PubMed Health⌕ Search

Biomedical subjects

S Aractingi

Publications and source records attributed to S Aractingi.

17 recordsLinked to original sources
PubMed1992

[Methotrexate-induced skin detachment].

The undesirable effects of high-dose methotrexate on integument and mucosa are well-known, but lesions of the skin proper, characterized by distal erythema with desquamation, are rare. We report the case of a male patient presenting with extensive skin erosions after intravenous infusion of a 5 gram total dose of methotrexate to treat high-grade lymphoma. The skin disease was accompanied by renal, hepatic and mucosal lesions, as well as bone marrow aplasia. The mechanism of cutaneous necrosis is uncertain, but it might be due to direct toxicity of methotrexate to the epidermis. The patient was also treated with G-CSF. He recovered from aplasia within 6 days, without infectious complications. Haematopoietic growth factors might have reduced the risk of infection arising from the skin, by shortening the duration of cytopenia.

Acute Kidney Injury↗
PubMed1992

Acral persistent papular mucinosis and IgA monoclonal gammopathy: report of a case.

The case of a 60-year-old man with acral persistent papular mucinosis (APPM), thought to represent a new distinctive form of dermal mucinosis not associated with systemic diseases, is reported. The patient had a 4-year history of multiple small papular lesions on the distal forearms, wrists and back of the hands. Histologically, mucin deposits in the upper and mid dermis sparing a superficial subepidermal grenz zone were observed. In contrast to previously described cases, a monoclonal IgA of kappa light chain isotype was detected. Our findings challenge the view that absence of paraproteinemia is a peculiar characteristic of APPM and raise once more the question of its relationship to the discrete papular form of lichen myxedematosus.

Diagnosis, Differential↗
PubMed1992

Keratosis follicularis spinulosa decalvans: report of a case with ultrastructural study and unsuccessful trial of retinoids.

Keratosis follicularis spinulosa decalvans (KFSD) is a genetic disorder characterized by disseminated follicular hyperkeratosis, especially localizated to scalp and face. We report the case of a new patient displaying typical features of KFSD. Ultrastructural study was performed and displayed round keratohyalin granules in follicular keratinocytes. Trial with etretinate, which has not been reported before in this disease, proved to be ineffective.

Biopsy↗
PubMed1992

[Deep lupus erythematosus in children].

Deep cutaneous lesions are seldom encountered in lupus erythematosus. The disease described in the literature as lupus erythematosus profundus or lupus erythematosus panniculitis usually occurs in middle-aged women. The authors report a case of deep lupus erythematosus which was exceptional in that it occurred in an 11-year old girl. The lesions were situated on the face and consisted of solid subcutaneous nodules and clear-cut ulcerations leaving atrophic pigmented scars. The histological image of a nodule was one of lobular lymphocytic panniculitis with homogeneous hyalinization of adipose nodules, to which must be added periadnexal and perivascular dermo-epidermal lymphocytic infiltrates. Granular IgM deposits arranged along the dermo-epidermal junction were observed at direct cutaneous immunofluorescence. Laboratory examinations showed leucopenia (3,300/mm3) with neutropenia (1,100/mm3) and the presence of antinuclear antibodies at 1/100 speckled fluorescence, as well as antibodies directed against native DNA. Studies of renal function and for complement gave normal results. The other causes of lobular panniculitis were excluded. The lesions regressed within 3 weeks under hydroxychloroquine; this drug was also successful in arresting a relapse consecutive to withdrawal of treatment. The authors have analysed the 17 paediatric cases of deep lupus erythematosus and were able to determine their main characteristics: 1. The lesions occur mostly in girls (70 p. 100). They are located electively on the face and the lateral aspect of the shoulders. They consist of well-limited, solid or hard subcutaneous nodule which may congregate to form plaques. The epidermis may be normal or pathological, poikilodermic, looking like a discoid or ulcerated lupus erythematosus. The lesions regress, leaving a characteristic atrophic scar.(ABSTRACT TRUNCATED AT 250 WORDS)

Antibodies, Antinuclear↗
PubMed1991

[Clinical aspects commented on].

Psoriasis is a chronic and common disease (prevalence of 1/1000 in France). It is therefore highly probable that it will be encountered by all non-dermatologists in their practice, hence the necessity for them to be able to recognize its principal forms. The clinical presentations of psoriasis are multiple and varying in their severity. In any given patient flare-ups may constantly be similar or change in the course of time. In the vast majority of cases skin lesions are typical, leading to a purely clinical diagnosis without need for additional investigations, and treatment can be instituted. In some case, however, the lesions are atypical and the diagnosis is doubtful. This is where histological skin biopsy can be of considerable help. Finally, other skin lesions may resemble psoriasis and be misleading; here again, histology or some other laboratory examinations will provide the correct diagnosis. In this chapter all these situations are presented be means of photographs accompanied with comments, which illustrate the semeiological and clinical diversity of psoriasis.

Humans↗
PubMed1991

[Bronchial complications of primary humoral immunodeficiency].

Primary humoral immunodeficiency is characterized by an abnormal immunoglobulin production. More than twelve forms are now known and a reviewed by the authors. The deficiency is responsible for bronchial infections which in the long term may result in bronchiectasis. It may also result in benign follicular hyperplasia. The specific treatment is substitutive and not devoid of hazards.

Agammaglobulinemia↗