Biomedical subjects

S B Grimm

Publications and source records attributed to S B Grimm.

3 recordsLinked to original sources

PubMed1996

Excimer laser in situ keratomileusis under a corneal flap for myopia of 2 to 20 diopters.

PURPOSE: We studied the efficacy and safety of a recent technique of keratomileusis for myopia, excimer laser in situ keratomileusis. METHODS: We studied retrospectively 88 eyes of 63 patients who received excimer laser in situ keratomileusis with the Chiron Automated Corneal Shaper and the Summit OmniMed laser under a hinged corneal flap without sutures. RESULTS: Mean follow-up was 5.2 months. Mean spherical equivalent of the manifest refraction before surgery was -8.24 diopters (range, -2.00 to -20.00 diopters). Mean spherical equivalent refraction after surgery was +0.22 +/- 1.42 diopters. Of 40 eyes with a baseline refraction from -2.00 to -6.00 diopters, 25 eyes (63%) had refraction within +/- 0.50 diopter of emmetropia, and 37 eyes (93%) had refraction within +/- 1.00 diopter. In eyes with baseline refraction of -6.12 to -12.00 diopters, postoperative refraction was within +/- 1.00 diopter in 19 (65%) of 29 eyes. In eyes with baseline refraction of -12.10 to -20.00 diopters, postoperative refraction was +/- 1.00 diopter in eight (43%) of 19 eyes. Overall, 64 (72.8%) of 88 eyes had a refraction within +/- 1.00 diopter after surgery. Between three weeks and five months after surgery the change in the mean spherical equivalent refraction was -0.61 diopter in the myopic direction. Uncorrected visual acuity after surgery was 20/20 or better in 31 eyes (36%) and 20/40 or better in 61 eyes (71%). Three eyes (3.6%) lost two lines or more of spectacle-corrected visual acuity, two from progressive myopic maculopathy and one from irregular astigmatism. No eyes had vision-threatening complications. CONCLUSION: Excimer laser in situ keratomileusis under a corneal flap can be an effective method of reducing myopia between -2.00 and -20.00 diopters, with minimal complications. Current surgical algorithms need modification to improve predictability of outcome. Stability of refraction after surgery requires further study.

Adolescent↗

PubMed1995

Posterior amorphous corneal dysgenesis.

PURPOSE: Posterior amorphous corneal dysgenesis is a rare disorder previously described in only four families. We expanded the spectrum of findings and updated the classification by adding seven additional cases. METHODS: Three index cases were identified during ophthalmic examination at the El Maghraby Eye Hospital and Eye Center in Jeddah, Saudi Arabia. We examined all available members of three families of different ethnic origin (Saudi Arabian, Egyptian, and Indian) and found seven cases of affected patients. Videokeratography and slit-lamp photomicrography were done in selected cases. RESULTS: In all seven cases, the corneas showed bilateral, diffuse, sheetlike opacities in the posterior stroma, with extension to the corneoscleral limbus, and corneal thinning in the more severely affected eyes. The clinical findings included variations in corneal thickness noted by slit-lamp microscopy and ultrasonic pachymetry, cornea plana, marked corneal astigmatism, and progressive ectasia of the cornea. CONCLUSIONS: Posterior amorphous corneal dysgenesis is characterized by gray sheetlike opacities in the posterior stroma. It occurs in many ethnic groups and exhibits a varied spectrum of clinical findings, including iridocorneal adhesions and cornea plana. We think the anatomic abnormalities of the cornea warrant classification as a corneal dysgenesis rather than as a dystrophy. Longitudinal studies of individual eyes and investigation of associated abnormalities in other pedigrees may help resolve this distinction.

Adult↗

PubMed1995

Excimer laser in-situ keratomileusis (LASIK) under a corneal flap for myopia of 2 to 20 D.

BACKGROUND: We report the results of a recent technique of keratomileusis for myopia: excimer laser in-situ keratomileusis (LASIK). METHODS: We studied retrospectively 88 eyes of 63 patients that received LASIK with the Chiron Automated Corneal Shaper and the Summit OmniMed excimer laser under a hinged corneal flap without sutures. RESULTS: Mean follow-up was 5.2 months. Mean spherical equivalent of the manifest refraction before surgery was -8.24 diopters (D)(range -2.00 to -20.00 D). Mean spherical equivalent refraction after surgery was +0.22 D (SD, 1.42 D). Of 40 eyes with a baseline refraction from -2.00 to -6.00 D, 25 (63%) had a refraction within +/- 0.50 D and 37 eyes (93%) within +/-1.00 D. In 29 eyes with baseline refraction of -6.12 to -12.00 D, postoperative refraction was within +/-1.00 D in 19 (65%). In 19 eyes with baseline refraction of -12.10 to -20.00 D postoperative refraction was +/-1.00 D in 8 (43%). Overall, 64 of 88 eyes (72.8%) had a refraction within +/-1.00 D after surgery. Between three weeks and five months after surgery the change in the mean spherical equivalent refraction was -0.61 D in the myopic direction. Uncorrected visual acuity after surgery was 20/20 or better in 31 eyes (36%) and 20/40 or better in 61 eyes (71%). Three eyes (3.6%) lost two lines or more of spectacle corrected visual acuity, two from progressive myopic maculopathy and one from irregular astigmatism. No eyes had vision threatening complications. CONCLUSION: Excimer laser in-situ keratomileusis (LASIK) under a corneal flap can be an effective method of reducing myopia between -2.00 to -20.00 D, with minimal complications. Current surgical algorithms need modification to improve predictability. Stability of refraction after surgery requires further study.

Adolescent↗