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Biomedical subjects

S B Moon

Publications and source records attributed to S B Moon.

5 recordsLinked to original sources
PubMed2001

A purified inactivated Japanese encephalitis virus vaccine made in Vero cells.

A second generation, purified, inactivated vaccine (PIV) against Japanese encephalitis (JE) virus was produced and tested in mice where it was found to be highly immunogenic and protective. The JE-PIV was made from an attenuated strain of JE virus propagated in certified Vero cells, purified, and inactivated with formalin. Its manufacture followed current GMP guidelines for the production of biologicals. The manufacturing process was efficient in generating a high yield of virus, essentially free of contaminating host cell proteins and nucleic acids. The PIV was formulated with aluminum hydroxide and administered to mice by subcutaneous inoculation. Vaccinated animals developed high-titered JE virus neutralizing antibodies in a dose dependent fashion after two injections. The vaccine protected mice against morbidity and mortality after challenge with live, virulent, JE virus. Compared with the existing licensed mouse brain-derived vaccine, JE-Vax, the Vero cell-derived JE-PIV was more immunogenic and as effective as preventing encephalitis in mice. The JE-PIV is currently being tested for safety and immunogenicity in volunteers.

Animals↗
PubMed1987

Joint factor analysis of the K-ABC and McCarthy Scales.

A joint-factor analysis was conducted using three major scales of the McCarthy Scales of Children's Abilities and eight Kaufman-ABC sub-tests as variables. Subjects were 90 children ages 4 to 8 1/2 yr. The screen test produced three significant factors, each interpretable from the Kaufman-ABC model. McCarthy Verbal scale was closely associated with the Achievement/Verbal factor; McCarthy Perceptual performance scale loaded highly on the Simultaneous Processing dimension; and McCarthy Quantitative was associated with all three factors. These results provide useful guidelines for interpreting a child's performance on each Index of the McCarthy scales in terms of the mental processing approach used to solve the task. However, the psychometric results must be coordinated with the examiner's clinical observations of the child's problem-solving strategies during administration of the McCarthy scales to understand more completely the processing demands of the Verbal, Perceptual performance, and Quantitative Scales.

Achievement↗
PubMed1981

Justification: the initial step in the expansion of a pharmacy service.

The tactics used by a director of pharmacy to get a new program approved are discussed. These include the use of justifications, both oral and written, the development of interpersonal relationship, the formation of coalitions with other department heads, timing, and various types of analysis. Some of the dangers of a written justification are emphasized. Among the precautions to be borne in mind are underestimating the abilities of the administrator, being too optimistic in one's predictions, being too conservative when planning the program, and not having a series of proposals for pharmacy expansion available at all times.

Communication↗