Biomedical subjects

S A Schwan

Publications and source records attributed to S A Schwan.

3 recordsLinked to original sources

PubMed1992

Audiometric test criteria in the detection of cisplatin ototoxicity.

Audiometric criteria establishing the ototoxic effects of cisplatin (CDDP) vary widely in the literature. Normal test-retest variability in audiometric thresholds resulting from serial audiometry is likely a confounding variable in the over-reporting of ototoxic effects. This study investigated the variability of serial audiometry for a group of 21 head and neck cancer patients receiving no known ototoxic drugs in an effort to establish guidelines for determining reasonable audiometric criteria for CDDP therapy. Comparison of this group to a similar group of 31 patients receiving high dose (100+ mg/m2) bolus administration of CDDP suggests that audiometric shift criteria developed from Receiver Operating Characteristic analysis and employing multiple frequency averaging above 1000 Hz may lead to more universally accepted audiometric criteria for ototoxicity, which should in turn lead to more reliable reports of disease incidence.

Acoustic Stimulation↗

PubMed1991

Pseudohypacusis.

This article provides the basis for the techniques and interpretation of audiologic tests useful in evaluation of the patient with pseudohypacusis. Differences between the childhood and adult forms of the problem are discussed. The indications for currently popular conventional and special tests are presented. These include both behavioral and electrophysiologic measures for assessing auditory function.

Audiometry↗

PubMed1989

Evaluation of the monothermal caloric test.

In 1970, Torok reported that patients with labyrinthine disease showed vestibular recruitment and that patients with retrolabyrinthine disease showed vestibular decruitment on the monothermal caloric test. Other investigators have failed to confirm these findings; however, their studies did not precisely replicate Torok's test procedure. Following Torok's procedure exactly, the monothermal caloric test was administered to normal individuals and to patients with well-documented vestibular lesions. Nine of ten normal persons showed normal responses and one person showed borderline decruitment. Six of eight patients who had lesions of the vestibular nerve or central vestibular pathways showed decruitment. Two patients with active Meniere's disease showed recruitment and one showed asymmetry. Two patients with Meniere's disease who had undergone endolymphatic sac operations showed normal responses. These findings support Torok's claim that the monothermal caloric test discriminates between labyrinthine and retrolabyrinthine vestibular pathology.

Adult↗