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Biomedical subjects

S Anil

Publications and source records attributed to S Anil.

At least 37 records · Page 2Linked to original sources
PubMed1993

Quantitation of circulating immune complexes in patients with chronic periapical lesions.

Quantitation of circulating immune complexes (CIC) was done in 45 patients with chronic periapical lesions. The levels were compared with those of age-matched healthy individuals. Both patients with chronic periapical granuloma and periapical cysts showed significantly higher levels of CIC than the controls. This observation indicates that the continuous presence of root canal antigens may cause elevated levels of circulating immune complexes. The possibility of chronic periapical lesions acting as foci of infection is discussed, and the importance of early treatment of these conditions is emphasized.

Adult↗
PubMed1993

Total hemolytic complement (CH50) and its fractions C3 and C4 in the sera of patients with localized juvenile periodontitis.

The total hemolytic complement activity (CH50) and its fractions C3 and C4 levels were determined in the sera of 21 subjects with localized juvenile periodontitis (LJP). Total hemolytic complement activity was expressed as number of CH50 units per ml of blood, while C3 and C4 levels were assessed by radial immunodiffusion and expressed as mg%. The values were compared with an equal number of age- and sex-matched periodontally healthy controls. The results indicate a significant increase in CH50, C3, and C4 levels in the sera of patients with LJP. The study reveals the participation of complement system in the pathogenesis of LJP, and its assessment may assist in understanding the relative importance of complement activities in the disease process.

Adolescent↗
PubMed1993

Hyalinosis cutis et mucosae--a case report.

Hyalinosis cutis et mucosae is a rare genetic disease characterized by accumulation of glycoproteinaceous material at mucocutaneous sites, salivary glands, central and peripheral nervous systems, eyes, other organs and tissues. The course of the disease is protracted and not likely to regress either spontaneously or with therapy. The disease may produce considerable disfigurement and functional impairment. The morbid factors include disfiguring papulonodular lesions particularly of expose skin, hoarseness of voice due to vocal cord. Infiltration, nodular deformation of the eyelids and board like rigidity of tongue. A case of Hyalinosis cutis et mucosae in a 18 year old girl is reported here. The clinical features, histopathology and management are discussed in detail.

Adolescent↗
PubMed1990

Cell-mediated and humoral immune response in diabetic patients with periodontitis.

Cell-mediated and humoral immune responses were assessed in 50 patients with type II or non-insulin-dependent diabetes mellitus and 50 nondiabetic patients with periodontitis. The values were compared with those of 50 age and sex-matched control subjects. The cell-mediated immunity assessed by enumerating the total and high-affinity rosette-forming cells of the patient did not show any significant variation from that of the normal control subjects. The humoral immune response was assessed by estimating serum immunoglobulins G, A, M, D, and E by single radial immunodiffusion. Except IgD, all other immunoglobulins were found to be elevated significantly in both diabetic and nondiabetic subjects. The alteration in humoral immune response may be the cause or the effect of periodontitis. The defective host response reported in diabetic patients may be responsible for the increased incidence of periodontitis in diabetic patients as compared to nondiabetic patients.

Adult↗
PubMed1990

Total hemolytic complement (CH50) and its fractions (C3 and C4) in the sera of diabetic patients with periodontitis.

The total hemolytic complement activity (CH50) and its fractions C3 and C4 were determined in 50 patients with Type II or non-insulin dependent diabetes mellitus (NIDDM) and 50 nondiabetic patients with periodontitis. The values were compared with those of 50 age and sex matched controls. An elevation of CH50 was observed in both the diabetic and nondiabetic patients, compared to controls. The diabetic patients with periodontitis showed a significantly higher complement activity compared to nondiabetic patients with periodontitis. The C3 and C4 values were significantly elevated in both diabetic and nondiabetic patients when compared with the control group. The elevation being more pronounced in diabetic groups.

Adult↗
PubMed1990

Circulating immune complexes in localised juvenile periodontitis.

This study determined the quantity and type of circulating immune complexes (CIC) in the sera of 15 patients with localised juvenile periodontitis (LJP). There was a significantly higher level IgG and IgM in LJP patients as compared with the controls. The possible role of CIC in the pathogenesis of juvenile periodontitis is discussed.

Adolescent↗
PubMed1990

Cell-mediated and humoral immune responses in patients with localized juvenile periodontitis.

Cell-mediated and humoral immune responses were assessed in 21 patients with localized juvenile periodontitis (LJP), and in an equal number of control subjects. The cell-mediated immunity, assessed by enumeration of total rosette forming cells [TRFC] and high affinity rosette forming cells [HARFC], was found to be depressed in LJP patients compared to controls. Estimation of serum immunoglobulins G,A,M,D and E levels were done using single radial immunodiffusion. All the immunoglobulins except IgD were found to be elevated significantly in LJP patients. The defective immune response found in LJP patients may be the cause or effect of the disease process. Further investigations are necessary to determine whether these defects are genetically controlled.

Adolescent↗
PubMed1990

Circulating immune complexes in diabetic patients with periodontitis.

Circulating immune complexes were estimated in the sera of 50 patients with Type II or non-insulin-dependent diabetes mellitus (NIDDM) and 50 nondiabetic patients with periodontitis. The values were compared with that of 50 age- and sex-matched controls. There was a significant rise in circulating immune complexes (CIC) in both the groups of patients compared to controls. The levels of CIC were significantly higher in diabetic patients with periodontitis compared to nondiabetics. The study shows that the circulating immune complexes may have a role in the pathogenesis of periodontal disease in diabetic patients.

Adult↗
PubMed1989

Oral myiasis: a case report.

A case of oral myiasis which was caused by the Diptera species is reported. The case is discussed in relation to its clinical presentation, etiopathogenesis, management and prognosis.

Aged↗
PubMed1988

A rare human model for oncogenesis.

A rare female human model of oral carcinoma (OC) who refrained from any type of tobacco and/or betel nut habits, belonged to an younger age group, had no pre-existing precancerous lesions in the oral cavity and who was exposed chronically to cashew nut oil, is presented. The role of genetic inherited influences, occupational and endocrine disturbances with racial factors in the causation of oral carcinoma is discussed. The significance of further studies at the genetic level, to rule out protooncogenic activation in the causation of oral cancer is summed up. The literature on the concept of oncogenesis is reviewed briefly.

Adolescent↗
PubMedDate not supplied

Expression of lectin binding in oral submucous fibrosis.

Lectins are a group of specific glycoproteins present in cells, particularly cell membrane. Recently, lectin binding studies have been used as a diagnostic as well as prognostic indicator of neoplasm's. Oral submucous fibrosis (OSMF) is a potential premalignant condition predominantly seen in Indian subcontinent. A comparison of expression of lectin binding was studied in normal tissue, OSMF cases and oral squamous cell carcinoma. The OSMF cases were grouped into early and advanced conditions as per the histopathologic criteria. Patterns of lectin binding observed with advanced OSMF cases were comparable with that of Oral squamous cell carcinoma. The role of lectin binding studies in assessing the malignant potential of a pre-malignant condition is discussed.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Current research in diagnostic methods for assessing periodontal disease.

The management of chronic periodontal disease is beset with a numbers of diagnostic as well as therapeutic problems. Assessment of periodontal disease progression has been made mainly based on the conventional methods such as clinical parameters and radiographic interpretation. A high level interest in the development of diagnostic tests capable of detecting factors associated with progressing periodontal disease has continued in the past years. Recent research has shown evidence that certain microbial species and specific genetic and related factors are some strong indicators of susceptibility to severe periodontitis. Here an attempt is made to review the current trends and diagnostic tests used to assess the disease activity and predict its progression.

Clinical Enzyme Tests↗
PubMedDate not supplied

Tuberculous ulcer of the tongue as presenting feature of pulmonary tuberculosis and HIV infection.

Tuberculosis (TB), once a lethal disease, has shown a decrease in incidence with improved public health measures and availability of antituberculous drugs. But with the advent of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), it has re-emerged alarmingly as an opportunistic infection in immunocompromised patients. Lungs are the most commonly affected organs and involvement of the oropharyngeal region in TB is very rare. Two cases of TB manifesting as ulcer of the tongue are reported here. Interestingly, both of these cases were reported within a span of six months and both of the patients were in their early thirties. A primary diagnosis of both pulmonary TB and HIV sero-positivity was made after the diagnosis of the oral TB ulcer.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

Immunology of chronic generalized periodontitis. 2. Estimation of total hemolytic complement (CH 50) and its fractions C3 and C4.

The total hemolytic complement activity (CH50) and its fractions C3 and C4 were determined in forty patients with chronic generalized periodontitis (CGP). The values were compared with an equal number of age and sex matched periodontally healthy controls. Total hemolytic complement activity was expressed as number of CH50 units per ml of blood, while C3 and C4 levels were assessed by radial immunodiffusion and expressed as mg%. The observations showed a significant increase in CH50, C3 and C4 levels in the sera of patients with CGP. The study reveals the role of complement system in the pathogenesis of chronic generalized periodontitis.

Adult↗
PubMedDate not supplied

Plant lectins--histochemical and cytochemical applications in oncology.

Lectins are sugar binding proteins or glycoproteins of non-immune origin derived from various plants or animals with specific sugar binding capacity. This property of lectins can be used to identify structural differences between normal and malignant cells. Malignant transformation is accompanied by several changes in cell membrane. Studies have shown that the lectin binding pattern of these cells may indicate the invasive potential of tumours. Lectins can also be used as carriers. Lectins conjugated to chemotherapeutic agents has been found to be more useful in the treatment of tumours induced in animals.

Agglutination Tests↗
PubMedDate not supplied

Immunology of chronic generalized periodontitis. 1. Estimation of cellular and humoral immune status.

Cell-mediated and humoral immune responses were assessed in forty patients with chronic generalized periodontitis (CGP), and in an equal number of control subjects. The cell mediated immunity assessed by enumeration of total rosette forming cells [TRFC] and high affinity rosette forming cells [HARFC], were found to be slightly depressed in CGP patients compared controls. The humoral immune response was assessed by estimation of serum immunoglobulins G,A,M,D and E by single radial immunodiffusion technique (RID). Except IgD all the other immunoglobulins were found to be elevated significantly. These immunological derangements found in CGP patients may be the cause or effect of the disease process.

Adult↗
PubMedDate not supplied

Melanotic neuroectodermal tumor of infancy. Report of a case.

A case of melanotic neuroectodermal tumor of infancy involving the right maxillary alveolar ridge region of a 4 month old girl is reported. Clinical, histopathological and laboratory findings supported the diagnosis. This case had high levels of urinary excretion of vanilmandelic acid (2.8 mg/24 hrs.) and serum alpha-fetoprotein (210 mg/ml); which are characteristic of this tumor.

Alveolar Process↗