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Biomedical subjects

S Arya

Publications and source records attributed to S Arya.

46 records · Page 3Linked to original sources
PubMed1981

The composition of tuberous sclerosis grey matter.

The chemical analysis of grey matter from a tuberous sclerosis subject indicated the presence of two different types of grey matter based on two distinctly different ganglioside concentrations. Both samples had gangliosides of reduced concentration with an abnormal composition compared to normal grey matter as evidenced from their thin-layer chromatography profiles. Analyses of the glycoprotein fraction from both samples revealed increased glycoprotein content, particularly in total carbohydrate. This observation was consistent with previous studies of angiofibromas and angiomyolipomas.

Brain↗
PubMed1981

Culture of human glomeruli from patients with metabolic or genetic diseases.

Glomeruli from two patients with metabolic disease were cultured and examined ultrastructurally. One patient with neuronal ceroid lipofuscinosis showed intracellular membrane alterations that we have never seen in normal glomerular cells. In contrast, ultrastructural features of glomerular cells from a patient with nonketotic hyperglycinemia did not differ significantly from normal. These initial findings led us to successfully culture glomeruli from a patient with Alport's syndrome (hereditary nephritis). The results of our studies suggest that several metabolic or genetic diseases that affect the kidney could be studied through culture of tissue.

Adult↗
PubMed1981

The cerebro-hepato-renal syndrome of Zellweger: similarity to and differentiation from the DiGeorge syndrome.

A child with the cerebro-hepato-renal syndrome of Zellweger, who was originally diagnosed as having the DiGeorge syndrome, was studied and transplanted unsuccessfully with cultured thymus. The pertinent literature is reviewed and the importance of distinguishing the two disorders emphasized. Autopsy studies reveal that transplanted cultured thymic fragments can attract lymphoid aggregates as early as 2 wk after transplantation.

Abnormalities, Multiple↗
PubMed1980

The G syndrome--additional observations.

We are reporting the second lethal case of G syndrome occurring in a female. The developmental defects in this patient included posteriorly angulated auricles, bifid tip of tongue with a long frenulum, hypoplasia of the epiglottis and larynx, rocker bottom feet, and hypertrophied labia majora and clitoris. Additional anomalies not previously reported in the G syndrome were circumvallate placenta, and incompletely perforated hymen.

Abnormalities, Multiple↗
PubMedDate not supplied

Renal vein injury during percutaneous transluminal renal angioplasty in nonspecific aortoarteritis.

Percutaneous transluminal renal angioplasty of a right renal artery stenosis in a patient with nonspecific arteritis (Takayasu's arteritis) was performed for the treatment of renovascular hypertension and led to ipsilateral renal vein perforation and massive retroperitoneal bleeding. The mechanism of injury and its relationship to nonspecific arteritis remains obscure. Awareness of this potentially lethal complication is essential because early diagnosis is mandatory for definitive management.

Adolescent↗
PubMedDate not supplied

Percutaneous transpedicular management of discitis.

PURPOSE: To present the technique of percutaneous transpedicular biopsy and debridement of discs in diagnosis and management of discitis. MATERIALS AND METHODS: Fifteen patients underwent disc biopsy through a transpedicular approach with local anesthesia and fluoroscopic guidance. An attempt was made to debride the disc as much as possible. A surgical vacuum drain was deployed through the transpedicular tract when there was persistent drainage. RESULTS: Fifteen patients underwent percutaneous transpedicular disc biopsy and debridement of disc for suspected discitis. Three patients underwent biopsy only and 12 underwent percutaneous discectomy. Six patients had at least one positive culture. Eight patients who underwent discectomy had immediate improvement of pain or neurologic symptoms, obviating emergency surgical debridement of the disc. Four patients did not improve and underwent surgical debridement and fusion. CONCLUSIONS: Transpedicular biopsy of the disc is an effective technique for adequate tissue retrieval and diagnosis of discitis. Adequate debridement in selected patients with antibiotic therapy may be definitive. Epidural extension of discitis and massive vertebral destruction precludes percutaneous treatment.

Adult↗