Tertiary pinta: case reports and overview.
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Adult↗
Biomedical subjects
S A Pecher
Publications and source records attributed to S A Pecher.
Lobomycosis (keloidal blastomycosis): case reports and overview.
Lobomycosis is a deep fungal disease of the skin without involvement of internal organs or mucous membranes. The disease is characterized by skin nodules and plaques resembling keloid involving the earlobes, distal parts of the upper and lower extremities, and buttocks. In severe cases, large skin areas can be covered by disseminated or grouped and confluent nodules. Most cases are reported from South and Central America. The fungus Paracoccidioides (Glenosporella) loboi is abundant in lesions but is extremely difficult to culture. Lobomycosis is resistant to chemotherapy, but in some cases it can successfully be treated by excision. Although the diagnosis is easily established by its typical clinical, histologic, and microbiological features, it is often misdiagnosed by physicians not familiar with the disease. We describe here five patients and present an overview of this rare disease.
Adult↗
[Immunology of tertiary pinta].
We've studied the immunological performed of twenty two natives Tikunas suffering from tertiary pinta. Among those, patients had been treated previously (two years earlier) which 2,400,000 IU of G benzathine penicillin, and twelve had no treatment. Both groups demonstrated an increment in the IgM synthesis (72.72%), IgG (50%), indicating the presence of strong antigenic stimuli. The great majority presenting a negative response revealed also a reduction in the cellular immune competence to at least two of the tests performed (92.3%), when were realized the PPD, DNCB and skin grafts tests.
Humans↗
[Histopathological aspects of tertiary pinta].
A study was made of twenty-two biopsies of achromic lesions of Tikuna Indians, carriers of tertiary pinta, inhabitants of the Umariuassu island, on the Peruvian border, ten of the subjects had been treated two years previously with a single dose of penicillin. The histopathological picture was similar for both groups. In most cases (86.36%) slight hyperkeratosis was found on the epidermis, as well as acanthosis (18.18%), with atrophy in only two cases (9.09%). In all cases there was a reduction of the melanin of the basal layer. The inflammatory lymphocyte infiltrate was predominantly perivascular (88.18%). There wasn't any endothelial swelling.
Biopsy↗
[Prevalence of superficial mycoses in the adult population of the Brazil-Colombia frontier].
A microbiological study was performed in the adult population of tier Brazil-Colombia, a very damp place with warm weather. It was observed a higher prevalence of P. versicolor (41.5%) and candidiasis (28.09%), followed by P. hortai and E. floccosum. The T. Tonsurans was the principal agent of the trichophitics of the hair. It's a higher prevalence of superficial mycosis was observed in the male.
Brazil↗
[Anemophilus fungi in the Brazilian-Colombian border].
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Air Microbiology↗
Anemophilus fungi in the western Brazilian Amazon basin.
The prevalence of anemophilus fungi was studied in three small towns located at the Brazilian border with Colombia and Venezuela (a hot and humid zone) during the month of July. On a single collection carried out in different spots, colonies were cultivated which could be attributed to eighteen different species of anemophilus fungi with predominance of Mucor (64%), Candida (55%), Rhodotorula (38%) and Penicillum (38%). The alternaria species, a very potent airbone allergen, was found only in one of the three collection spots with high prevalence of respiratory tract allergies.
Air Microbiology↗
Cellular immunity in lobomycosis (keloidal blastomycosis).
The cellular immune response of twelve patients from the Brazilian Amazon basin with lobomycosis were assessed. Delayed skin reaction to bacterial and fungal antigens, skin allograft rejection, and sensitization to dinitrochlorobenzene were studied. Ninety-two percent of the patients were not reactive to dinitrochlorobenzene after sensitization; skin allograft rejection occurred in an average of 17 days. Delayed skin reaction to streptococcal, staphylococcal, trichophytin and candida antigens was negative in the majority of the patients. Reactivity to mycobacterial antigens, however, was very high. The results suggest that patients with lobomycosis are partially cellular immunodeficient.
Aged↗
Study of humoral and cellular immunity in lobomycosis.
Fourteen patients with lobomycosis from the Amazon Basin were studied in order to assess their humoral and cellular immunological responses. The humoral response was normal, as shown by the normal levels of serum immunoglovulins. The cellular immunity was depressed for recent sensitizations as measured by skin contact test with DNCB (negative in 83.3% of 12 patients). The intradermal reactions to PPD and fungal extracts suggested that all patients were able to respond to at least 2 of the antigens used. It was also observed that patients reacting to PPD did not become sensitized to DNCB. Conversely, some Mantoux negative patients had positive reactions to DNCB. Both tests were negative in 3 patients.
Antibody Formation↗