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Biomedical subjects

S A Sharova

Publications and source records attributed to S A Sharova.

11 recordsLinked to original sources
PubMed2005

Evaluation of mutagenic activity of dioxazid by the polyorgan micronuclear method in experiments on rats.

The mutagenic effect of antituberculous drug dioxazid was studied on rats receiving this preparation in a dose of 25 mg/kg (in conversion to dioxidine) via inhalation route for 3 months. The percentage of cells with micronuclei and the content of polychromatophilic erythrocytes among all bone marrow erythrocytes and percentage of cells with micronuclei, protrusions, and binucleated cells in the lungs and urinary bladder were evaluated. Dioxazid caused no changes in organs, except the increase in the percentage of binucleated cells in bladder epithelium, which attests to minor cytotoxic effect of the drug for this organ.

Administration, Inhalation↗
PubMedDate not supplied

[Toxicological study of an antiviral drug, bonaphthon].

The toxicity of bonaphthon was studied on laboratory animals of different species (mice, rats, guinea pigs, dogs) with its single and repeated (daily, for a space of 4 months) administration. It has been found that bonaphthon, with its single and repeated administration in doses much higher (by 16 to 32 times) than the ones recommended for human beings, is well tolerated not only by sexually mature, but also by immature animals (rats). Bonaphthon does not affect adversely the dynamic changes in the weight of the animals, nor does it have any effect on the diuresis, functional state of the gastro-intestinal tract and the cardiac activity. On its administration in toxic doses exceeding by 60 and more timesthe ones recommened for human beings the drug provokes flabbiness, bradycardia, a fall of arterial pressure and causes changes in the activity of nonspecific enzymatic systems of the liver. Among the test animals most sensitive to bonaphthon are mice.

Animals↗
PubMedDate not supplied

[Toxicological characteristics of the Soviet antidepressant pyrazidol].

It has been demonstrated in different species of experimental animals (mice, rats, cats, dogs) that the Soviet drug pyrazidol is a little toxic drug. Prolonged repeated administration of pyrazidol does not exert any damaging action on the vitally important organs and systems of the body. Pyrazidol is less toxic than imipramine.

Animals↗
PubMedDate not supplied

[Tolerance for nonsteroidal anti-inflammatory agents by experimental animals during pregnancy].

The authors studied the tolerance of three nonsteroidal anti-inflammatory drugs, voltaren, indomethacin and ibuprofen by rats at different times of pregnancy and compared voltaren tolerance by pregnant and nonpregnant females. It was shown that as compared to nonpregnant animals, pregnant animals tolerated voltaren more poorly. The tolerance of both voltaren and indomethacin was particularly poor in the last trimester of pregnancy. The enhancement of the drug toxicity during pregnancy because of the changes in body function is discussed.

Animals↗
PubMedDate not supplied

[The effect produced by pyrazidol on the gastrointestinal tract].

In experiments with animals pyrasidol, a new Soviet-made tetracyclic antidepressant, lowers the tone and peristalsis of the intestines, reduces cholic acid secretion in the liver and basal gastric secretion to a lesser degree than this does imipramine.

Animals↗
PubMedDate not supplied

[Tolerance for prospidin ointment].

The local and resorption action of 50% prospidin ointment administered at doses up to 100 mg/kg for a long time was studied in rabbit experiments. Prospidin ointment was established to exert no resorption action in doses tested. At the site of the ointment application there occur skin necrotic changes. Complete regeneration of the epithelium with hair recovery is recorded 2 months after the drug is discontinued.

Animals↗