PubMed Health⌕ Search

Biomedical subjects

S B ANDERSEN

Publications and source records attributed to S B ANDERSEN.

16 recordsLinked to original sources
PubMed1964

LYMPHOID ORGANS AND NORMAL GAMMA-GLOBULIN IN THE RAT.

Serum gamma-globulin was determined in adult rats several months after total thymectomy, subtotal splenectomy, or a combination of total thymectomy, subtotal splenectomy, and subtotallymphadenectomy. The thymus apparently is of little importance in the production of normal gamma-globulin, but it may influence the production of albumin because a reduction of serum albumin was only seen in groups where thymectomy was performed. The spleen seems to produce normal gamma-globulin to a greater extent than lymphoid tissue elsewhere in the body.

Alpha-Globulins↗
PubMed1964

GAMMA GLOBULIN TURNOVER IN RABBITS BEFORE AND DURING HYPERIMMUNIZATION.

The turnover of (131)I-labeled gamma globulin has been determined in rabbits before and during (8 weeks later) hyperimmunization with pneumococcic vaccine, which increased the gamma globulin concentration 5 to 10 times. Before immunization fractional turnover rate was an average of 36 per cent of the plasma pool per day, and the rate of catabolism was 133 mg/kg/day. During hyperimmunization fractional turnover rate was an average of 37 per cent per day, and the rate of catabolism was 1160 mg/kg/day. The observation that the fractional turnover rate is independent of the concentration suggests that the rate of breakdown should have the characteristic of a first order process.

Animals↗