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Biomedical subjects

S A Pridmore

Publications and source records attributed to S A Pridmore.

17 recordsLinked to original sources

Long term secure care in Tasmania.

The aim was to determine the requirement in Tasmania for long term (greater than 28 days) secure ward beds, and to characterise the patients who use them. There was complete enumeration over an 18 month period. The results included that 3.6 long term secure beds were used per 100,000 general population. Compared to those who were discharged during the survey, those who were not discharged were older, had spent longer in psychiatric hospitals and were more likely to be male and to suffer from schizophrenia. All patients were white Australians. The conclusions included that for planning purposes a minimum of 4.6 long term secure beds was required per 100,000 general population. Also, Aboriginal people and people from non-English speaking backgrounds were not over represented in long term secure care in Tasmania. Finally, "good" and "poor" prognosis groups were identified and further work is required to determine how these can best be managed.

Adult

The fertility of HD-affected individuals in Tasmania.

A study was conducted of the fertility (number of live births) of Huntington's disease (HD)-affected individuals compared to that of the general population using data from the 1986 Census of Population and Housing. HD-affected individuals were found to be at least as fertile as members of the general population. This finding supports earlier studies.

Birth Rate

Relative fertility of unaffected siblings of the Huntington's disease families of Tasmania.

The relative fertility of the unaffected siblings of the Huntington's disease families of Tasmania (compared with that of the general population) is calculated to be 0.87. Evidence suggests that these people resolve to restrict their family size. Antenatal testing would allow them the freedom of choice regarding family size which the general population currently enjoys.

Choice Behavior

The large Huntington's disease family of Tasmania.

This article presents data on the large Huntington's disease (HD) family of Tasmania. Nine generations have been traced, starting with the father of the woman who brought the disease to the State. From that woman, six lines have living affected descendants. There are 765 living descendants who are "at risk" of HD. The numbers of affected males and females are equal. Affected members of the family have a mean age of onset of HD of 48.6 years and a mean age of death of 61.8 years. Affected members are at least as fertile as members of the general population. Late-onset disease is associated with significantly greater fertility (in men more so than women) compared with that of unaffected siblings of the same sex. Men with late-onset disease had a significantly older mean age of reproduction than that of their unaffected male siblings, and they had significantly more offspring than the number calculated for the general population of Tasmania. Unaffected siblings produced fewer offspring than in the general population.

Age Factors

Reproduction and age of onset of Huntington's disease in Tasmania.

This study demonstrates that in Tasmania, individuals born before 1930, with an onset of Huntington's disease (HD) after the mean age of onset, were significantly more fertile than their unaffected siblings and the general population. This applied to both sexes. The mean parental age of men with late-onset disease was significantly greater than that of their unaffected male siblings. The clinical implication is that those individuals at 50% risk of late-onset HD who have achieved their desired family size should be offered sterilisation.

Age Factors

The prevalence of Huntington's disease in Tasmania.

This is the first field study to determine the prevalence of Huntington's disease in Tasmania. It is based on almost complete enumeration of affected individuals as of January 1, 1990. The prevalence was found to be 12.1 per 100,000, which is somewhat below the figure often attributed to Tasmania but about twice that of the accepted average in Occidental populations.

Confidence Intervals

Age of onset of Huntington's disease in Tasmania.

Various aspects of the age of onset of Huntington's disease (HD) were studied using extensive Tasmanian data. The mean age of onset of those born before 1930 was determined. For the total Tasmanian population of HD sufferers, this was 48.3 years. This finding has clinical implications because the most dangerous period for "at risk" individuals is frequently stated to be between 20 and 45 years. The range of age of onset for one very large Tasmanian family (the "Brothers family") is 53 years, from the second to the seventh decade. There were no juvenile-onset cases (onset before 20 years of age) in patients born in Tasmania before 1930. Three juvenile cases have occurred in those born since 1930. Support was found for the observation of paternal transmission in juvenile-onset HD. No support was found for the observation of maternal transmission in late-onset disease (50 years and beyond).

Adolescent

Age of death and duration in Huntington's disease in Tasmania.

The records of all Huntington's disease affected individuals born in Tasmania were examined. An age of birth exclusion criterion (only those born before 1928 were accepted) removed some bias in the determination of duration of illness and age of death. The mean age of death was at least 62.9 years. This is the oldest mean age of death reported for any geographical region. The sex of the affected individual and the sex of the transmitting parent did not significantly influence the mean age of death. The children of affected women lived to a greater age than theri mothers and the children of affected men died at a younger age than their fathers, but statistical significance was not achieved. The duration of the disease was 14.8 years.

Age Factors

Demonstrating the fibular collateral ligament.

A posture is described which allows palpation of the fibular collateral ligament of the knee as an isolated structure. Visual identification is also possible. This is of interest to the clinician and student of surface anatomy.

Fibula

A new cricothyrotomy cannula.

A simple, easily constructed cricothyrotomy cannula and its method of use are described. Experiments have demonstrated that the instrument admits adequate air to sustain life without causing trauma to the posterior laryngeal wall. The dimensions allow the concurrent use of the FG10 suction catheter. An accessory device which enables single instrument cricothyrotomy is also described.

Catheterization

Elastofibroma dorsi.

A case of bilateral subscapular elastfibroma dorsi in a 60-year-old woman is described. The striking clinical and pathological features of this rare benign tumour-like lesion are described and illustrated.

Female

Total blood lead levels in petrol vendors.

The total blood lead levels of a group of 48 petrol vendors and a comparison group of 47 clerks and students were determined. The mean total blood lead level of the petrol vendors was 32-9 mug/100 ml (S.E.1-73 mug/100 ml). The mean level of the comparison group was 14-3 mug/100 ml (S.E. 0-72 mug/100 ml). The concentrations of lead in the blood of petrol vendors were significantly higher than those of the comparison group, and seven individual values fell above the currently accepted "level of concern". Recent relevant literature is reviewed.

Adolescent