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Biomedical subjects

S Atkinson

Publications and source records attributed to S Atkinson.

65 records · Page 4Linked to original sources
PubMed1981

The stimulation of thyroid hormone secretion in vitro by thyroid-stimulating antibodies.

A new simple technique is described for the in vitro assay of thyroid-stimulating antibody (TSAb) in serum. Thyroid slices are incubated with serum in two-compartmental dialysis pot, followed by measurement of the thyroid hormone concentration in the dialysis fluid by RIA. Heat-inactivated normal serum applied directly to the tissue has no effect on the basal level of response. A dose-dependent relationship is demonstrated for both TSH and TSAb. Serum from patients with untreated Graves' hyperthyroidism is clearly shown to stimulate thyroid hormone secretion. Porcine thyroid tissue has been used and responds well to TSAb. This technique not only has the advantage of simple methodology, but also reflects the biological activity of TSAb. Therefore it will prove useful for further studies of the significance of TSAb and the pathogenesis of Graves' disease.

Animals↗
PubMed1977

Effects of septal lesions on shock thresholds in weanling male and female rats.

Twenty-four-day old weanling male and female rats were either lesioned in the septal area, gonadectomized, lesioned and gonadectomized, or untreated. Tests for reactivity to electric shock were conducted at 26 and at 40 days of age. Neither males nor females showed any effect of the lesions are measured by flinch and jump thresholds to electric shock immediately following surgery; both male and female lesioned groups showed a significant lowering of thresholds when tested at 40 days of age. The effects of septal lesions on response to electric shock were dissociated from the effects on hyperemotionality measured over the same period of time after the lesions, and appeared to have their effect independent of the sex or hormonal condition of the animals.

Animals↗
PubMed1976

Effect of isolation on barbiturate anaesthesia in the rat.

The duration of barbiturate-induced sleeping in rats was found to be reduced by isolation housing. It was also lower in males than females, and lower in the dark phase of the diurnal cycle. These variables were shown to be additive in their effects. Sex differences in barbiturate action were found to be reduced by gonadectomy in males; and the effects of isolation were found to depend upon housing conditions at the time of testing rather than upon early rearing environment. The implication for theories of arousal is discussed.

Anesthesia↗
PubMedDate not supplied

[A nutritional survey in Tibet].

We present the most striking results of a nutritional assessment held in Tibet from May to July 1990, performed at the request of the Health Authorities of the Tibet Autonomous Region. Using a cut-off value which adjusts for the haemoglobin increase with increasing altitude, 40% of the women of reproductive age were considered anaemic. However, the distribution of their haemoglobin values was gaussian with a mean value of 13.6%. Apparently, the Tibetans respond differently to high altitude, compared to other populations living at high altitudes. Goitre remains a problem despite the goitre control program. Rickets, investigated by clinical signs, was prevalent in 9.2% of the children 0 to 6 years old. Rural children were shorter and lighter than urban ones and started to accumulate their deficit earlier.

Adolescent↗
PubMedDate not supplied

Commissioning conferences: a consultative approach to purchasing.

In 1991 the South East London Health Authority developed a process called 'commissioning conferences' to help them purchase services. The first commissioning conference was used to produce a specification of service for people with diabetes mellitus. For this, 120 local people and 15 independent experts were consulted in a structured way.

Congresses as Topic↗
PubMedDate not supplied

Eye glasses and dentures in the O.R.: the choice is yours!

Historically, patients have been required to remove their dentures and eye glasses on the pre-surgical ward before being taken to the Operating Room (OR) on the day of surgery. This descriptive study examined the choices made by patients pre-operatively regarding dentures and/or glasses, the reasons given for the choice, and the relative satisfaction with the choice post-operatively. Of the 213 patients enrolled in this study, 66% were female with an average age of 57 years. Only patients wearing eye glasses or dentures were included. Sixty-nine percent of the patients wearing glasses and 85% wearing dentures chose to wear them to the OR. When asked post-operatively about their satisfaction with their choice, 95% indicated that they were very satisfied with their choice and that it was the best decision they could possibly have made. No glasses or dentures were broken or lost during the study.

Adolescent↗