Biomedical subjects

S A Shalaby

Publications and source records attributed to S A Shalaby.

2 recordsLinked to original sources

PubMed1991

Hydantoin immunosuppression clinical study.

A study was conducted on 51 epileptic patients divided into two groups. Group 1: 20 patients without anticonvulsant treatment for at least two years, and group II: 31 patients receiving phenytoin in a dose of 300 mg/24 hr for at least 4 months. A group of normal and blood donor subjects were used as control. The serum concentrations of IgA and IgM were significantly decreased in the phenytoin treated patients in comparison with control. Non-treated epileptics showed a significant decrease of IgA level in comparison with control. It was suggested that phenytoin treatment suppresses the normal function of the humoral immune response and that epilepsy may be a contributing factor.

Adolescent↗

PubMed1989

Effect of lead nitrate administration on liver and kidney structure in rats.

A study was conducted on male albino rats ranging in weight between 150-180 g. The animals were given a single and repeated intravenous injections of lead nitrate (100 mu mol/kg body weight) once every 10 days for one, two, three and four injections respectively. Histopathological examination revealed that induction of hepatic and renal cellular proliferation without cellular necrosis occurred with single and repeated administration. No biochemical alterations in liver function tests and serum creatinine were detected throughout the whole period of study. These changes are suggested to be an adaptive response rather than a toxic effect.

Animals↗