Biomedical subjects
Publications and source records attributed to S A Sadek.
Six cases of bilateral abductor palsy with stridor are presented. Following unilateral intralaryngeal arytenoidectomy, four had adequate airways and reasonable voices. Two required bilateral arytenoidectomy, one acquired an adequate airway at the expense of a weakened voice, and the other still requires a tracheostomy. There was only one minor complication. Decannulation and discharge from hospital were usually rapid.
An assay for estrogenic and antiestrogenic activity of seven selenoestrogens has been carried out in immature female rats. The estrogenic activity was compared to the in vitro binding affinity data. The study reveals that introduction of selenium substituents on C-16 or C-17 of the steroid nucleus produced a marked reduction in the estrogenic activity. The selenium analogues of ethynylestradiol produced the highest estrogenic activity. None of the compounds produced antiestrogenic activity.
Two 75Se-labeled aralkylamines, 2-(3,4-methylenedioxyphenylseleno)ethylamine hydrochloride (75Se-6) and 1-methylseleno-1-phenylethylmethylamine hydrochloride (75Se-9), were prepared with high specific activity applying two different chemical means starting from [75Se]selenious acid. Tissue distribution studies in rats show high uptake in the lungs with lung/blood ratios of 27/1 and 2.3/1 at 10 min for compound 75Se-9 and 75Se-6, respectively. High adrenal uptake and adrenal-to-blood ratio (15/1 at 2 h) of compound 75Se-9 were observed. This study indicates that aralkylamines can accommodate a Se group and still show high uptake by the organs that contain appreciable amount of dopaminergic receptors.
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A case of metastatic carcinoma of the external auditory meatus secondary to a primary adenocarcinoma of the rectum is presented, together with histological evidence of the association of these tumours.
Selenium-75 labeled selenonium analogues of dopamine, [2-(3,4-dimethoxyphenyl)ethyl]dimethylselenonium iodide (4) and its dihydroxy analogue (7), were prepared by reducing [75Se]selenious acid with sodium borohydride at pH 6.0 and reacting the NaSeH produced with 1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane. Tissue distribution studies in rats given the 75Se-labeled selenonium agents intravenously demonstrated high initial heart uptake (2.38% dose/g at 5 min). Prolonged adrenal retention (t1/2 = 10 h) and high adrenal to blood ratio of compound 4 (21/1 at 4 h after injection) were observed. The high uptake and adrenal to blood ratio suggest the potential use of compound 4 as a radiopharmaceutical for the adrenal gland.
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The opening pressure and flow rates through the sphincter of Oddi using the patient's own bile to prime the system were measured daily in 17 patients after cholecystectomy and exploration of the common bile duct. The sequential changes in these parameters were correlated with preoperative serum bilirubin, bile bacteriology, biliary lipid composition, and bile viscosity. The opening pressure fell from an initial value of 17.2 +/- 1.9 to 9.1 +/- 0.9 cm bile (p less than 0.01) on the seventh postoperative day, indicating a self-limiting hold-up following stone extraction. The low opening pressure after the fifth to sixth day is well below the maximal hepatic secretory pressure and suggests that the bile flow into the duodenum may be continuous after cholecystectomy. The flow rate through the sphincter measured at a fixed pressure head of 30 cm of bile increased from 23.9 +/- 3.9 to 40.0 +/- 6.1 ml during the same period (p less than 0.01). Presumably, the latter represents the maximal flow rate of bile through the sphincter of Oddi under physiological conditions. These changes in flow could not be explained by alterations in the bile viscosity during the study period. The increase in flow rate was significant only in the nonjaundiced group and correlated positively with the phospholipid concentration in the bile. There were no significant differences in opening pressure, flow rates, and biliary lipid concentrations between patients with sterile bile and those with positive bile cultures.
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