Biomedical subjects
Publications and source records attributed to S A Seleznev.
The authors consider that the application of Levamisol in the treatment of patients decreases the amount of complications if the degree of shock was not great. In greater degree of shock Levamisole failed to exert a favorable effect.
A comparative evaluation of the antishock effectiveness of the ablation of intracranial hematomas by means of various surgical accesses was made. The method of mathematical analysis based on the principle of "moving averages was used. It was shown that the potential antishock effectiveness of the ablation of intracranial hematomas was maximum after using cutter openings and minimum after using the osteoplastic access.
In contrast to the reported data evidencing early impairment of the liver mitochondrial function in the Wiggers model of hemorrhagic shock at the arterial blood pressure 30-40 mm Hg, lasting not over 6 h, a group of hemorrhage-resistant rats was discovered. In these rats, the lifetime was about 20 h, with the blood pressure being the same as indicated above. Rectal temperature decreased to 24-25 degrees C during shock. No substantial disorders were recorded in oxidative phosphorylation and ATPase activity of the mitochondria isolated from the liver in the irreversible stage of shock (70% blood return) or in the terminal state of animals. It is assumed that hypothermia plays the protective role. The conclusion is made that the damage to the mitochondria is not indispensable factor of the development of irreversible shock.
The observations were performed in 83 patients. It was shown that liquid crystal thermography allowed timely diagnosis of acute mastitis, its form, spread of the process, appearance of a recurrent destructive process in the gland.
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A relative stability of the adenylate nucleotide system redox of liver and kidney cells was recorded in rats during the first day after acute hemorrhage (2.5% of body weight) in spite of a severe course of the posthemorrhagic period. Energy metabolism was examined in the state of the decompensation of circulation at a blood pressure of 35-45 mm Hg that progressively fell down after a short-term stabilization at the level of 40-60 mm Hg. Comparison of the results obtained with the reported data warrant conclusion that the magnitude of the critical arterial blood pressure at which the test parameters change lies between 40 and 50mm Hg and can vary in relation to a number of the conditions.
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Changes in microcirculation and oxygen pressure in the liver and kidneys were studied in experiments on 42 rats in the course of experimental traumatic shock elicited by Cannon's methoicroscope with a microphoto adapter MFN-12. Oxygen pressure was recorded with the aid of active open hemispheric platinum electrodes with diameters of 150-200 mum. With advencing shock, considerable disturbances of microcirculation and PO2 occurred in hepatic and renal tissues. By the end of the torpid phase of the shock, the PO2 in the liver sank to 1/2.4, and in the kidneys, to less than 1/4 of the respective initial values. The changes in microcirculation were of an ischaemic, vasospastic type in the kidneys, and of a mosaic pattern in the liver: ischaemic segments alternated with areas fully supplied with blood. A severe and rapid course of shock was accompanied by more marked disturbances of PO2 and circulation in hepatic and renal terminal vessels.
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