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Biomedical subjects

S B Acharya

Publications and source records attributed to S B Acharya.

32 records · Page 2Linked to original sources
PubMed1991

Rat brain endogenous MAO inhibitor (tribulin) activity during carrageenan-induced acute paw inflammation.

The endogenous monoamine oxidase (MAO) inhibitor (tribulin) activity of rat brain was investigated during the course of carrageenan induced acute paw inflammation. The increase in rat brain tribulin activity closely paralleled the time course intensity of the inflammation. The study indicates that, like externally induced stress, internal stress caused by the inflammation induced hyperalgesia can also induce augmented brain tribulin activity. The findings, thus, support the hypothesis that tribulin may function as an endogenous endocoid marker of stress.

Animals↗
PubMed1990

Antiulcerogenic and antiinflammatory studies with shilajit.

In folk medicine, shilajit has been used to treat diverse clinical conditions ranging from peptic ulcer to bone healing. The present study was conducted to evaluate the possible antiulcerogenic and antiinflammatory activities of shilajit obtained from the rocky mountains of Zarlek, Badekshan, Afghanistan. Shilajit increased the carbohydrate/protein ratio and decreased gastric ulcer index, indicating an increased mucus barrier. Shilajit was found to have significant antiinflammatory effect in carrageenan-induced acute pedal oedema, granuloma pouch and adjuvant-induced arthritis in rats. The results of the present study thus substantiate the use of shilajit in peptic ulcer and inflammation.

Animals↗
PubMed1989

Uterine and placental 5-HT profile in different gestational period of albino rats.

Possible role of 5-HT in pregnancy was investigated in albino rats by biological estimation of uterine and placental 5-HT contents in different periods of gestation in normal and drug treated rats. Uterine 5-HT level increased steadily from day-1 of gestation to reach the peak on day-7; thereafter, the level continued to decline throughout the period till day-20 when 5-HT level was lowest. From day-20, a mild secondary rise started and remained persistent even after parturition. The results show that a critical level of 5-HT in early gestational period is necessary for conception. Manipulation of endogenous 5-HT do not influence duration of gestation.

5-Hydroxytryptophan↗
PubMed1983

Platelet products and vascular PGI2 production.

The effects of products synthesized and/or secreted by activated platelets on production of PGI2 by human, rat and rabbit vascular rings were investigated. Of the platelet dense body constituents, 5HT stimulated PGI2 production by vascular tissue of all three species whereas ADP was active only on rat tissue. Of the lipids produced during platelet activation, PAF stimulated PGI2 production by vascular tissue of all three species, Lysophosphatidate was less active than PAF on rabbit and human tissue and inactive in rat tissue, and the TxA2-mimetic, U46619, was inactive on vascular tissue of all three species. It is concluded that there are species variations in the effects of agonists on vascular PGI2 production and that platelet-derived products other than platelet-derived growth factor and beta-thromboglobulin could modulate PGI2 production to regulate platelet activation in vivo.

Adenosine Diphosphate↗