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Biomedical subjects

S Akyar

Publications and source records attributed to S Akyar.

8 recordsLinked to original sources

Diametral measurements of the upper spinal cord for stereotactic pain procedures: experimental and clinical study.

BACKGROUND: Stereotactic percutaneous pain procedures, percutaneous cordotomy, trigeminal tractotomy, and extralemniscal myelotomy are routinely performed with computed tomography (CT) guidance. This new imaging technique enables one to measure the spinal cord diameters for each patient uniquely. Significant differences have been recognized between the measurements obtained with CT and the reference values given for such procedures. METHODS: To confirm the reliability of CT measurements, two experimental models were used. In the first stage, an artificial neck and spinal cord model was set up and diameters of the spinal cord were remeasured with CT. In the second stage, spinal cord diameters of the upper cervical region on 10 mongrel dogs were initially taken with CT, then standard laminectomy was performed and diameters of the same region were measured under the operating microscope. RESULTS: The experimental studies confirmed that CT measurements of the upper cervical cord are reliable. In clinical application, diametral measurements of the spinal cord at occiput C-1 level were carried out in 30 patients who underwent percutaneous trigeminal tractotomy and extralemniscal myelotomy. The anteroposterior diameter at this level was measured at 7.0-12.8 mm and the transverse diameter ranges between 9.3-14 mm. At the level of C-1-C-2, these measurements were performed over 63 patients who experienced percutaneous cordotomy. In this group the anteroposterior (A-P) diameter was measured as 7.0-11.4 mm, and the transverse diameter as 9.0-14.0 mm. CONCLUSIONS: Our clinical experiences and the results of the experimental measurements demonstrate that CT imaging gives accurate diametral values that would favorably influence the surgical procedures, and thus, with CT imaging it is possible to perform main stereotactic destructive pain procedures safely, effectively and selectively.

Animals

Localized non-Hodgkin's lymphoma of the adrenal and thyroid glands.

A case of immunoblastic lymphoma, involving only the thyroid and the adrenal glands, is presented. The patient had clinical symptoms and findings of Addison's disease, and computed tomography (CT) demonstrated bilateral adrenal tumoral enlargement. He also had euthyroid diffuse multinodular goiter. The diagnosis of the patient was based on the cytological examination of the aspiration materials from both endocrine glands. The patient received "m-BNCOD" chemotherapy regimen and replacement therapy for Addison's disease. At the end of three courses, a partial response was obtained.

Addison Disease

C.T.-guided pain procedures.

C.T.-guided stereotactic destructive pain procedures; percutaneous cordotomy, trigeminal tractotomy-nucleotomy and extralemniscal myelotomy are presented. All procedures were applied in 32 cases without any mispuncture or complication. Advantages of C.T. guidance are direct visualization of target electrode relations, measurements of spinal cord diameters at the lesion site, and demonstration of spinal cord displacement during the procedure.

Cordotomy

CT-guided percutaneous cordotomy.

Percutaneous cordotomy is a commonly applied and effective procedure among the ablative pain surgeries. As plain X-ray does not permit visualization of the target relative to the electrode the chances of obtaining good results are decreased and the risk of complications are increased. The use of CT has been found to be useful in cordotomy. The procedure is performed under CT control on the patients who have previously been given 5 ml iohexol into the subarachnoid space. The needle electrode is manipulated by free hand technique. It is possible to measure the diameter of the spinal cord and to detect cord dislocation in the spinal canal. When the electrode system is introduced it is possible to visualize the tip of the electrode which is pushing or puncturing the spinal cord. As the procedure directly visualizes the relation of the electrode to the target it is possible to place the electrode in the lateral spinothalamic tract. Another advantage of the procedure is to enable us to visualize haematomas or other changes that may result from the cordotomy. The application of the technique and clinical results will be presented.

Electrocoagulation

CT-guided trigeminal tractotomy.

Trigeminal tractotomy is an effective procedure in denervating pain areas of 5th, 7th, 9th and 10th nerves. The classical imaging technique is the x-ray method which visualizes the target electrode relation indirectly. The method of CT-guided trigeminal tractotomy demonstrates the target electrode relation directly.

Humans

Intrarenal lipoma: report of a case.

We recently had the opportunity to study a case of renal lipoma. Pure intrarenal lipomas are very infrequent among all of the renal tumors and computed tomography is the only means of showing the fatty nature of such masses with its contrast discrimination property.

Female

Asymptomatic-nonfunctional adrenal masses detected by CT.

We identified as an incidental finding "silent adrenal tumors" in 12 patients undergoing abdominal computed tomography (CT) scanning for unrelated problems. Until recently, adrenal masses came to clinical attention either from local symptoms due to massive enlargement or from manifestations of excess hormone production. With CT, small adrenal glands and neoplasms could be also visualized and diagnosed at an earlier preclinical stage. Patients with asymptomatic adrenal masses detected by CT scan must be investigated for the possibility of metastasis from another primary site, secondly screened for hormone production and should be followed-up for malignant degeneration. The investigation did not show any sound criteria for the diagnosis of malignancy except the follow-up of the masses with serial CT scans in short intervals.

Adrenal Gland Neoplasms