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S Aaron

Publications and source records attributed to S Aaron.

23 records · Page 2Linked to original sources
PubMed1985

Neutropenia occurring during the course of chrysotherapy: a review of 25 cases.

The records of 25 patients who developed neutropenia (granulocyte count less than or equal to 2500 mm3) while receiving intramuscular gold sodium aurothiomalate (GSTM) were reviewed. According to commonly used clinical criteria, 3 patients developed Felty's syndrome, 8 gold myelotoxicity, and 14 mild, chronic benign granulocytopenia. Myelotoxicity occurred exclusively during the initial course of therapy (less than or equal to 1 g GSTM). Twelve of the patients with chronic granulocytopenia continue to receive gold without other signs of serious toxicity. We conclude that Felty's syndrome can develop during gold administration, and that many patients may continue safely to receive gold despite neutropenia.

Agranulocytosis↗
PubMed1975

Selective ligation of the hepatic artery for trauma of the liver.

Selective ligation of sundry hepatic arteries in patients with hepatic trauma obviated death from hepatic bleeding in 59 of 60 patients treated with this method of hemostasis. Hepatic insufficiency did not occur in survivors. Reconstitution of intrahepatic arterial flow is rapidly accomplished by collateral arteries. When the source of hemorrhage is perihepatic, that is, hepatic veins and retrohepatic vena cava, hepatic artery ligation is ineffective. Two patients died from this kind of hemorrhage.

Adolescent↗
PubMedDate not supplied

Synovial cell secretion of IL-2 in vitro, a limiting dilution analysis.

Limiting dilution analysis (LDA) was used to analyze the defect of production of IL-2 by synovial fluid cells in rheumatoid arthritis (RA). LDA is a relatively simple means of separating T-cell function from the potential effects of accessory-cells, suppressor factors and adsorption. The number of precursor cells for interleukin-2 (IL-2) secretion was determined among peripheral blood cells (PBL) from healthy control individuals, and in PBL and synovial fluid (SF) mononuclear cells from patients with rheumatoid arthritis (RA). Although the frequency of such cells in the PBL of the controls and RA patients was similar, that of the SF was significantly lower (about one sixth). This difference could not be accounted for by an inability of the SF cells to proliferate in culture, by the presence of suppressor cells, by absorption of IL-2, or by a relative lack of accessory-cell function in the SF fraction. Culturing synovial cells without stimulant for three days resulted in a two- to three-fold increase in the apparent frequency of secreting cells, but the same proportional increase followed similar manipulation of peripheral blood cells. Pre-incubation of normal lymphocytes in RA synovial fluid did not result in suppression of their ability to secrete IL-2. We conclude that the poor secretion of IL-2 after mitogen stimulation of SF cells is an intrinsic property of the T-cell, and not due to the presence of other factors. There was no evidence that this defect was selectively reversible by "resting" the cells prior to culture.

Adult↗
PubMedDate not supplied

The effect of in vivo and in vitro methotrexate on lymphocyte proliferation as measured by the uptake of tritiated thymidine and tritiated guanosine.

In several studies methotrexate therapy of patients with rheumatoid arthritis has not been found to depress the lymphocyte response to mitogens measured by the uptake of tritiated thymidine. We have postulated two effects of methotrexate on stimulated lymphocytes in vitro: a decrease in cell proliferation, but also a relative increase in thymidine uptake reflecting a specific decrease in the intracellular thymidine pool. The increased incorporation of tritiated guanosine by mitogen-stimulated lymphocytes was found to be markedly depressed by methotrexate (1 x 10(-7) M) in vitro whereas the incorporation of thymidine was often unchanged. Thymidine uptake of lymphocytes may not be an appropriate measure of stimulation in the presence of methotrexate.

Guanosine↗