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Biomedical subjects

S Alberico

Publications and source records attributed to S Alberico.

34 records · Page 2Linked to original sources
PubMed1989

Flow cytometric analysis of DNA content in cervical lesions.

Flow cytometry is used to screen gynaecologic specimens for Cervical Intraepithelial Neoplasia (CIN) and its precancerous lesions, possibly associated with human papilloma virus (HPV), in order to investigate the role of aneuploidy as a biological marker in HPV and CIN lesions. A total of 299 cervical samples was collected by scraping and the cellular DNA content was measured using the propidium iodide staining procedure. Two groups of patients were studied; a group of 142 negative controls for cytology and groups of patients assigned to mild, moderate or severe dysplasia, carcinoma in situ diagnosed by histologic classification according to the Papanicolaou staining technique. Pathological samples showing an alteration of the DNA index or perturbation of the cellular phase S compartment ranged from 6.4% to 41.9%. Our results confirm those obtained by other authors and suggest the hypothesis that aneuploidy is present with permanence of viral DNA in early stages of carcinogenesis, which can be used as a marker in the transition from benign to malignant cells. This work is of potential interest for the possible follow-up of patients having condyloma and could aid the early diagnosis of cervical carcinoma.

Aneuploidy↗
PubMed1989

[Infection of Chlamydia trachomatis and dysplasia lesions of the cervix uteri (CIN)].

With the aim of evaluating the correlation between dysplastic lesions of the uterine cervix associated or not with condylomatosis and Chlamydia T. infection, we carried out a serological study of anti-Chlamydia species-specific antibodies and a direct and/or a cultural investigation on a sample of 320 women who performed a Pap-test. The serological examination showed positivity (titer greater than or equal to 1:32) in 49 control subjects (with negative cytology) (23.7%); in 27 cases (43.5%) with actual diagnosis of condylomatosis/CIN associated or not with condylomatosis and in 28 cases (54.9%) with previous diagnosis of condylomatosis/CIN associated or not with condylomatosis. The cultural investigation did not show any significant difference among the groups above mentioned. Finally, the frequency of positive cases for anti-Chlamydia antibodies was estimated for each grade of actual or previous CIN: a greater frequency of positivity was noted in cases with CIN 3 (75%).

Adult↗
PubMed1989

[Endometrial hyperplasia in the province of Trieste].

1103 cases of endometrial hyperplasia were diagnosed between January 1, 1978 and December 31, 1987 at the Department of Anatomy and Pathological Histology of the University of Trieste. Of these, 58% were cases of cystic glandular hyperplasia, 38% of adenomatous hyperplasia and 4% of atypical hyperplasia. Subdividing the period examined into two five-year periods, it was found that the rate of incidence of endometrial hyperplasias was more than doubled, this increase having been caused above all by cases of cystic hyperplasia. Distribution by age classes of subjects suffering from different hyperplastic forms suggests that cystic glandular hyperplasia is not a precursor of the adenomatous form, whereas the latter and atypical hyperplasia might constitute a continuous spectrum of potentially precancerous lesions.

Adolescent↗
PubMed1989

A clinical and epidemiological study of 245 postmenopausal metrorrhagia patients.

The authors report the incidence of endometrial adenocarcinoma and atypical hyperplasia in 245 women who had undergone uterine curettage for post-menopausal bleeding. In 4 cases a stenosis of the cervix precluded the curettage. Of the remaining 241 patients, 71.3% had negative histology; in 24.4% histology was compatible with adenocarcinoma or atypical endometrial hyperplasia; in a third group of 10 patients a different type of gynecological neoplasia was diagnosed. Obese, nulliparous women were more significantly affected by endometrial adenocarcinoma. The highest incidence was noted among women over 60 years of age. The authors describe some epidemiological and clinical characteristics of the population under study.

Adenocarcinoma↗
PubMed1989

Correlation between cervical intraepithelial neoplasia and invasive cervical carcinoma on the basis of their frequency in the Province of Trieste (1977-1986).

The Authors report the results of a study on the diffusion of CIN and of invasive carcinoma of the portio in the Trieste population over the 1977-1986 decade. In order to achieve this aim all the bioptical specimens analyzed in the Institute of Pathological Anatomy and Histology of Trieste University were reviewed. Over this period 313 cases of CIN 1-2, 314 cases of CIN 3 and 289 of invasive carcinoma were diagnosed. The average age for CIN 1-2 lesions was 33.5 (range 17-78), for CIN 3 39.9 (range 18-81) and for invasive carcinoma 58.6 (range 26-89). The distribution by age group was markedly different in the three types of lesion dealt with, showing a substantial presence of preinvasive lesions under the age of 50. During the period considered a significant decrease in the incidence of invasive carcinoma was not recorded, in contrast with other reports. This datum may be explained by the fact that the number of women undergoing cyto-oncological screening has not increased over the last decade.

Adolescent↗
PubMed1989

Cervical intraepithelial neoplasia with conization: early complications and follow-up.

The authors made a review of the last 100 cases who underwent a conization of the cervix during the period 1980-1986. Cyto-histological evaluation was compatible in 78% of the cases with a cervical intraepithelial neoplasia of third degree and in 22% with a CIN of first and second degree. Early post-operative complications consisted of a hemorrhage in 3% of the cases, easily stopped with a vaginal packing. In 2% of the cases a risuture under general anaesthesia was required. In 1 case the stitches loosened and in another a urinary infection was present. Twenty-six patients underwent total hysterectomy after conization for different indications; only one patient had a relapse after six months as there was a moderate dysplasia localized in the vaginal vault. During the follow-up, 14 patient became pregnant. Among these, 5 underwent legal termination during the first trimester and 9 delivered at term without any complication. During these follow-up of 7 years in the older cases and 6 months in the more recent ones, 6 cases displayed a persistence of the disease after 3 months, (CIN of variable degree) and 2 cases relapsed at the second colpocytological control. These patients, according to the age and the presence of clinical indications, underwent total hysterectomy or diathermic coagulation with resolution of the disease. A relapsing invasive tumor was never observed.)

Adult↗
PubMed1988

Frequency of cervico-vaginal infections (Trichomonas vaginalis; Chlamydia trachomatis -CHL-; herpes simplex virus -HSV-; human papilloma virus -HPV-) in cervical intraepithelial neoplasia.

The Authors have carried out a cyto-hystologic study on 533 cervical intraepithelial neoplasias (CIN) devoted to identifying the association frequency between cervical dysplastic lesions and cervico-vaginal infections caused by Trichomonas vaginalis, Chlamydia Trachomatis, Herpes Simplex virus and Human Papilloma virus. HPV lesions have revealed the pathology found more frequently in CIN lesions (33.2%) compared to 0.19% in the normal population, while the other infections have not shown significant differences between dysplastic lesions and normal control. In patients with CIN, the assumption of the estro-progestinic pill does not seem to contribute to the increase of frequency of cervico-vaginal infections.

Adolescent↗
PubMed1988

Tumoral markers (CA 125--CEA) in the screening of ovarian cancer.

Ovarian cancer has high rate of mortality among malignant gynecologic tumors. Because of its aggressiveness and low rate of 5 year survival of patients treated, it is important to realise a screening program for its early diagnosis. Today, immunologic research is directed to the study of tumoral markers that allow us to detect the presence of still clinically silent ovarian neoplasms. Some tumoral markers such as CEA and CA 125 are available for post-surgical monitoring of patients treated for ovarian cancer. The Authors have carried out a study to evaluate the possibility of their use in the depistage of ovarian neoplastic pathology. A blood sample was taken for the evaluation of serum CEA and CA 125 in a series of 520 patients older than 45 years, who did not complain signs or symptoms of pelvic pathology. A pathologic value for CEA was considered higher than 7.3 ng/ml and for CA 125 greater than 37 U/ml. For CEA 2.5% (13 cases) presented pathologic values compared to 2.88% (15 cases) for CA 125. One third of cases (0.5%) with high levels of CEA had repeated blood samples. 3 of them had confirmed high levels of CEA but echotomography performed in these patients was negative for pathologic ovarian masses. 15 patients had CA 125 high levels. 3 out of 15 cases repeated the blood sample that resulted normal. On 11 of these cases an echotomography was also performed that diagnosed a uterine myomatosis in 4 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1988

Ovarian tumours: anatomohistopathological contribution to their interpretation.

The data resulting from an epidemiological and anatomopathological study on ovarian tumours in the Trieste province are presented. 970 cases of ovarian neoplasms diagnosed in the Institute of Pathological Anatomy and Histology of Trieste University over the 1969-1985 period were analyzed: 66.7% were benign and 33.3% were malignant. The crude incidence of benign ovarian tumours was 24.2/100,000 and that of malignant tumours was 12.1/100,000. The incidence rate of the latter standardized on the world population was 6.5/100,000. It is a low level, which does not increase over time. Benign ovarian tumours affect all age groups, while malignant tumours are more frequent among elderly women. In addition, the distribution by age group varies according to the histological type. Among benign tumours, the most frequent are the epithelial ones (over 50% of the total), followed by tumours of germinal origin (27.5%), tumours of the ovarian stroma (21.6%) and those of ovarian non-specific tissues (0.8%). Among malignant neoplasms, epithelial ones are 94.4%, germinal tumours 2.8%, stromal tumours 1.8% and sarcomas 0.9%.

Adolescent↗
PubMed1986

Management of intrauterine growth retardation: diagnostic and clinical aspects.

A retrospective analysis of the ultrasonic charts of 150 pregnancies with a birth weight below the tenth percentile is presented. In all cases the first scan was carried out before the 20th week of gestation to assess gestational age measuring crown to rump length or biparietal diameter (BPD). Subsequent scans every 4 weeks measured BPD or abdominal circumference. Birth weight was below the fifth percentile in 70 cases and between the fifth and tenth percentiles in 80 cases. A risk condition was found in 32.26%. The first observation of an abnormal parameter was widely spread throughout the latter half of the pregnancy. The management of IUGR included close observation and often required planned delivery. Cesarean section was required in 30.75% of the cases. Acute fetal distress has been the indication in 17.6% of cases and chronic fetal distress in 41.3%. Perinatal mortality was 6.66%. The need for criteria that will accurately detect the fetus most at risk from complications of IUGR is stressed.

Birth Weight↗
PubMed1986

Diagnostic validity of the Vabra Curettage. Compared study on 172 patients who underwent Vabra Curettage and the fractional curettage of the uterine cavity.

The authors report 172 cases of patients who had to undergo a curettage of the uterine cavity and an endometrial sampling with Vabra Curettage. In 80.8% of the cases, the histologic diagnosis of the material removed with Vabra Curettage was comparable with that of the uterine curettage. In 8.7% of the sampling, the histologic diagnosis of the tissue removed with the "suction technique" was easier. In 10.5% of the cases, the diagnosis was more reliable in the samplings taken away with uterine curettage. In this last group, nevertheless, the endometrial tissue removed with Vabra curettage allowed us to exclude the presence of an adenocarcinoma or of an atypical hyperplasia. Only in 1.2% of the specimens, the Vabra Curettage did not allow us to exclude an endometrial pathology (for lack of material). On account of the increased incidence of endometrial carcinoma, the tolerability of the method proposed, its low cost, the Authors advocate a large-scale use of this method for a prevention program directed at the high-risk population for this carcinoma.

Adenocarcinoma↗
PubMed1985

Breast carcinoma metastasizing to the uterus.

Metastases from mammary carcinoma represent the principal cause of exitus in 45% of subjects dead from this neoplasia. Also if they are not frequent, uterine metastases from mammary carcinoma are not very rare to find at the autopsy (2-15% as various Authors report). In this study, the Authors present 17 cases (1 bioptic and 16 autoptic cases) of uterine metastases from breast carcinoma. The histological examination confirms a more frequent involvement of the uterine corpus, with infiltration of the myometrium. When the endometrium is affected, generally the neoplasia infiltrates the stroma, preserving the glandular architecture. In one case, the uterine metastases was associated with a fibroleiomyoma. The clinical symptomatology (metrorrhagia in 3 of 17 cases) was poor because, as we have said above, generally the neoplasia infiltrates the myometrium.

Adult↗
PubMed1985

Recurrence incidence in follow-up of patients affected by condylomatosis of the uterine cervix with VCE (viral cytopathic effect).

The frequent association of HPV lesions with cytological and/or hystological alterations of CIN in the uterine portio and in the lower genital tract suggests their possible role in the genesis of precancerous lesions of the cervix. In the systematic cytological screening, condylomatous lesions present an incidence varying from 0.52% to 1.5%. With the aim of verifying the incidence rate of condylomatosis of the portio, in the population of the women followed in the Colpocytological Service of obstetrics and gynaecology (Institute for Childhood of Trieste), the authors have performed a retrospective analysis on 17273 colpocytological examinations and have found 72 cases (0.41%) with cytological and/or histological evidence of viral-cytopathic effect produced by HPV. These patients have undergone various treatments of this pathology and have performed a follow-up. In some patients 12 cases, treated only with antiflogistic therapy or no therapy, 50% of these has shown a complete regression of viral infection in the first control after 4 months. In these patients, it is suggestive to suppose that a good immunological reactivity has brought the patient to recovery. For that, in their next work, the Authors will investigate the immunological responsiveness of patients affected by HPV lesions of the cervix.

Colposcopy↗
PubMedDate not supplied

[Report of a case of autoimmune thrombocytopenic purpura in pregnancy].

A clinical report concerning a severe idiopathic thrombocytopenia during pregnancy (minimal platelet count 3000/mm3 is described). Corticosteroids and immunoglobulins were administered in preparation to elective cesarean delivery. Since the platelet count not improve significantly, 3 units of platelets from a single donor were adjunctively given using diapheresis. An elective cesarean delivery was performed at 34 weeks, without further complications. The newborn weighed 2550 g and the postnatal course was uneventful.

Adrenal Cortex Hormones↗