviewed.

5-Methoxypsoralen↗
PubMed1979

Bilateral pulmonary resection for bronchiectasis: a 40-year experience.

Ninety-nine patients underwent bilateral pulmonary resection for severe multisegmental bilateral bronchiectasis at the Overholt Thoracic Clinic during the period 1937 to 1977. A total of 216 operations were performed, and 20 patients underwent three or more procedures. The operative mortality was 1.4% and the incidence of severe complications, 7%. Follow-up ranged from 1 to 30 years (average 10.2 years). Only 1 patient was lost to follow-up. Improvement in pulmonary symptoms was achieved in 83 patients; there was no improvement in 9 patients; and 4 patients were worse following resection. The results suggest that bilateral bronchiectasis need not be a contraindication to operation. In properly selected patients, lasting symptomatic improvement can be provided by resection.

Adolescent↗
PubMedDate not supplied

Venturi grafts for hemodialysis access.

Vascular access grafts can produce venous and puncture site stenosis, and excessive shunted flow. A vascular access graft that controls the shunted flow at 500-650 ml/min by venturi flow resistance, and offers the potential for reduced venous stenosis, is presented. Twelve venturi grafts consisting of 6 mm ePTFE, with a thermally formed venturi resistance, were implanted in a canine femoral arterio-venous (A-V) model and cannulated for simulated dialysis for periods up to 6 months. Pressures, bleeding times, and puncture site healing were compared at sites upstream and downstream of the venturi. Nine 6 mm ePTFE grafts were implanted as controls. Venturi and control graft patency rates were similar: 90% for venturi grafts and 89% for control implants at 4 months. Measurements verified pressure dissipation by the venturi from 85 to 15 mmHg, delivering near-normal pressures to the vein; downstream pressures were 22 mmHg higher in controls. Sites downstream of the venturi did not bleed at 4 min, whereas bleeding was often noted after 9 min at other sites. Puncture sites upstream of the venturi had less stenosis and less mural thrombus than sites downstream of the venturi, and compared favorably with puncture sites in the control grafts. This improved healing and low pressure delivery to the vein may offer clinical advantages.

Animals↗