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Biomedical subjects

S A Velichko

Publications and source records attributed to S A Velichko.

At least 19 recordsLinked to original sources
PubMed2003

[Multi-media computer-based chart: modern tool of clinical record keeping].

AIM: To design the program of computer multimedia case history (MCH) for collection, storage and analysis of information about the patient including diagnostic images; to test MCH for application in telemedical consulting and control over valid conduction of the treatment protocol. MATERIAL AND METHODS: Brief representation of information is reached by integrated multilevel placement of the data on common time axis. Dynamics of the selected parameters is represented as normalized diagrams in the same system axes. Electron tables are filled either by hand or import of the data from individual electron file of all the information about the patient. Diagnostic images and conclusions are obtained from local computer bases of the diagnostic units. Inexpensive commonly used computers allows one to input digital micro- and macrophotos, x-ray images, etc. Monitor information is available from the universal computer net directly from the monitors Geolink-M. RESULTS: MCH was tested in the Hematological Research Center of RAMS. In cooperation with Bryansk diagnostic center N 1 telemedical consulting and some data bases were perfected. The MCH system joints routine activity of the clinic without any problems raising quality of the patients management, facilitating the access to therapeutic and diagnostic information and its analysis. On-line breaking the limits of the controlled parameters and protocols is detected automatically. These events are emphasized by "blocking questions" which must be worked out by the user. The information on the patient can be fully stored on CD-ROM in line with the MCH program providing organization of the data. CONCLUSION: The system is introduced which collects medical information from various sourses and builds up comprehensive representation of the data on the same time axis. The system provides control over implimintation of the protocols of the patients' management, gives a convenient access to medical information, ensures its reliable storage and availability in case of the patients transfer to other medical institutions, facilitates analysis of clinical cases, conduction of medical consulting.

Computer Communication Networks↗
PubMed2002

[Investigation of mutations of BRCA1 and BRCA2 genes in 52 breast cancer patients].

The proportion of BRCA1/2 genes varies widely among populations. We investigated 52 cases of breast cancer: 24 cases of familial breast cancer, 22--early-onset (till 40 years) and 6--bilateral cancer. The frequency of carriers of mutations among familial cancer cases was 16%, among cases of disease till 40 years--9%. 538insC BRCA1 was the most common genetic mutation among hereditary cases of breast cancer.

Adult↗
PubMed2000

[Role of transthoracic fine-needle aspiration in the diagnosis of peripheral lung cancer].

The efficacy of transthoracic fine-needle aspiration guided by roentgenotelevision (86 cases) and computed tomography (106 cases) for peripheral lung cancer was studied. Special needles Nos. 18-20G (dia. 1-1.2 mm) and Nos. 22-25G (dia. 0.5-0.7 mm) were used depending on size and site of tumor. Roentgenotelevision imaging proved more informative for small-size tumors (less than 2 cm). Computed tomography offered more advantage in imaging medium- and large-size tumors because it allowed to avoid repeated aspiration and, therefore, reduce the risk of complications.

Adenocarcinoma↗
PubMed2000

[Causes of exploratory thoracotomies in lung cancer].

Exploratory thoracotomies were studied in 80 patients with inoperable lung cancer. The X-ray and computed tomography findings were analyzed retrospectively. The main causes of inoperability of lung cancer were determined. The authors consider that CT findings are of greater importance as compared with the routine X-ray examination and linear tomography for determining the lung cancer operability.

Adenocarcinoma↗
PubMed1999

Quantification of breast cancer blood flow in absolute units using Gjedde-Rutland-Patlak analysis of 99mTc-MIBI uptake.

BACKGROUND: Scintimammography with 99mTc-MIBI has been proven as efficient technique of diagnosis of breast cancer. Nevertheless, quantification of breast carcinoma blood flow (BCBF) in absolute units is not yet developed. To compensate this, we analysed kinetics of 99mTc-MIBI uptake in breast cancer using Gjedde-Rutland-Patlak (GRP) approach. METHODS: If BC is radioactivity in breast cancer quantified by dynamic scintigraphy, C(h)-blood concentration of 99mTc-MIBI and K-transport constant, then, assuming 99mTc-MIBI uptake to breast carcinoma unidirectional for early minutes after injection and subjected to equation d(BC)/dt = K; C(h), classic GRP plot can be obtained from this by integration as BC/C(h)=K x (integral of C(h)(dt))/C(h) + V0 and placing [(integral of C(h)(dt))/C(h)] as X, and (A/Ch) as Y. The K can be then obtained as slope. K is breast cancer clearance equal to product (retention fraction); (blood flow) : K = E; BCBF. K can be calculated from A(t) and Ch(t) as asymptote of 99mTc-MIBI retention function h(t) = F-1[F[A(t)]/F[Ch(t)]], where F depicts Fourier transforms. The BCBF can be then obtained as ratio K/E. We employed the technique in 33 patients with breast carcinoma of stages T(1-3)N(0-3)M(0-1) injecting 99mTc-MIBI (370-510 MBq) as i.v. bolus. In 12 scintigraphy with 99mTc-MAA (370 MBq) injected via catheter intraaortically was performed as validation study. RESULTS: E values were essentially uniform over the population with overall mean 0.58 sd 0.06. Blood clearance curves did not differ between various stages also and were subjected to biexponential approximation. K was in all cases obtained from the slope of initial 3 min part of GRP plot, strongly linear (r > 0.95, p < 0.001) in all cases. 99mTc-MAA validation study revealed significant correlation with 99mTc-MIBI blood flow values (r = 0.94, p < 0.01). The BCBF(as ml/min/100 cm3) was in T1 12.85 sd. 4.76, in T2 15.87 sd. 1.78, in T3 17.35 sd. 2.45, and in T4 23.07 sd. 2.21, expressing tendency to increase with stage. Higher BCBF was significantly associated with metastatic spread and in patients with BCBF over 17 ml/min/100 cm3 distant mets were revealed in all cases. CONCLUSION: Hence, analysis of early kinetics of 99mTc-MIBI in breast carcinoma provides correct estimates of blood flow in the neoplasm and can be applied in clinical studies and for calculation of cytostatic delivery to BC.

Journal Article↗
PubMed1992

[The dynamics of the hormonal and tumor marker levels in response to adrenaline administration in lung cancer patients].

CIA, ferritin, ACTH, cortisol, TTH, T3, T4, insulin, CT and PTH levels were assayed radioimmunologically in the blood serum of 227 patients with lung cancer, stages I-IV, 134 cases of chronic nonspecific diseases of the lung, 28 patients with benign tumors of the lung and 30 healthy subjects. Adrenaline tests were carried out in 160 of them. Similar shifts were observed in hormone profile in both cancer and non-cancer patients. The predictive value of the hormone tests for stage I-II cancer appeared higher than in those for CIA and ferritin. However, the diagnostic value of a single test of marker proved insufficient for its practical use. Adrenaline tests identify fine disturbances in endocrine regulation and considerably raise the predictive value of such indicators as ACTH, insulin, TTH, T3, T4 and calcitonin. To assure high effectiveness of the use of basic radioimmunological data, a combination of indexes should be prepared for each case, and it should include, apart from basic levels of markers, their post-test values and indexes of reactivity.

Adenocarcinoma↗
PubMed1992

[The potentials of computed tomography in assessing the spread of lung cancer].

The paper presents the results of a complex examination of 198 cases of lung cancer, using computed tomography, which provided additional data in 52.3% of cases. These data were used to assess the tumor spreading to the mediastinum, pleura and thoracic wall. The computed tomography-related features of lymphatic nodes of the mediastinum, both normal and metastatically involved, are discussed.

Adenocarcinoma↗
PubMed1990

[Long-term radiation injuries following neutron therapy].

The paper is concerned with the data on late radiation injuries of normal tissues and critical organs in a group of 35 patients after fast neutron therapy in a period of 12 mos.-3.5 yrs. The value of radiation exposure of critical organs and tissues was considered for patients with head and neck tumors in relation to methods of fast neutron therapy and photon radiation with 60Co after a radical program.

Adult↗
PubMed1989

[Characteristics of hormone homeostasis in men who have been smoking for a long time].

Radioimmunoassay of 12 hormones, carcinoembryonic antigen and ferritin in blood serum was carried out in 140 subjects at high risk for lung cancer. The study group included males aged more than 50 with a questionnaire-based record of smoking for more than 20 years. 140 patients with stage I-III lung tumors and 40 healthy subjects were in control. The profile and trends of hormonal shifts in those at risk and stage I-III lung cancer patients proved identical but were significantly different from the same parameters in healthy subjects. In the group at risk, endocrine disorders were more pronounced than the rise in tumor marker levels.

Aged↗
PubMed1988

[Main indicators of hormonal status in lung diseases].

A radioimmunoassay was used in vitro in the blood serum of 156 lung cancer patients, 21 patients with benign pulmonary tumors and 100 patients with chronic nonspecific pulmonary diseases to study the levels of 9 hormones reflecting function of the major links of endocrine regulation. The most important feature of pulmonary tumor growth was the activation of the hypophyseal-adrenal system. Endocrine shifts in lung cancer and in chronic nonspecific pulmonary diseases were similar in nature. Of the entire spectrum of hormones the importance of ACTH, cortisol, calcitonin and parathyroid hormone was emphasized in differential diagnosis of lung cancer.

Adrenocorticotropic Hormone↗