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Biomedical subjects

S B Siwach

Publications and source records attributed to S B Siwach.

At least 37 records · Page 2Linked to original sources
PubMed1993

Comparative evaluation of dopamine infusion & treadmill exercise tests in the diagnosis of coronary artery disease.

Dopamine infusion test (DIT) was compared with treadmill exercise test (TMT) in 20 patients of chronic stable angina (TMT +ve) for inducing reversible myocardial ischaemia so as to assess its efficacy as an alternative to TMT in patients who cannot perform exercise test due to certain non-cardiac diseases. DIT was positive in 15 of the 20 patients studied; five patients in whom DIT was negative had late onset, early offset changes in TMT. Haemodynamically the increase in heart rate (HR) was less but rise in systolic blood pressure (SBP) was more with dopamine infusion in comparison to the corresponding stage of TMT. However, evidence of myocardial ischaemia (ST segment depression) appeared at a lower rate pressure product (RPP) with dopamine infusion compared to exercise test. The test was tolerated well, in higher doses (stages III & IV) side effects like ventricular ectopic beats, palpitation and angina not warranting stoppage of test, were seen in some patients. Dopamine infusion is a good chemical stress test, and can be used as an alternative to TMT especially in situations where the latter cannot be performed. The test is simple, cost effective, non-invasive and well tolerated.

Angina Pectoris↗
PubMed1993

Effect of atenolol and labetalol on serum lipids.

Adverse alterations in lipid profile suggesting higher atherogenicity were observed following 12 weeks treatment with atenolol in patients of hypertension. No significant alterations in lipid profile were observed with labetalol therapy.

Atenolol↗
PubMed1992

Multichamber intracardiac thrombi in a patient without any predisposing cardiac or non-cardiac disease.

A patient who developed multichamber (left ventricle, right ventricle, right atrium) intracardiac thrombi without having any predisposing cardiac or non-cardiac disease is discussed. The thrombi were diagnosed echocardiographically and confirmed histopathologically. The occurrence of multichamber mural thrombi without any predisposing disease is extremely rare. Risk factors for their development have been reviewed.

Blood Coagulation Tests↗
PubMed1992

Saddle embolism of aorta.

Aortic saddle embolus is a rare but serious form of arterial embolisation in patients with myocardial infarction. Four patients with aortic saddle embolism with peripheral propagation of the clott are reported. Two patients had suffered an attack of acute anterior myocardial infarction (one and four weeks respectively) prior to the embolic episode. One patient had a transmural myocardial infarct five years ago, and the 4th patient had dilated cardiomyopathy. The onset was sudden, marked by pain, parasthesias, pallor, pulselessness in three patients, and gradual in one. Two of the three patients (both females) in whom clott migration occured in only one limb developed below-knee gangrene of the affected side. In one patient (a young male) clott migration occurred in both popliteal arteries and the limbs were spared from developing gangrene although he continues to have leg angina. One patient presented with intermittent calf claudication only. All our patients reported late due to which none could be subjected to embolectomy.

Adult↗
PubMed1991

Indirect assessment of acute effects of ethyl alcohol on coronary circulation in patients with chronic stable angina.

Acute effects of ethyl alcohol on left ventricular performance, haemodynamic and electrocardiographic response to treadmill exercise test were studied in 20 patients with chronic stable angina. Following ingestion of 80 ml of whisky (43% ethyl alcohol by volume) the mean heart rate and rate-pressure product decreased significantly at the end of each stage of exercise compared to corresponding prealcohol values. There were also significant derangements in systolic time intervals parameters in the form of decrease in left ventricular ejection time I and increase in pre-ejection phase I and pre-ejection phase/left ventricular ejection time ratio after alcohol intake indicating a depression in left ventricular performance. However, following alcohol intake the mean exercise time (6.5 +/- 3.8 minutes) until onset of ischaemic ST segment depression decreased significantly (P less than 0.01) compared to the corresponding prealcohol exercise time (8.6 +/- 3.5 minutes). Interestingly, the mean rate-pressure product (an indicator of myocardial oxygen demand) at the onset of ischaemic ST segment depression was significantly less (P less than 0.01) when exercise test was done after alcohol intake compared to the corresponding pre-alcohol value. The data indicated that despite significant decrease in myocardial oxygen demand produced by alcohol intake, ST T changes developed early and at a lower rate-pressure product, indicating decreased blood flow to the ischaemic zones of the myocardium. This may be explained by the coronary steal effect produced by alcohol.

Adult↗
PubMed1990

Myositis ossificans in tetanus. A rare complication.

Myositis ossificans developing as a complication of tetanus is very rare. There are only nine cases reported so far. We report here a case of a young female who developed myositis ossificans in both the elbow joints as a complication of severe tetanus.

Adult↗
PubMed1990

Estimation of 24 hour protein excretion from single random urine specimen.

The product of protein/creatinine ratio (in a random urine specimen) and estimated daily urinary creatinine excretion were evaluated as a function of 24 h urinary protein excretion in 40 patients with pathology proteinuria having varying grades of renal function. An excellent correlation was found between the results obtained by this method and those from the standard 24 h urine collection method in healthy controls (r = 0.99) and in patients with normal (r = 0.88) or mild to moderately impaired renal function (r = 0.99). However, this method did not give a good measure of quantitative proteinuria in patients with advanced renal failure (r = 0.56), possibly due to decreased urinary excretion of creatinine in patients with advanced renal failure as compared to the estimated value. The product of protein/creatinine ratio and estimated daily urinary creatinine excretion thus gave a quick and alternate reliable method of estimating 24 h proteinuria in patients having normal or mild to moderately impaired renal function. However, this method is not suitable for patients with advanced renal failure.

Adolescent↗
PubMed1989

DC cardioversion and coronary artery spasm.

Marked ST segment elevation which occurred following DC shock given for conversion of lone atrial fibrillation in a 55 years old male is reported. This was possibly coronary artery spasm induced by direct current and adds one more complication to the many already described.

Atrial Fibrillation↗
PubMed1984

Epidemiology of hypertension in a north Indian population. Based on rural-urban community surveys.

The epidemiology of hypertension was studied on the basis of total community surveys in defined urban (mostly non-agricultural) and rural (agricultural) populations of Haryana, using WHO criteria. A total of 4,068 subjects, comprising 95% of the eligible populations, were examined. Hypertension was found to be almost twice as common in the urban (64.3/1,000) as in the rural group (35.7/1,000). The prevalence of hypertension as well as the mean pressures were greater in men than in women in the 3rd and 4th decades, after which the pattern was reversed in all the subsequent age groups. The regression lines intersected at approximately 45 years of age. However, there was no appreciable sex difference in either group in the overall prevalence of hypertension. The mean systolic and diastolic pressures rose significantly with increasing age. These were generally lower in rural than in urban subjects and there was a difference of almost one decade group. Only one out of every four hypertensives detected during the survey was aware of his disease, and even among these three-fourths were either untreated or inadequately controlled. The lower prevalence of hypertension was associated with lesser mean pressures in the rural community, and both these observations are ascribed to a much larger proportion of rural people (compared to city dwellers) being thinner in size, engaging in hard physical activity, and belonging to a lower socio-economic group. The data have also been compared with other studies from India and abroad and the possible reasons for the observed differences discussed.

Adult↗
PubMed1983

Cardiovascular complications of enteric fever.

A case of a young female having salmonella typhi infection with cardiovascular complications in the form of myocarditis and femoral artery occlusion is reported. The relevant literature on the subject is reviewed, and possible mechanisms discussed.

Adult↗