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Biomedical subjects

S A Sacks

Publications and source records attributed to S A Sacks.

At least 19 recordsLinked to original sources
PubMed1983

Ruder syndrome. Clinical and pathologic correlation.

Ruder syndrome is an unusual varient of adrenal hyperfunction characterized clinically by debilitating osteopenia, and pathologically by bilateral micronodular adrenal hyperplasia. A unique case resembling Ruder syndrome is described in which the dominant pathologic feature was unilateral adrenal adenomatosis.

Adenoma↗
PubMed1981

Testicular tumors of germ cell origin. 1. Epidemiology, pathogenesis, clinical presentation, and diagnosis.

Germinal testicular tumors occur in all age-groups but are most prevalent in men 20 to 34 years old. Tumor development has been associated with incompletely descended testis, "dysgenetic" testis, tumor in the contralateral testis, and trauma. Testicular tumor most often presents as a painless enlargement and induration. Examination should be meticulous and thorough. Any testicular or scrotal mass should be considered neoplastic until proven otherwise. When a testicular or intrascrotal mass presents a diagnostic dilemma, the lesion should be explored through an inguinal exposure. This surgical maneuver spares the patient an unnecessarily long and uncertain follow-up.

Adolescent↗
PubMed1981

Testicular tumors of germ cell origin.

Testicular tumors may be classified as seminoma, embryonal carcinoma, teratocarcinoma, teratoma, and choriocarcinoma. Staging is valuable to determine the extent and natural progression of disease, to select an appropriate treatment regimen, and to provide prognostic guidelines. Megavoltage irradiation to the retroperitoneal and ipsilateral pelvic node-bearing locations is the basis of treatment for patients with pure seminoma diagnosed by radical orchiectomy. Survival rates range from up to 100% for stage I to as low as 20% for stage III. Regional therapy is appropriate for management of nonseminomatous germinal malignancies. Prognosis depends somewhat on treatment, which consists of inguinal orchiectomy combined with either retroperitoneal lymphadenectomy or retroperitoneal radiation therapy alone, or with retroperitoneal lymphadenectomy plus either radiation therapy or chemotherapy.

Antineoplastic Agents↗
PubMed1979

Effects of preliminary normothermic flushing on hypothermic renal preservation.

Flushing of harvested kidneys with hypothermic perfusates is presumed to cause inappropriate circulation due to vasospasm. Effects of initial normothermic flushing prior to hypothermic flushing and cold preservation were tested in canine kidneys. Analysis of the perfusion characteristics revealed that a brief initial flushing with solutions at 37 degrees C. eliminates vasoconstriction and even facilitates subsequent hypothermic flushing. In amounts not exceeding 100 cc. it was not deleterious to transplant function. Larger volumes of normothermic flushing were proved to cause endothelial injury and resulted in poor transplant survival.

Animals↗
PubMed1979

In situ flushing of donor kidneys: its technique and rationale.

In situ flushing of kidneys through an isolated segment of aorta was done on mongrel dogs. The 500 cc cold perfusate at 3 to 4C (delivered in 6 minutes) effectively cooled the kidneys to about 15C. This simplified technique of in situ flushing, its usefulness and rationale are discussed.

Animals↗
PubMed1978

Magnesium: not essential for renal preservations by initial perfusion and hypothermic storage.

Experimental observations regarding the role of divalent magnesium ion in hypothermic renal preservation have presumed the inclusion of this substance in synthetic preservation media. Retrospective analysis of the validity and application of these experimental data and consideration of the problems related to precipitation of magnesium salts in "intracellular" perfusates has instigated investigation related to the necessity of including this ingredient in our previously described hyperosmolar intracellular electrolyte solutions. Omission of magnesium chloride from these perfusates has not adversely affected ultimate renal function in canine kidneys preserved for 2 and 3 days following perfusion and storage in these solutions. The absolute necessity of including magnesium in these solutions in order to effect successful renal preservation is challenged.

Animals↗
PubMed1977

Squamous metaplasia and invasive epidermoid carcinoma of bladder.

Invasive epidermoid carcinoma of the urinary bladder is described in a young woman with a long history of bladder infections and extensive squamous metaplasia without atypia. The literature on squamous metaplasia and leukoplakia progressing to epidermoid carcinoma of the chronic dysuria, bladder infections, and long histories of squamous metaplasia of the bladder should be followed up very closely. If epidermoid carcinoma of the bladder develops, they should undergo radical surgery.

Adult↗
PubMed1977

Complications of urinary undiversion.

Complications of urinary undiversion may be divided into those related to patient selection and those pertaining to the operation. A detailed understanding of the anatomic and physiologic alterations in the dynamics of urine transport is an essential prerequisite for the selection of suitable candidates. Two illustrative cases emphasize the necessity for complete evaluation of the upper and lower urinary tracts as well as meticulous attention to intraoperative detail.

Adolescent↗
PubMed1975

External velour dacron grafts in renal artery reconstruction.

Aortorenal interposition grafts were performed in dogs using a new external velour knitted Dacron graft. Encapsulation and endothelialization of these grafts occurs as early as two weeks postoperatively. Complete healing is seen by six weeks, and the cellular lining of these grafts appears to be continuous with, and histologically similar to, the endothelium of contiguous arteries. The healed nonthrombogenic characteristics of this graft material represents a considerable improvement over graft materials of conventional design.

Animals↗
PubMed1975

Pelvic lipomatosis: effect of diet.

Pelvic lipomatosis is a disease of dense infiltration of benign fatty tissue within the confines of the deep bony pelvis. A case is reported of an obese, hypertensive, thirty-nine-year-old black man with the typical clinical and radiographic features of pelvic lipomatosis. Prolonged fasting produced an extensive weight loss and profound resolution of his presenting symptoms, signs, and radiologic abnormalities. Subsequent regain of weight resulted in the reappearance of the disorder, confirming that pelvic lipomatosis may be a disease of accelerated and excessive fat deposition which can be reversed by dietary restriction. The literature pertaining to pelvic lipomatosis is reviewed in detail.

Adult↗
PubMed1975

Prostatic carcinoma producing syndrome of inappropriate secretion of antidiuretic hormone.

The syndrome of inappropriate secretion of antidiuretic hormone was recognized in a sixty-year-old man with a poorly differentiated metastatic adenocarcinoma of the prostate gland. Elevated levels of antidiuretic hormone were found in the patient's serum and in the prostatic tumor but not in the cerebrospinal fluid. The patient's clinical course is detailed, and the pathophysiology of this syndrome is discussed.

Adenocarcinoma↗
PubMed1975

Urologic complications of appendicitis.

Three patients with appendicitis were seen with bladder tumor, hematuria, and pelvic mass with ureteral obstruction, respectively. These cases represent a spectrum of difficult diagnostic problems and illustrate that appendiceal abscess involving the urinary tract may present as urologic disease. Thus, it is important to consider appendicitis in the differential diagnosis.

Adult↗
PubMed1975

Urethral adenocarcinoma (possibly originating in the glands of Littre).

Adenocarcinoma involving the bulbomenbranous urethra is a rare disease. This disease is describe in a 30-year-old man and the surgical management is detailed. The adenocarcinoma described seems to have arisen from the periurethral glands of littre. Despite the radical nature of the tumor excision, it was possible to spare the distal penis in order to achieve a more normal appearance of the external genitalia.

Adenocarcinoma↗