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Biomedical subjects

S Abram

Publications and source records attributed to S Abram.

3 recordsLinked to original sources

Accuracy in equianalgesic dosing. conversion dilemmas.

The clinical benefit and increased application of opioid rotation has focused attention on efficacy differences between opioids and their respective equianalgesic dose ratios. Understanding the differences between the opioids is critical to understanding their equianalgesic dose ratios and for adjusting therapy following rotation to a new analgesic. The purpose of this article is to describe controversies regarding the relative potencies of these agents as presented in current equianalgesic charts and to provide pharmacologic information to assist the clinician with opioid rotation.

Analgesics, Opioid↗

Technetium mixed-ligand complexes containing bidentate phosphines and monodentate thiol ligands. Preparation, in vitro data and detection of a certain heart affinity.

TcO-4 is reduced by a mixture of phosphine and thiol ligands to yield cationic complexes in which both ligands are coordinated. Polar and lipophilic properties of the products can easily be controlled by variation of either of the ligands. The yields are always high. Potential heart affinity of the compounds was screened by means of the isolated perfused rat heart. Some of the complexes show significant heart uptake and good retention in the myocardial tissue.

Animals↗