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Biomedical subjects

S A Iakimenko

Publications and source records attributed to S A Iakimenko.

At least 19 recordsLinked to original sources

[Phonophoresis of the proteolytic enzymes lekozim or kollalizin in the combined therapy of eye burns].

A two-stage phonophoresis of proteolytic enzymes of lecozim or collalysine was used in a complex treatment of severe eye burns. The main group of patients consisted of 20 patients (23 eyes) treated by lecozim phonophoresis and 6 patients (6 eyes)--by collalysine phonophoresis. The control group consisted of 23 patients (25 eyes) treated by a complex treatment without phonophoresis of proteolytic enzymes. The comparative analysis of the course of a burn disease in both groups has shown positive influence of enzyme therapy on its dynamics and outcome. In the main group, the arrest of inflammatory signs accomplished earlier (by the 27th-29th day) as compared with the control group (by the 32nd-38th day) as well as epithelialization of corneal defects (by the 27th-30th day and by the 34th-42nd day, respectively); earlier vascularization of the cornea stimulated improvement of the burn process. Of a characteristic feature of the treatment was resolution of corneal opacification that began already after the first stage and continued within the second stage of the treatment. This allowed to achieve higher functional results. In the main group, visual acuity rose in 88.5%, and in the control--in 48% of patients.

Chymopapain↗

[Experimental validation of the use of RNA hydrolysate (ENKAD) in chemical burns of the cornea].

The influence of ENKAD on the course of a severe alkaline burn of the cornea was studied in 158 rabbits (316 eyes). Cytochemically, regularity in correlations of separate amino acids: cystin, cysteine, arginine and glutaminic acid in cellular proteins of the intact cornea was established and their disorder in dynamics of the burn process is shown. Comparative assessment of therapeutic effectiveness of ultrasound, applications, subconjunctival injections and phonophoresis of ENKAD has shown that a combined usage of ultrasound and ENKAD has the most expressed positive action on the course of the burn process of the corneal burn, such as acceleration of corneal epithelialization that accomplished, on the average, by the 9.3 +/- 0.3 day (in the control--by the 20.8 +/- 1.8 day), rapid disappearance of its perifocal edema--11.05 +/- 0.7 (in the control - 29.7 +/- 1.1) day, better outcomes after the burn (in 37.5% of cases superficial limited opacifications were formed, in the control--in 7.1%). One of the factors of therapeutic action of ENKAD phonophoresis is its normalizing influence on disturbed correlation of amino acids in proteins. The results obtained allow to recommend to include ENKAD phonophoresis into a complex treatment of patients with eye burns.

Animals↗

[The use of lekozim phonophoresis for the treatment of eye burns].

Experimental investigations concerning the influence of lecozyme phonophoresis on the development of a burn process in the eye have shown that lecozyme phonophoresis has a positive action on the development of a burn process, speeds up the stoppage of inflammatory signs, epithelialization and vascularization of the cornea, stimulates the formation of its less intensive opacifications. The most favourable term to use lecozyme phonophoresis is the second day after the moment of a burn trauma. To achieve a positive effect, 5 procedures are enough, while a longer course or treatment or later terms for its usage (7, 14, 21 days after burn) impairs the development of the burn process. The usage of lecozyme phonophoresis in two stages (5 sessions within the first day and 10 sessions after epithelialization of the cornea) allows to achieve the best results--stoppage of inflammatory signs, reduction of vascularization and opacifications of the cornea.

Animals↗