Head injury prognosis: calculations from clinical data.
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Apnea↗
Biomedical subjects
S A Parker
Publications and source records attributed to S A Parker.
The bleaching of the bacteriorhodopsin chromophore by ionizing radiation.
The visible chromophore of bacteriorhodopsin, BR(570), undergoes progressive bleaching when subjected to 60CO gamma-irradiation. The low G-value for bleaching confirms that the site of the chromophore is highly protected. Positive and negative circular dichroic (CD) bands associated with the chromosphone undergo concomitant decrease in a manner which is consistent with two independent chromophores rather than exciton coupling between neighbouring chromophoric site.
Bacteriorhodopsins↗
Memory recovery after traumatic coma.
Serial memory testings of 108 head injury cases were studied over a two year follow up period. The length of the post-traumatic disorientation period (PTD) was found to be an important factor in the rate of memory recovery. In the first year after injury marked differences were seen in the recovery rates of all four PTD groups, the three short PTD groups (less than one month) finally yielding from 74% to 92% cases (according to the group) with normal memory function, while the long PTD group (more than one month) only produced 45% cases (statistical significance 0.05). During the second year and up to the end of this survey relatively little change in memory status occurred in any of the cases, regardless of their PTD. Any improvement that did occur was at an extremely slow rate. Brain damage was the main cause of memory defect in the long PTD group, while anxiety symptoms had a more important role in the short PTD cases. The shapes of memory recall curves were analysed in recovering patients. Three types of curve were found. The incidence of the shape of the curve also varied according to the PTD time (statistical significance 0.05) between long and short PTD groups. Curve shapes are discussed in terms of memory mechanisms, and a possible prognostic value is suggested. Analysis of test errors indicated not only a defective transfer of material from short term long term memory storage but also in some cases, a more complex mechanism involving inappropriate fixation of attention. Reverberation of memory traces is suggested as being a possible cause of interference in both short and long term memory mechanisms. A marked difference in recall performance between auditory and visual presentation of word lists was found to be a useful lateralising sign.
Adolescent↗
The blink reflex in coma and after recovery from coma.
Comparative studies of the blink reflex in a series of head injuries through the stages of coma and recovery from coma in a series of miscellaneous hemispheral lesions, and in a normal series, reveals that, although the principal centre for the R1 component of the blink reflex seems to be localised in the upper pons, the seat of the R2 late component is in the reticular system. The reappearance of this late component of the blink reflex in our cases of coma although seeming to depend on the integrity of the mesencephalic formation, correlates with the recovery of the patient's alertness. On the other hand, habituation of this reflex depends on the integrity of global cognitive function, rather than on any localised centre. The roles of the cortex, selective attention, and emotional factors, are discussed. The recovery of the normal habituation of the blink reflex obtained by glabellar tapping was found to be a useful sign in the follow up of patients recovering from concussion and other lesions, such as subdural haematomas and brain tumours, with global mental impairment.
Adult↗