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Biomedical subjects

S A Oranskaia

Publications and source records attributed to S A Oranskaia.

11 recordsLinked to original sources
PubMed1993

[Age factors in natural mechanisms of detoxication and curative effect of enterosgel in burns].

In the experiment, the age peculiarities of the detoxication system of the liver in burn disease and the effect of enterosgel on them were studied. Decrease in hydroxylase and demethylase activity of hepatic microsomes in relatively stable activity of oxidoreductase as well as increase in activity of aminotransferases, especially that of alanine aminotransferase, which was more pronounced in aged animals, was noted. Under the influence of enterosorption, the increase in functional activity of monooxygenase system of the liver and stabilization of hepatocytic membranes are more pronounced in young animals. This contributed to reduction in lethality, activation of natural mechanisms of detoxication and reparative processes.

Age Factors↗
PubMed1990

[Effectiveness of geriatric preparations containing natural metabolites in studies on animals of different age].

The new geriatric agent Rikavit which contains natural metabolites, is described. Experimental trials have shown that this drug causes prolongation of the average and maximal life-span and normalization of the age-related changes in metabolic indices in experimental animals. It has also been found to increase the resistance of an aging organism to the hazardous effects (hypoxia, physical and medicamentous loads) and its adaptive potentials.

Adaptation, Physiological↗
PubMedDate not supplied

[Study of pharmacological activity of potassium glutamate in an experiment on young and old animals].

It was established that potassium glutaminate is a little toxic compound (LD50 amounts to 4500 mg/kg on administration to white mice by mouth) and shows a marked pharmacological activity. Administration of potassium glutaminate to white rats in a dose 500 mg/kg raises intracellular potassium level in the tissues, makes the acid-balance equilibrium return to normal after unilateral nephrectomy and acid load, activates bile-forming and choleretic liver function, exerts a moderate diuretic effect. The compound potentiates the activity of succinate dehydrogenase and cytochromoxidase in the tissues of old rats.

Acid-Base Equilibrium↗
PubMedDate not supplied

[Antianemic effect of ampevit and orkomin].

The antianemic action of ampevit and orkomin developed at the Laboratory of Experimental Therapy, Institute of Gerontology, Academy of Medical Sciences of the USSR was studied in experiments on young and old animals. It has been established that repeated administration of the drugs increases the reticulocyte count in both groups of animals. Ampevit diminishes severity of posthemorrhagic anemia. Both drugs promote more rapid recovery of hemoglobin content and red cell count in old animals after blood loss. The data obtained were supported by clinical trials of the drugs which have been recommended for combined treatment of posthemorrhagic anemias and other conditions accompanied by weakened function of the growing red fiber of the bone marrow seen also in people of old and senile age.

Age Factors↗
PubMedDate not supplied

[Age-related characteristics of the effect of potassium glutamate on cell membranes].

The effect of potassium glutaminate on the activity of some enzymes and lipid peroxidation of liver and kidney endoplasmic reticulum membranes was studied in young and old rats. It was shown that in old animals, the drug increased the activity of enzymes of liver endoplasmic reticulum membranes which metabolize the substances of endogenous and exogenous origin, and reduced the renal content of malonic dialdehyde, the final product of lipid peroxidation. The latter favoured the improvement of drug biotransformation and elimination of the aging body.

Aging↗
PubMedDate not supplied

[Age-related characteristics of potassium glutamate pharmacokinetics].

Experiments on young and old rabbits and rats were made to study the age-associated features of the pharmacokinetics of a new drug--potassium glutamate developed at the Laboratory of Experimental Pharmacology, Institute of Gerontology, Academy of Medical Sciences of the USSR. The age-associated differences in some pharmacokinetic parameters of potassium glutamate were disclosed: an increase in the half-life, a decrease in the overall clearance and a reduction in the elimination coefficient, an increase in the extent of distribution and area of the pharmacokinetic curve in old animals. A correlation was found between the pharmacokinetic parameters and drug pharmacological activity in animals of different age groups. The use of the pharmacokinetic data made it possible to calculate the optimal doses and to develop the schemes of effective application of potassium glutamate for young and old animals, as well as to extrapolate the experimental data to the drug clinical trials.

Aging↗