Antifibrinolytic therapy and pulmonary thromboembolism during orthotopic liver transplantation.
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Biomedical subjects
Publications and source records attributed to S A Irefin.
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For over 30 years, dialysis has been accepted as a proven therapeutic intervention in sustaining life for patients with end-stage renal disease. As a renal replacement therapy, dialysis only approximates renal function. Derangements in fluids, electrolytes, and acid-base homeostasis occur in the course of progressive renal insufficiency. Nephrons are able to adapt to physiologic needs and maintain a balance for many solutes, until the very late stages of chronic renal failure. This permits survival of the patient with minimal therapeutic intervention. The availability of highly permeable membranes has allowed development of continuous renal replacement therapies that gradually remove fluids and solutes resulting in better hemodynamic stability.
IMPLICATIONS: We report a case of a patient who developed membranous tracheal disruption after severe vomiting. He subsequently required urgent colectomy for toxic megacolon under general anesthesia. With this challenging situation, we were able to successfully conduct general anesthesia in the presence of tracheal laceration, pneumothorax, and pneumomediastinum.