Biomedical subjects

S Anagonou

Publications and source records attributed to S Anagonou.

22 records · Page 2Linked to original sources

PubMed1995

[Mycobacterium ulcerans cutaneous infections: Buruli ulcers].

Mycobacterium ulcerans skin infection or Buruli ulcers are common in children in many rural tropical areas. The usual clinical appearance is a deep, rapidly developing chronic ulcer associated with necrosis of subcutaneous fat. Patients are usually seen at an advanced stage. Bacteriologic identification is not always possible because the pathogen, Mycobacterium ulcerans, is an atypical mycobacteria that is difficult to isolate and grows slowly in culture. Medium although of little assistance in tropical regions, the histological features are highly characteristic and can allow diagnosis in areas in which the disease is rare and unsuspected. The pathogenic effects of Mycobacterium ulcerans are due to the production of a necrotizing exotoxin with an immunosuppressive action. Treatment using antituberculosis and antileprosy drugs has been disappointing. Surgery is usually required and causes extensive sequels in many cases, the best technique being an excision/graft procedure. Many epidemiologic characteristics of Buruli ulcers which are andemic in regions with and aquatic ecosystem are still unclear including the mode of infection, transmission and reservoir. Recent outbreaks, particularly in west Africa, may be related to changes in the natural environment.

Adolescent↗

PubMed1994

[Buruli's ulcer, a pathology little known in Benin. Apropos of 227 cases].

Cutaneous Mycobacterium infection is an endemic disease in Mono, Ouémé and Zou districts in the south of Benin, where it seems rarely known. The authors are reporting the results of a clinical, bacteriological, epidemiological and therapeutical study about 227 patients. Children are the principal targets of this disease. Ulceration are often seen in a critical step (3 or 4) and acid-fast bacilli have been found from 189 of 227 patients tested by bacilloscopy (smear microscopy). Medical treatments (antituberculosis and antileprosis drugs) are still disappointing. Also when necessary, surgery is done (broad excision, skin transplant afterwards) with promising results. However, complications like deformities and flexion contractors can persist after surgical treatment. In the south Benin, Buruli's ulcers are one of the major public health problems.

Adolescent↗

PubMed1994

[Trends in the HIV/AIDS epidemic in Benin (1990-1993].

Since 1990 within the framework of a National Program against AIDS, surveillance in the Republic of Benin has relied on disease-control centers established in 20 selected locations. Seropositivity for HIV is always established by Western-blotting and diagnosis of AIDS is based on BANGUI/WHO clinical criteria and positive serologic tests. On June 30, 1993, the cumulative number of AIDS cases reported to the WHO was 12/100000 inhabitants of Benin. The sex-ratio was 2 to 1 and 77.4% of cases occurred in the 20 to 49 year age range. Heterosexual transmission accounted for 75.8% of cases and mother-to-child transmission for 6.4%. Overall the cumulative number of AIDS cases doubled each year from 1990 to 1992. The prevalence of HIV antibodies in target groups has been steady: less than 1% of blood donors and urban or rural women undergoing prenatal examinations. The prevalence of HIV antibodies has risen significantly every year among patients with tuberculosis and people consulting for sexually transmitted diseases. These findings corroborate the notion that the incidence of positive serologic tests for HIV is low in Benin: less than 1% of the adult population.

Adolescent↗

PubMedDate not supplied

[Cholera in Benin (epidemic of 1991)].

Authors report on epidemiologic, bacteriology and therapeutic data related to 1991 cholera outbreak in Benin in the general context of the 7th world pandemic. 7474 cases were notified from all over the country. Vibrio cholerae 01, El Tor biotype, was identified in many patients stools and in the surroundings. Control measures implemented in this situation are described: early parenteral and mainly oral rehydration, antibiotic treatments for patients and contacts, systematic home control around cases, wells disinfection and general hygiene promotion, mobilization of the Civil Service Authorities and population education. Authors conclude that strict epidemiologic monitoring is necessary in epidemic circumstances as well as during endemo-sporadic period.

Adolescent↗