Biomedical subjects

S Aukee

Publications and source records attributed to S Aukee.

31 records · Page 2Linked to original sources

PubMed1975

Clostridium septicemia following biliary surgery in a gastrectomized patient.

A 75-year-old woman was subjected to biliary surgery 38 years after partial gastrectomy for ulcer. There was a history of gallstones of 10 years duration, pentagastrin-resistant achylia, cholecystolithiasis and choledocholithiasis complicated by stenosis of papilla of vater, cholecystitis and pancreatitis. Peroperative cholangiography and biliary tract surgery were performed. On the third postoperative day heavy jaundice and hemolysis developed, leading to death of the patient. Culture of bile taken at operation revealed strains of Clostridium perfringens and Escherichia coli. Autopsy showed a picture of gas gangraena of the liver and Clostridium septicemia. The role of achylia, blind loop, and biliary obstruction in bile surgery is stressed.

Aged↗

PubMed1975

Bone mineral after partial gastrectomy II.

The bone mineral content estimated by gamma ray attenuation method, serum calcium, phosphorus, alkaline phosphatase, and protein was examined in three types of patients with peptic ulcer. The bone mineral content in ulcer patients before surgery did not differ from that of the control series. In patients subjected to 1/3 gastric resection and Billroth I reconstruction with or without selective vagotomy 3.3-8.5 years previously, and in patients subjected to 2/3 gastric resection with Billroth II reconstruction 15-18 years earlier, the mineral density of bone was found to be lower than in a control series of matched age and sex. The mineral loss developed sooner in women than in men. Low serum calcium values were met most often in patients examined 3.3 to 8.5 years after surgery. The serum alkaline phosphatase level increased after surgery. However, there was no difference in bone mineral density in patient groups with low calcium or high alkaline phosphatase, compared with patients with normal values. In conclusion, gastric resection of 1/3 or 2/3 of the stomach, with or without vagotomy, using gastroduodenostomy or gastroenterostomy as the reconstruction, results in a lowering of bone mineral density. This decrease, however, was not found to have caused symptoms injurious to the health of patients examined in this study.

Adult↗

PubMed1975

Drug absorption in patients with T-tube after cholecystectomy.

The influence of bile flow on the absorption of tetracycline, doxycycline, sulphadimidine and cycloserine was studied in 13 volunteer patients with t-tubes in their main bile ducts after biliary surgery. Their hepatic functions and bile flows were estimated by giving I131 radioiodinated rose-bengal intravenously. About 80% radioactive tracer was recovered from the bile when the t-tube was open, so most of the bile was diverted outside the intestinal tract. Up to 4 hours after administration serum tetracycline levels were lower when the t-tube was open than when the t-tube was closed. In one patient the serum levels were so much reduced that therapeutic serum tetracycline levels could not be achieved. The serum doxycycline levels were fairly high and bile flow did not have any effect on absorption. The 24-hour biliary excretion of doxycycline was only about 15% of the urinary excretion. The absorption of sulphadimidine and cycloserine was not affected by the presence or absence of bile. The bile salts are important surfactants in man, and modify the absorption rate of tetracycline, but not of doxycycline, sulphadimidine and cycloserine. Even in the absence of intact bile flow therapeutic serum tetracycline levels can be expected with the doses currently used.

Adult↗

PubMed1975

Effect of gastric surgery on the gastrointestinal drug absorption in man.

The effect of gastric surgery on the absorption of quinidine, ethambutol, and sulphafurazole was studied in 14 male patients, all serving as their own controls. Antrectomy with gastroduodenostomy (ABI) and selective vagotomy lowered the serum levels of all drugs significantly during the 6-hour test period. Excretion of drugs in 6-hour urine also decreased. Three patients showed practically no absorption up to 2 hours, and even therafter the absorption was lowered. Over one year after operation the urinary excretion of ethambutol, but not of the other drugs, was improved. ABI alone did not modify absorption. Preoperative gastric retention seemed to delay absorption.

Adult↗

PubMed1974