The value of biochemical estimations on amniotic fluid in management of the high-risk pregnancy.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to S Aladjem.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The development of a technique allowing prolonged culture in vitro of normal term human trophoblast facilitates examining what effects, if any, drugs commonly used in pregnancy may have on placental tissue. Dosages compatible with therapeutic blood levels of magnesium sulphate, methyldopa, hydralazine and phenobarbitone were tested individually in vitro on monolayer cultures of normal term trophoblast. Hydralazine and magnesium sulphate additions resulted in a 100 per cent loss of viability of trophoblast cells. Phenobarbitone caused an 8 per cent decrease in cell viability, while methyldopa caused only a 2 per cent decrease in cell viability.