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Biomedical subjects

S Aronoff

Publications and source records attributed to S Aronoff.

18 recordsLinked to original sources
PubMed1995

Opsoclonus myoclonus syndrome secondary to Epstein-Barr virus infection.

We report the first two children to have the "opsoclonus myoclonus syndrome" after a serologically confirmed acute Epstein-Barr virus infection. Although opsoclonus was absent in one patient, both patients had all other features typical of this syndrome. Patients without opsoclonus have been described as having an isolated postinfectious myoclonus syndrome but probably lie within the spectrum of opsoclonus myoclonus syndrome. The prognosis for the opsoclonus myoclonus syndrome in children with Epstein-Barr virus infection and without evidence for a neuroblastoma appears to be better than in those patients where a cause cannot be identified.

Antibodies, Viral↗
PubMed1994

Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children.

The safety and efficacy of clarithromycin was compared with those of amoxicillin-potassium calvulanate for the treatment of acute otitis media in children. In a multicenter, randomized, investigator-blinded trial, 180 patients (6 months to 12 years of age) with acute otitis media were allocated to receive either clarithromycin, 15 mg/kg in two divided doses (n = 90), or amoxicillin-clavulanate, 40 mg/kg in three divided doses (n = 90), for 10 days. Middle ear samples were obtained by tympanocentesis from 175 of 180 patients. Pathogens were isolated from 137 samples (76%). Eighty-six patients in each treatment group were considered for efficacy analysis. Clinical cure or improvement was achieved within 4 days after treatment in 80 (93%) of 86 patients receiving clarithromycin and in 82 (95%) of 86 patients receiving amoxicillin-clavulanate. Recurrence of infection was observed between 5 and 35 days after treatment in 9 (11%) of 80 patients in the clarithromycin group and in 8 (10%) of 82 patients in the amoxicillin-clavulanate group. Middle ear effusion was found with similar frequency at the end of therapy and at follow-up visits in both treatment groups. Mild gastrointestinal signs and symptoms, the most common side effects, were noted in 20% and 52% of patients in the clarithromycin group and the amoxicillin-clavulanate group, respectively (p < 0.001). We conclude that clarithromycin is a safe and effective antimicrobial agent for the treatment of acute otitis media in children.

Acute Disease↗
PubMed1986

Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin.

The presence of Campylobacter pyloridis in the gastric mucosa was recently linked to peptic ulcer disease. This study compared the inhibitory activity of three macrolide compounds (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin against 10 clinical isolates of C. pyloridis. The macrolides were equally effective against the test strains, with MICs ranging from 0.06 to 0.5 microgram/ml; rifampin was less active, with MICs ranging from 0.25 to greater than 1 microgram/ml. Erythromycin and the two new macrolide derivatives are potentially useful agents in the treatment of infections caused by C. pyloridis.

Adult↗
PubMed1981

Chlorophyllide b.

Explore the source record for details and available documents.

Carboxylic Ester Hydrolases↗
PubMed1977

Biosynthesis of chlorophyll b.

Using [14C]chlorophyll a derived from a mutant of wheat lacking chlorophyll b, spinach thylakoids from very young leaves and cucumber thylakoids of irradiated, etiolated cotyledons convert chlorophyll a to b with apparent yields of 19% and 5%, respectively.

Chlorophyll↗
PubMed1975

Hypnotherapy in the treatment of bronchial asthma.

The efficacy of hypnotherapy in aborting acute asthmatic attacks was studied in 17 children ranging in age from six to 17. All had as their primary diagnosis bronchial asthma. Prior to hypnotic induction pulmonary function was assessed, then monitored in the immediate post hypnotic period and at two intervals thereafter. The average improvement for all subjects was greater than 50% above the baseline measurement as documented by spirometry, monitored dyspnea, wheezing and subjective ratings by the subjects. It is suggested that hypnotherapy may be an important tool in ameliorating asthma, improving ventilatory capacity and promoting relaxation without recourse to pharmacologic agents. One explanation offered is that hypnosis affects an automic response, thereby diminishing bronchospasm.

Adolescent↗
PubMed1967

Boron in plants: a biochemical role.

Boron, as borate, appears to have a role in partitioning metabolism between the glycolytic and pentose-shunt pathways. This effect results from the association of borate with 6-phosphogluconic acid, forming a virtual substrate that inhibits the action of 6-phosphogluconate dehydrogenase. In the absence of borate, the inhibition of the enzyme is released, and excess phenolic acids are formed. These acids also associate strongly with borate and thus develop an autocatalytic system for production of excess phenolic acids which cause necrosis of tissue and eventual death of the plant.

Borates↗
PubMed1965

Catalase: kinetics of photooxidation.

The kinetics of photooxidation of catalase is a four-step consecutive reaction, if each of the four porphyrin moieties acts independently. The rate of enzyme inactivation is a first-order reaction resulting from destruction of a single porphyrin. The kinetics of absorbancy is more complex, depending upon the absorption probabilities of each of the microspecies. With equal probabilities. the log of the sum of the normalized absorptivities is a linear function of time.

Catalase↗