PubMed Health⌕ Search

Biomedical subjects

S A Grachev

Publications and source records attributed to S A Grachev.

25 records · Page 2Linked to original sources
PubMedDate not supplied

[Decrease of toxic effects of aminothiol radiation-protective agents and increase of chemical protection action against ionizing radiation by the use of unithiol].

It has been shown that unithiol diminishes toxic action of cysteamine, AET, and disulfide of WR-1065 on mice. This permits to enhance protection of animals against X-rays by increasing of protector doses. The effect of unithiol on cysteamine action in rats was the same. Antitoxic effect of unithiol on cysteamine was shown both at i.p. and p.o. protector administration. The effect was also revealed in Chinese hamster V-79 cell culture. Combined disulfide of cysteamine and unithiol was synthetized, which ensures effective prolonged protection against ionizing radiation.

Animals↗
PubMedDate not supplied

[Experience in the search of new prolonged-action radiation-protective agents].

The cysteamine derivative-guanidinoethanesulfanylthiosulfuric acid was demonstrated to have radioprotective properties protecting mice against X-rays and fission neutron irradiation hazard. Radioprotective efficacy shows itself for 2 hours after i.p. and p.o. administration of the preparation. It was established an opportunity of the prolonged protective action of gammaphos as a result of its cross-linking to dextran. The preparation has a radioprotective action on X-ray and neutron irradiation.

Amifostine↗