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S Ategbo

Publications and source records attributed to S Ategbo.

33 records · Page 2Linked to original sources
PubMed1996

[Contribution of endosonography to the diagnosis and follow-up of pediatric gastric neurofibroma revealing von Recklinghausen's disease].

BACKGROUND: Gastrointestinal involvement in von Recklinghausen's disease (RD) is rare during childhood; its symptoms are late and its prognosis is poor, related to local recurrence and risk of malignant transformation. CASE REPORT: A 13 year-old boy was admitted for hematemesis revealing gastric ulcer. A second episode of hematemesis led to identify a sessile gastric tumor in this patient having numerous skin café-au-lait spots. Recurrent bleeding required laparotomy that showed diffuse infiltration into the anterior gastric wall: histological examination of the excised piece showed characteristic features of neurofibromatosis. The patient was not compliant to the endosonographic survey so that a symptomatic relapse led to total gastrectomy: histological examination did not show malignant transformation. CONCLUSION: Endoscopy is a major tool for identifying gastrointestinal localization of RD but endosonography is necessary to precise the extent of the tumor.

Adolescent↗
PubMed1996

Association of HLA class II genes with susceptibility to Crohn's disease.

BACKGROUND: Published studies on the association between HLA class II genes and inflammatory bowel disease are contradictory perhaps because of the limited size and ethnic heterogeneity of the populations studied. AIM: To compare the frequencies of HLA class II genes in a large number of French patients with Crohn's disease and in an ethnically matched control group. METHODS: 344 patients (196 F, 148 M, mean age 23.6 years) with Crohn's disease were molecularly genotyped for the HLA-DQB1 and DRB1 alleles. The results were compared with those for an ethnically matched control population of 488 white adults. RESULTS: There were two significant variations of alleles at the DQB1 locus: an increase in DQB1*0501 allele frequency (chi 2 = 10.6, corrected p value (pc) = 0.01, odds ratio (OR) = 1.61) and a decrease in DQB1*0602/0603 allele frequencies (chi 2 = 8.43, pc = 0.037, OR = 0.66). DRB1 analysis showed associations with three allelic variations: an increase in the frequencies of DRB1*01 (chi 2 = 12.86, pc = 0.003, OR = 1.75) and DRB1*07 alleles (chi 2 = 11.18, pc = 0.008, OR = 1.58) and a very significant decrease in that of the DRB1*03 allele (chi 2 = 19.7, pc = 9.10(-5), OR = 0.46). CONCLUSION: The alleles DRB1*01 and DRB1*07 are associated with susceptibility to Crohn's disease. The strong negative association between the DRB1*03 allele and Crohn's disease suggests that the HLA-DRB1*03 allele mediates 'resistance' to Crohn's disease.

Adolescent↗
PubMed1996

Percutaneous endoscopic gastrostomy in children: influence on gastroesophageal reflux.

OBJECTIVE: Few data exist in the literature about the relationship between percutaneous endoscopic gastrostomy (PEG) and gastroesophageal reflux (GER) in children, and the data that do exist are contradictory. The aim of the present study was to evaluate the effect of PEG on GER. METHODS: Twenty children underwent PEG for enteral nutrition. They were 55 +/- 55 months old and weighed 13 +/- 10 kg. A pH study was performed before and after PEG without treatment when GER status was unknown (n = 10) or under treatment (n = 10) if previous GER was demonstrated. In these cases, the pH study was performed under the same treatment before and after PEG. RESULTS: Six pH studies had abnormal results before PEG. After PEG, the GER of these 6 children significantly improved after the treatment was intensified (n = 50 or spontaneously normalized (n = 1). Results of 13 pH studies that were previously normal remained normal. Only one child with a normal reflux index before PEG had GER after it. For the 20 children, the mean reflux index did not change significantly after PEG (5.5% vs 5.6%). CONCLUSION: Contrary to surgical gastrostomy, PEG does not worsen GER. Therefore, GER is not a contraindication to PEG.

Adolescent↗
PubMed1995

[Nasal transepithelial difference of potential in mucoviscidosis. Clinical application of the measurement].

OBJECTIVES: To demonstrate the value of nasal transepithelial potential difference measurements in the diagnosis and assessment of therapeutic effect in cystic fibrosis. METHOD: Nasal transepithelial potential difference was measured in 50 patients with cystic fibrosis (mean age 10 years) and 21 controls (mean age 8 years). RESULTS: There was a very significant increase in nasal transepithelial potential in cystic fibrosis patients (-28 +/- 8 mv) compared with controls (-8 +/- 3 mv) (p < 0.0001). The sensitivity and specificity of this test for the diagnosis of cystic fibrosis were 92% and 95% respectively. Nasal transepithelial potential difference was positively correlated with age (r = 0.43; p < 0.002) in cystic fibrosis patients but no correlation was found in controls. There was no significant difference in potential differences as a function of sex or Delta F508 genotype (homozygous vs heterozygous; Delta F508 vs non-Delta F508). CONCLUSION: These findings demonstrated the value of transepithelial potential difference in the diagnosis of cystic fibrosis and emphasized its capacity to assess the effect of new therapeutic protocols aimed at modifying C1- and Na+ ion transport. It could be particularly helpful for the interpretation of doubtful sweat tests.

Adolescent↗
PubMed1995

[Bacteriological monitoring of the treatment of Pseudomonas aeruginosa infections with amikacin administrated at once-daily dosis in patients with cystic fibrosis].

The interest of the treatment with a single daily dose of amikacin (AMK) in cystic fibrosis (CF) patients with P. aeruginosa infections has been much debated. The aim of work was to study the efficiency of this treatment on (CF) patients with chronic bronchopulmonary P. aeruginosa infections previously treated for two weeks with the combination ceftazidime (CAZ 200 mg/day in 3 inj. IVD) and AMK (35 mg/day in one IV perf. of 30 minutes). The bacteriological supervision of this treatment was performed 1: by the determination of MICs before and after treatment, 2: by the decrease of P. aeruginosa colonization immediately after this treatment and during 11 months, 3: by the identification of P. aeruginosa strains with phenotypic methods (serotyping and antibiotyping) and with genotypic method (pulsed field gel electrophoresis). The use of AMK in a single daily dose in order to treat chronic lung infections colonized with P. aeruginosa susceptible to this antibiotic shows encouraging results as far as bacteriology is concerned: this treatment has given means to reduce colonization for a month in 15 of 18 patients. For 9 of the 18 patients, no P. aeruginosa strains were isolated for nine months. The serotyping and antibiotyping systems do not enable us to study the P. aeruginosa epidemiology. Genome macrorestriction fingerprinting of P. aeruginosa in pulsed field gel electrophoresis confirms that patient with CF were colonized with one or several clones. In our study no variation of these clones was noticed for the first eleven months. Genome macrorestriction fingerprinting appears to be one of the most effective methods for delineate strains of P. aeruginosa colonizing CF patients.

Adolescent↗
PubMed1994

Duodenal and esophageal manometry in total colonic aganglionosis.

Eleven children with total colonic aganglionosis were studied by esophageal and duodenal manometry. They were separated into two groups: group 1, with ileal involvement, and group 2, without ileal involvement. The results of the digestive motility studies were compared with the extent of ileal involvement of the aganglionosis and with the amount of artificial nutritional support required. All children showed abnormalities on both esophageal and duodenal manometry, suggesting complete digestive tract motility involvement. Recent advances in understanding Hirschsprung's disease and manometrial abnormalities suggest a primary motility disorder in children with total colonic aganglionosis.

Child, Preschool↗
PubMed1991

[Carriage of Streptococcus B in the mother and infant pair at birth. Apropos of 106 cases].

Streptococcus of group B found in the upper respiratory tract, the genito-urinary tract and the intestines of humans and animals is responsible for peri- and neonatal infections with serious outcomes: septicemia, meningitis. In Togo, the high frequency of neo-natal infections brought us to question the importance of streptococcus B in the mother-child couple at birth and to undertake a study conducted simultaneously in two maternities in the city of Lomé. During 8 weeks, from 19 March-19 May we studied 100 mother-child couples and 300 placentas. The following laboratory samples were taken: from the mother a vaginal smear during labor at 5 cm dilatation and rectal swabbing, from the new-born, a swabbing of the outer ear canal and an aspiration of gastric liquid, a fragment of the placenta taken under conditions of surgical asepsis. The results obtained prove that streptococcus B play an important role in the mother-child couple in Togo. The authors propose that more systematic research be conducted on children at birth with regard to this issue.

Carrier State↗
PubMed1991

[Risk factors for the development of diarrhea in children of 6-36 months carrying enteropathogenic microbes (apropos of 130 cases observed in Lomé-Togo)].

Diarrhoea, an important cause of infant morbidity and mortality is a priority problem in developing countries. The diarrhoea is most often of infectious origin. This is an evaluation of the parameters susceptible of influencing the carrying of enteropathogenic agents and the apparition of diarrhoea in children 6-36 months of age living in urban and peri-urban areas in the tropics. The study concerns 130 children divided between well nourished and malnourished. To the parameter "nutritional status" most often used in the different studies one finds in the literature, we chose to add a combination of others regrouped under the categories of "type of feeding" and "environmental factors". In our socio-cultural context, these last two parameters are intimately linked to the mother who lives in symbiosis with her child at least until 36 months of age. At the end of the study we were able to put together the results of research on carriage of a large gamut of enteropathogenic agents (parasites, bacteria, viruses) with our chosen parameters. This allowed us observe all the interactions between these two variables, particularly relating to onset of diarrhoea. We were thus able to conclude that the factors characterizing "Food hygiene and environmental hygiene play the most important role whatever the nutritional status of child".

Carrier State↗
PubMed1991

[Routes of care and health of children in Togo].

A character of child health in the tropics is that benign diseases elsewhere become serious and even mortal. Thus, in spite of considerable pediatric care in Togo, diarrhoea, malaria, anaemia, malnutrition, and acute respiratory illness remain prevalent and comprise a formidable "gang of 5" for pediatric pathology. The behaviour patterns of families and the population in general confronted by illnesses may in part be responsible for this situation. A survey was conducted over 3 months and based on a questionnaire given to parents bringing their children for consultation at the hospital (CHU) of Lomé. The following proved important aspects concerning the care of sick children: 1) many communities call upon health centers, only when other avenues of health care have failed. The number of emergency cases presenting themselves is therefore increased markedly, as is the number of deaths; 2) malaria and diarrhoea are the main offenders, while less than half the children affected use chloroquine or RVO; 3) self-medication and traditional medicine dominate alternative health care strategies. As a result, access to official health resources is retarded. In conclusion, the efficiency of prophylactic and curative health care would be improved if simple preventive measures were employed at all levels and based upon cultural values adapted to individual populations.

Age Factors↗