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Biomedical subjects

S A Rosenbloom

Publications and source records attributed to S A Rosenbloom.

17 recordsLinked to original sources
PubMed1991

Alternating sequential intracarotid BCNU and cisplatin in recurrent malignant glioma.

The authors entered 43 patients with recurrent malignant glioma in a trial of alternating sequential intracarotid BCNU and cisplatin. Protocol design was alternating courses of BCNU (2 doses, 300 to 400 mg each) and cisplatin (2 doses, 150 to 200 mg each) each at 4-week to 6-week intervals. Eight of 40 patients (20%) evaluable after the first course of BCNU showed partial or minor response. Only 18 patients were evaluable after the first course of cisplatin, and 5 were evaluable after the second course of BCNU. Median survival was 9 months (range, 2 weeks to 6 years). Cerebral or ocular toxicity unique to this method of chemotherapy administration and failure to show clinical improvement were the most common reasons for removal from study. Because of the high attrition rate, the authors were unable to determine a meaningful response to alternating sequential BCNU and cisplatin or to test the clinical degree of cross-resistance to these agents in human malignant glioma.

Adult↗
PubMed1991

Thoracic disc disease and stenosis.

Disc herniation and stenosis in the thoracic spine are relatively uncommon compared with their occurrence in the cervical or lumbar spine. They are usually degenerative, although trauma may be an aggravating or initiating factor. The clinical presentation includes local and/or radicular pain with or without signs and symptoms of cord dysfunction. Radicular pain may be secondary to mechanical compression or vascular impingement. MR imaging is the best way to define the specific abnormality as well as the effect on the adjacent spinal cord. CT after myelography may be useful as well, especially in those patients in whom there is involvement of the posterior ligamentous and osseous structures of the thoracic spinal canal. MR imaging may finally reveal the true incidence of thoracic disc herniation.

Humans↗
PubMed1989

Three-dimensional surface rendering of nasal anatomy from computed tomographic data.

This article investigates the potential of using three-dimensional surface-rendered computed tomographic reconstructions for demonstrating normal and pathologic intranasal anatomy. Three-dimensional surface renderings of the intranasal structures were generated in 38 patients from coronal high-resolution computed tomographic images. Because of the complex anatomy, three-dimensional images were believed to be useful for surgical planning. There may be a correlation between the appearance of the uncinate process and severity of inflammatory sinus disease.

Humans↗
PubMed1987

The preoperative venogram in planning extended craniectomies.

A technique of extended craniectomy sometimes allows removal of large central or transtentorial mass lesions at a single operative sitting because it affords better exposure and control of normal structures. While seeking to avoid multiple craniotomies, this method requires permanent ligation of the transverse venous sinus. Unless there is adequate collateral venous drainage from the ipsilateral hemisphere, the patient is at risk for venous infarction in the post-craniectomy period. The purpose of this study is to propose a method of establishing the presence of collateral venous drainage preoperatively. Each carotid artery is injected with the head in a neutral position and with the head turned to the side ipsilateral to the carotid artery injection in an attempt to divert the venous flow. Fifty patients were examined using this method; seven were being evaluated for possible craniectomies. The technique identified nine patients with potential venous collaterals (20%). They would otherwise have been considered nonoperable: two of the six patients eventually operated upon (33%) fell into this category. In general, the operative procedure may be safe more often on the left than the right (45%) vs (20%). Particular attention must be given to the pattern of venous drainage from the posterior temporal lobe to avoid isolation of the venous drainage from this area.

Adult↗
PubMed1983

Peripheral middle lobe syndrome.

Classically, the middle lobe syndrome has been described as being caused by a central obstruction. Clinical records and radiologic findings were reviewed in 129 patients examined between 1955-1981 who had chronic disease in the right middle lobe and/or lingula. Fifty-eight patients (45%) had no evidence of a central obstructive lesion. The majority were middle-aged women with histories of chronic cough and chest pain. Bronchoscopic and radiologic evaluation served to exclude central lesions. Surgical confirmation was available in 38 patients. Pathologic study showed varying degrees of chronic inflammation, pneumonia, and bronchiectasis. Surgical results were excellent in isolated disease. Chronic atelectasis and pneumonitis of the right middle lobe and/or lingula do not always imply central obstruction. A lack of collateral ventilation is a plausible theory to explain the pathophysiology in such patients.

Bronchiectasis↗
PubMedDate not supplied

Magnetic resonance of intracranial epidermoids.

The magnetic resonance images of seven patients with biopsy-proven epidermoids were evaluated. The epidermoids were hypointense on T1-weighted images. Intermediate density images revealed the tumors to be heterogeneous in signal intensity consisting of areas of hypo- and isointensity. Signal intensity on T2-weighted images was hyperintense and inhomogeneous in all but one case. CT performed in five patients demonstrated the tumors to be well-defined hypodense lesions without contrast enhancement.

Adolescent↗
PubMedDate not supplied

Temporomandibular joint chondrosarcoma: CT demonstration.

Chondrosarcoma of the temporomandibular joint is a rare lesion. A 49-year-old woman presented with painless left preauricular swelling. Computed tomography demonstrated a soft tissue mass in the left temporomandibular joint with extraarticular extension along the mandibular ramus. Calcification was present in the extraarticular component.

Chondrosarcoma↗
PubMedDate not supplied

The Sturge-Weber syndrome: comparison of MR and CT characteristics.

Four patients with Sturge-Weber syndrome were evaluated with CT and MR. MR demonstrated the characteristic features of the disease: cerebral atrophy (four patients), ipsilateral bone and sinus hypertrophy (three), ocular findings (one), intracranial calcification (four), prominent deep venous system (three), and enlarged choroid plexus (two). CT demonstrated the following: cerebral atrophy (four), ipsilateral bone and sinus hypertrophy (three), calcification (four), gyral enhancement (two), prominent deep venous system (two), and enlarged choroid plexuses (three). The features of Sturge-Weber syndrome were visualized equally well with MR and CT with the exception of intracranial calcification. Conventional spin-echo MR revealed fewer calcifications, and those visualized appeared smaller than with CT. Gradient-echo acquisition sequences were more effective in the detection of intracranial calcification.

Adolescent↗
PubMedDate not supplied

Cranial postoperative site: MR imaging appearance.

The ability to diagnose adverse postcraniotomy or postcraniectomy events is essential for proper postoperative care. The importance of identifying postoperative changes on CT has previously been shown. The purpose of this study is to assess the normal and abnormal MR changes that may be seen in the postcraniotomy/postcraniectomy period. The postoperative MR, CT, and medical records of 41 postcraniotomy patients and 26 postcraniectomy patients were reviewed. Reasons for choosing craniectomy over craniotomy included decompression, infected flap, bony involvement by tumor, and posttraumatic skull. In general, the postoperative normal anatomy was better seen with MR. Postoperative events included hemorrhage (two), infection (five), cyst formation (10), and recurrent tumor (five). In general, MR was found to be more useful than CT for the detection of hemorrhage and infection after craniotomy or craniectomy and for the proper localization of postoperative cysts. MR proved to be a useful method for following postoperative sites in the skull.

Craniotomy↗
PubMedDate not supplied

The significance of asymmetry of the foramen of Vesalius.

The foramen of Vesalius is a small, variable but consistently symmetrical structure located anteromedial to the foramen ovale and lateral to the foramen rotundum and vidian canal. It transmits an emissary vein through which the cavernous sinus and pterygoid plexus communicate. Fifty high-resolution CT scans of the skull base and two three-dimensional (Cemax) reconstructions were reviewed to determine criteria for defining the normal appearance of the foramen of Vesalius. Three normal types were classified: (1) a well-formed foramen, 1-2 mm in size (n = 32); (2) lack of visualization of the foramen (n = 11); and (3) partial assimilation of the foramen with the foramen ovale (n = 7). The foramen was remarkably symmetric in a large number of cases (n = 48). Asymmetry signified abnormality in four of the six cases. Abnormal causes of asymmetry included invasion by nasopharyngeal melanoma, angiofibroma, carotid cavernous fistula with drainage through the emissary vein, and neurofibromatosis. Thus, for these usually symmetric foramina of Vesalius, asymmetry is more likely the result of a pathologic process than a normal variant.

Arteriovenous Fistula↗