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Biomedical subjects

S Andersen

Publications and source records attributed to S Andersen.

At least 109 records · Page 6Linked to original sources
PubMed1981

Albumin reserve for binding of bilirubin in maternal and cord serum under treatment with sulphasalazine.

Twelve pregnant patients with ulcerative colitis or Crohn's disease who were being treated with sulphasalazine (SASP) were studied together with their newborn, full-term babies. An earlier study had shown almost identical concentrations of SASP and its metabolic sulphapyridine (SP) in maternal and cord serum. As controls, blood samples were collected from 25 healthy women and their newborn infants. Sera from mothers and infants were analysed for the vacant amount of high-affinity bilirubin binding site on albumin (reserve albumin) by the MADDS method. The mean reserve albumin concentration of the SASP-treated mothers was 9% lower than that of the controls, which is probably insignificant. No difference was observed in the corresponding two groups of infants. In vitro studies showed that neither SASP nor SP in therapeutic plasma concentrations had a significant bilirubin-displacing capacity. It seems that SASP preferentially is bound to other sites on albumin than to the high-affinity binding site for bilirubin. The risk of kernicterus in the full-term newborn does not seem to be increased by treatment of the mother with sulphasalazine.

Adult↗
PubMed1980

Experimental Ascaris suum infection in pigs. Serological response, eosinophilia in peripheral blood, occurrence of white spots in the liver and worm recovery from the intestine.

Experimental oral inoculation of pigs with infective A. suum eggs resulted in eosinophilia in the peripheral blood and a serum antibody response. When pigs were inoculated at 3 days of age the antibody response was depressed which is suggested to be due either to a protective effect of colostral antibodies or to an immunologic incompetence of the young pigs. Despite the use of isolated pens and strict hygienic measures it was difficult to obtain an Ascaris free environment for the experimental animals. The pathogenesis of white spots in the liver is assumed to represent an immune reaction by the host. Multiple white spots were demonstrated when pigs were inoculated with several egg doses provided the livers were examined 1--3 weeks after last inoculation. The rapid healing of white spots implies that the finding of many white spots in the liver at slaughter indicate a recent uptake of infective A. suum eggs. The finding of low intestinal worm burdens in the experimental pigs after repeated oral inoculations indicates a specific, acquired resistance. Resistance to A. suum in pigs is suggested to involve co-operation of the humoral and the cell mediated immune system and the parasite is eliminated both during migration by white spot formation in the liver and during the early prepatent period by expulsion from the gut.

Animals↗
PubMed1979

The epidemiology of primary osteoarthrosis of the knee in Greenland.

Two hundred ninety-five Greenlanders, 5% of the population of Greenland, aged 40 years or more, were investigated regarding primary osteoarthrosis of the knee. The pathological changes were categorized as mild, intermediate, or severe. Eighty-six (29%) of the patients were found to have osteoarthrosis and the mild form accounted for 72% of these, while only one individual was found to have severe osteoarthrosis. Significantly more individuals from the West coast of Greenland (a mixed Eskimo-European population) than individuals from the East coast (genuine Eskimos) were found to have osteoarthrosis of the knee (38% and 18%, respectively). An investigation of the sex distribution revealed more soteoarthrosi among West coast women than among East coast women (P less than 0.05), whereas no such differences were found among the men. It was speculated that the difference between the rates of osteoarthrosis of the knee in the two population groups might reflect differences in occupation and possibly also a genetic predisposition.

Age Factors↗
PubMed1978

The epidemiology of primary osteoarthrosis of the knee in Greenland.

295 Greenlanders, 5% of the population of Greenland, in the age group 40 years or more, were investigated regarding primary oesteoarthrosis of the knee. The pathological changes were categorized as mid, intermediate, or severe. 86 (29%) of the subjects were found to have osteoarthrosis and the mild form accounted for 72% of these, while only one individual was found to have severe osteoarthrosis. Significantly more individuals from the West coast of Greenland (a mixed Eskimo-European population) as compared with individuals from the East coast (genuine Eskimos) were found to have osteoarthrosis of the knee (38% and 18%, respectively). An investigation of the sex distribution revealed more osteoarthrosis among West coast women than among East coast women (p is less than 0.05), whereas no such differences were found among the men. It was speculated that the difference between the prevalence rates of osteoarthrosis of the knee in the two population groups might reflect differences in occupation and possibly also a genetic predisposition.

Adult↗
PubMed1976

[The influence of Ascaris suum infection upon growth rates in pigs (author's tranls)].

The influence of experimental Ascaris suum infection upon growth rates in pigs has been studied in two experiments with disease-free pigs. In pigs where a patent Ascaris infection was established growth rates were decreased by appr. 20% compared with parasite-free controls. The experiments have revealed that the negative influence of Ascaris suum upon growth is caused both by the larvae during migration through the lungs and by the presence of adult worms in the intestine.

Animals↗
PubMed1975

Socio-medical follow-up examination of 1 143 greenlanders surgically treated for pilmonary tuberculosis at Queen Ingrid's Hosptial at Godthåb in the years 1954-1966.

A follow-up examination of 1 143 Greenlanders operated on for pulmonary tuberculosis in the years 1954-66 is reported. The main group consists of 785 resected patients. At follow-up 2=12 years after operation all patients were traced. One hundred and four (9 percent) had died; the remaining 1 039 had all been restored to health. Ninety percent of the ex-patients were fully or partially fit and 1 percent unfit for work. Length of observation, time of resumption of work, reasons for change (if any) of occupation, work capacity in relation to the nature of the surgical interventions, and the patients genreal condition as well as housing situation are discussed. National assistance in Greeland is mentioned in brief.

Age Factors↗