Biomedical subjects
S A Lauter
Publications and source records attributed to S A Lauter.
The relationship between C-reactive protein and systemic lupus erythematosus.
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Pachydermoperiostosis: studies on the synovium.
Pachydermoperiostosis (primary hypertrophic osteoarthropathy) is a familial disorder characterized by clubbing, periosteal bone changes, and furrowing of the skin. A 40 year old male with this syndrome and chronic arthritis was recently studied. The synovial fluid was non-inflammatory. Histologically the synovium exhibited hyperplasia and microvascular alterations. Immunofluorescent staining failed to identify deposits of immunoglobulin. Electron microscopy revealed multilayered basement laminae around small subsynovial blood vessels but no electron-dense deposits as described in studies of hypertrophic pulmonary osteoarthropathy. The pathogenesis is obscure and appears to be non-immunological.
Homozygosity for HLA-B27 in psoriatic arthritis and spondylitis.
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