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Biomedical subjects

S B Curri

Publications and source records attributed to S B Curri.

At least 19 recordsLinked to original sources
PubMed1992

Microangiopathy of ethylic polyneuropathy.

The authors have studied, by biopsy of the tip of the big toe, the histologic changes in microvessels of patients affected by ethylic polyneuropathy. Patients affected by diabetes, hypertension, peripheral arterial or venous diseases, or dermatologic diseases or vasculitides were excluded. The mean of daily drinks was 310 +/- 105 g of alcohol, chiefly wine. Important pathologic modifications were noted; complete narrowing of the arteriovenous anastomosis, regressive changes of the Vater-Pacini corpuscles, and dilatation of the small veins and the capillaries. The findings were compared with those of a patient affected by ulcerans and mutilans acropathy of Bureau and Barriere, a typical disease of alcoholics. The same characteristics appeared: profound changes of the structure of the smallest vessels, with sclerosis, extended to the interstitium. In a previous study of the authors, 3 other patients affected by Bureau-Barriere disease showed the same pattern. These alterations can be explained as the effect of alcohol on the microvessels.

Adult↗
PubMed1986

[Microvascular disorders of adipose tissue].

The microcirculation of adipose tissue is poorly understood either because of the absence of histological documents or because they fail to explain pathological conditions. However, disturbances of blood flow and parietal lesions of the microvessels are the basis for these disorders. Although we speak of disturbances of the vascular control mechanisms, these mechanisms are poorly understood and although we speak of arteriovenous short-circuits, the existence of these lesions has not been proven. In fact, classically, the circulation in the dermis and hypodermis is assured by a meshwork of arterioles, venules and capillaries, but biopsies of lateral and anterior regions of the thigh have demonstrated "block devices" in the walls of small arteries and arterioles which are able to regulate the rate of blood flow towards the capillary bed. Following contraction of these devices, the vascular lumen dilates, ensuring free circulation and when they relax, the lumen closes, resulting in decreased or no blood flow. These smooth muscle devices within the arterial wall resemble small cushions in the small arteries and more or less pedunculated polyps in the arterioles, either simple or fissured in the form of an elephant's trunk with a safety valve effect, arranged either in a single column or in two columns face to face. This provides evidence for the particularly disturbed vasculo-tissue inter-relations observed in venous insufficiency.(ABSTRACT TRUNCATED AT 250 WORDS)

Adipose Tissue↗
PubMed1977

[Anthocyanosides and the walls of the microvessels: further aspects of the mechanism of action of their protective effect in syndromes due to abnormal capillary fragility].

On the basis of previous biochemical observations, which have demonstrated the formation of complexes between anthocyanosides and some phospholipids, the AA. investigate the modifications induced by local and general administration of anthocyanosides 1) on the foreign body granuloma and 2) on the composition of the protein fractions in the exudate from the capillaries of the granulation tissue, growing on post-thromboflebitic or varicose leg ulcerations. The biochemical and histochemical data may show that the anthocyanosides protect the altered capillary walls with a double mechanism: a) increasing the endothelium barrier-effect through a stabilisation of the membrane phospholipids and b) increasing the biosynthetic processes of the acid mucopolysaccharides of the connective ground substance, by restoring the altered mucopolysaccharidic pericapillary sheat. This last effect may explain the marked increase of new-formed capillaries and collagen fibrils induced by the anthocyanosides.

Adult↗
PubMed1977

The fine structure of human digital arterio-venous anastomoses (Hoyer-Grosser's organs).

Hoyer-Grosser's organs were studied in human digital biopsies. The fine structure of both the supplying arteries and collecting veins was found to be inconspicuous. Endothelial cells in the AV canals form a continuous layer. They are characterized by their rich content of specific organelles (Weibel-Palade bodies), especially in the venous segments. The epitheloid zone is composed of a variety of ramified smooth muscle cells (RSM). These appear either dense, when well provided with bundles of myofilaments, or clear, when including only a few myofilaments. The nuclei of dense RSM show condensed chromatin, while those of clear RSM are larger with loose chromatin texture. In addition, all transitional forms occur. Cell organelles are rarely seen within all types of RSM. The cytoplasmic processes reach other as well as endothelial cells. The preservation of our material did not allow observation of specialized membrane contacts in these zones. All RSM are invested with a regular basal lamina and well provided with surface vesicles. Profiles of free basal lamina material and faint collagen (argyrophil) fibers are seen in the wide intercellular spaces. RSM poor in myofilaments are interpreted to represent "epitheloid cells" of light microscopy. Their number constantly decreases from the arterial segment of the AV canal to the venous segment. Here the cytoplasmic processes of RSM become less pronounced and the wall of the anastomotic segment continuously changes to that of the collecting vein. Dense RSM rich in myofilaments are compared with pacemaker cells found inthe ureter. Both internal and external elastic membranes are absent in AV canals. A dense network of unmyelinated nerve fibers is found in the adventitial layer of the AV canal, especially in its arterial segment. The axons branch out from small dermal nerves which also contain two or three myelinated axons. The myelin sheaths terminate where the axons reach the adventitia of the AV canals. Axon varicosities filled with mitochondria are thought to be terminals of myelinated axons and are interpreted as receptory. Axon varicosities with synaptic-type vesicles are assumed to be terminals of sympathetic and para sympathetic fibers. All axon profiles are confined to the adventitial layer of the anastomotic segment.

Arteriovenous Anastomosis↗
PubMed1975

Plasma and red blood cell phospholipids in chronic liver diseases.

The total phospholipid content and the individual phospholipids, phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine and phosphatidylserine, and sphingomyelin were determined in the plasma and red blood cells of 58 patients with chronic liver disease and 12 control subjects by quantitative extraction and thin-layer chromatography. The total phospholipids were significantly reduced in both the plasma and red blood cells of the patients with liver disease. For the individual phospholipids, plasma sphingomyelin was significantly decreased, in the red blood cells there was an increase in lysophosphatidylcholine and a decrease in phosphatidylethanolamine and phosphatidylserine compared to the control subjects. It is suggested that in chronic liver disease the red blood cell lipid disturbances follow more closely those of the hepatocyte than those in plasma.

Chromatography, Thin Layer↗
PubMed1975

[Total and fractionized plasma phospholipids in chronic liver diseases].

The literature data relating to the importance of the liver in fat metabolism, and the behaviour of plasma and red cell phospholipids, cholesterol, triglycerides, fatty acids and lipoproteins in acute and chronic liver disease is reviewed. The results of an investigation of the diagnostic and prognostic significance of total and single plasma phospholipid levels in a series of 70 cases (5 chronic aggressive hepatitis, 12 compensated cirrhosis, 41 uncompensated cirrhosis, and 12 controls) are presented. Quantitative assessment by means of thin-layer chromatography showed four features of marked prognostic interest: a) a significant decrease in total phospholipids; b) increased phosphatidyl choline; c) increased phosphatidyl ethanolamine; d) decreased sphingomyelin. In discussing the results, stress is laid on the fact that this method offers a sufficient close evaluation of the clinical picture with respect to both the evolution of cirrogenic liver diseases and the effectiveness of their treatment. It also enables an assessment to be made of liver cell mitochondria function.

Adult↗