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Biomedical subjects

S B Pershin

Publications and source records attributed to S B Pershin.

At least 19 recordsLinked to original sources
PubMed1989

[The immunomodulating action of microwaves in the induction of an immune response to Vi antigen].

In this work the possibility of using microwaves for immunomodulation in the immunization of animals with thymus-independent antigen was studied. The projection zones of the thymus and adrenal glands of the test animals were subjected to the action of decimeter, or ultrahigh frequency (UHF), waves, while the corresponding zones of the control animals were subjected to imitation UHF irradiation. Vi-antigen was shown to be a thymus-independent antigen for rabbits (according to the results of the evaluation of the functional state of thymocytes, as manifested by the adsorption of acridine orange by the chromatin of thymocyte nuclei and by the content of RNA and DNA in the thymus). The action of UHF waves on the projection zone of the thymus was accompanied by a decrease in the glucocorticoid activity of the adrenal cortex, observed simultaneously with a pronounced immunostimulating effect. The UHF irradiation of the zone of the adrenal glands was accompanied by immunosuppression in combination with enhanced glucocorticoid activity of the adrenal cortex.

Adrenal Cortex Hormones↗
PubMed1986

[Immunobiological effect of bitemporal exposure of rabbits to microwaves].

The immunobiological effect of electromagnetic microwaves applied to parietotemporal area was studied. It was shown that the exposure of parietotemporal area to microwaves produced an immunodepressive effect manifested in the decreased number of natural (background) antibody-forming cells. The exposure of parietotemporal area to microwaves was accompanied by glucocorticoid function stimulation in the adrenal cortex and thyroid function depression.

Adrenal Cortex↗
PubMed1979

[Depression and stimulation of immunologic memory by typhoid lipopolysaccharide and polysaccharide].

The effect of typhoid lipopolysaccharide (LPS) and polysaccharide (PS) on immunological memory in the system of IgM and IgG synthesis and rosette-forming cells was studied. When introduced into animals previously immunized with SRBC, PS stimulated, under certain conditions, immunological memory in the system of IgM synthesis and rosette-forming cells, while the injection of LPS induced only an insignificant stimulation of immunological memory. No stimulation in the system of IgG synthesis was observed after the injection of both LPS and PS. The suppression of immunological memory was noted in the animals receiving LPS as well as in those receiving PS the immunosuppressing effect produced by LPS was more pronounced.

Animals↗
PubMed1979

[Effect of a typhoid lipopolysaccharide on the primary and secondary immunological response to ram erythrocytes].

The effect of typhoid bacterial lipopolysaccharide (LPS) on the primary and secondary response to sheep red blood cells was studied. LPS, injected simultaneously with the antigen, stimulated the synthesis of IgM and IgG, as well as the production of rosette-forming cells. When injected on days 2 and 3 after the secondary immunization, LPS induced the maximum stimulation of IgM, IgG and rosette-forming cells, while the injection of LPS prior to immunization induced immunosuppression which particularly affected IgG and rosette-forming cells.

Animals↗
PubMed1977

[Effect of inhibitors of nucleic synthesis on induction of the secondary immunologic response in vitro].

The authors studied the influence of the DNA and RNA inhibitors on the formation of antibody-forming cell populations in induction of a secondary immunological response in vitro. Low concentrations of cytosine-arabinoside, the DNA synthesis inhibitor, increased the count of indirect hemolysin-forming and rosette-forming cells; its high concentrations depressed the secondary immunological response induction in the direct hemolysin-forming cell system more intensively than in the indirect cell system. Actinomycin D depressed the stimulation of secondary immunological response in vitro both in the systems of direct and indirect hemolysin-forming, and of rosette-forming cells.

Animals↗
PubMed1977

[Induction of the immunologic response in vitro].

Immunological response (primary and secondary) was induced in a suspension of mouse splenic cells on nutrient media containing embryonic calf serum or serum against the erythrocytes of an animal--the lymphoid cells donor. The in vitro immunological response was accompanied by a specific increase in a number of the hemolysin-forming and rosette-forming cells. The optimal for induction of the immunological response in vitro was a dose of 10(7) erythrocytes per 1 ml of the culture. It was shown experimentally that antierythrocytic serum could be used instead of the embryonic calf serum to induce the immunological response in vitro. An increase in the count of rosette-forming cells and no increase of the hemolysin-forming cell count was observed on the nutrient media without 2-mercaptoethanol.

Animals↗
PubMedDate not supplied

[The immunological and hormonal effects of combined exposure to a bitemporal ultrahigh-frequency electrical field and to decimeter waves at different sites].

Bitemporal UHF electric field is shown to enhance glucocorticoid adrenal function unlike inhibition of the thyroid function suppressing a primary immune response (PIR) in the productive phase. The combined exposure to bitemporal UHF electric field and decimeter waves of the adrenals doubles glucocorticoid synthesis abolishing the inhibitory action of the UHF therapy on thyroid function resultant in much more suppressed PIR. Both modalities inhibit thymic production. Decimeter waves alone are less effective. The exposure of the thyroid to decimeter waves initiated PIR by 2.5-fold activation of medullar lymphocytes and by a 80% increase in the thymic function. No response was achieved in combined action on the thyroid of the electric field and decimeter waves.

Adrenal Glands↗
PubMedDate not supplied

[The combined action of an ultrahigh-frequency electrical field bitemporally and decimeter waves on the thymus area in the combined therapy of rheumatoid arthritis patients].

The thymus of rheumatoid arthritis (RA) patients was exposed to combined action of bitemporal UHF electric field and decimeter waves to study immunomodulating effect of the combination. Biochemical, immunological and endocrinological findings during the patients follow-up gave evidence for conclusion on activation of the hypothalamic-hypophyseal-thymic axis. A response was achieved in RA seronegative variant with concomitant synovitis. This may be due to genetic factors.

Arthritis, Rheumatoid↗
PubMedDate not supplied

[The functional changes in the hypothalamus under the influence of an ultrahigh-frequency electrical field].

The experimental study was performed to clarify the advance of the biological effect of UHF bitemporal therapy. Realization of the effect proceeds at the expense of alterations in the patency of neuromediator and endogenic opioid systems of the brain. In addition, the study covered modulations of peripheral endocrine glands by hypophysis, glucocorticoids and catecholamines by the adrenals, proliferation of the lymphoid tissue, functional activity of humoral immunity.

Animals↗
PubMedDate not supplied

[The immunomodulating effect of microwaves and of an ultrahigh-frequency electrical field in patients with systemic lupus erythematosus].

Bitemporal exposure of the adrenals to UHF electric field and decimeter waves was studied as a component of combined therapy for stage I-II chronic SLE. The best therapeutic response was achieved at bitemporal employment of UHF electric field directed to the system hypothalamus-hypophysis. This may be due to enhanced glucocorticoid activity of the adrenals and immunomodulating effect: a rise in the T-lymphocytes number, humoral immunity suppression. Antiinflammatory action was seen from a positive trend in clinical symptoms. Less therapeutic response to the direct stimulation of the adrenals with decimeter waves stems from the deficient function of the latter consequent to long-term corticosteroid therapy.

Adrenal Glands↗
PubMedDate not supplied

[The immune and hormonal effects of the local action of microwaves of different intensities].

The trend in immune and hormonal parameters in thyroid, adrenal and transcerebral exposure to microwaves with intensity of 120, 240 and 480 mW/cm2 was studied in rabbits. The thyroid exposure to 120 and 240 mW/cm2 microwaves lead to immunostimulation, while adrenal and transcerebral one induced immunosuppression. The exposure to 240 mW/cm2 and 480 mW/cm2 microwaves resulted in damage to the tissues in 56 and 100% of the animals, respectively. The latter irradiation appeared lethal for 25% of the rabbits. 120 mW/cm2 MV proved safe as there were no signs of edema and necrosis seen with more intensive microwaves. The authors suggest to employ microwaves of 120 mW/cm2 intensity for endocrine glands irradiation to produce an immunomodulating effect.

Adrenal Glands↗
PubMedDate not supplied

[The dynamics of the immunobiological effects in transcerebral microwave exposures].

The trend in immunobiological responses to transcerebral action of decimeter microwaves was studied in intact rabbits. Transcerebral microwaves (120 mW/cm2) can alter functional activity of certain links of endocrine system due to possible activation of hypothalamus and hypophysis exposed to microwave electromagnetic field. Such exposure given in courses at early stages leads to an increase in the number of antibody-forming cells in the spleen, whereas total number of splenocytes is on the decrease.

Animals↗