Biomedical subjects
Publications and source records attributed to S B Taylor.
After consuming either an alcoholic or nonalcoholic beverage, 48 subjects viewed a humorous film. Frequency of responsive laughter and subjective amusement was significantly greater in the alcohol group.
This article documents the reduced caloric requirements for a spastic, immobile, cerebral palsy patient. We report an 11-year-old immobile, spastic, quadriparetic patient who remained obese despite receiving less than one half of the recommended basal caloric requirements for age. Basal metabolic rate was determined by indirect calorimetry using a Sensor Medics 2900 instrument. Standard reference sources indicate that an able-bodied 11-year-old child of comparable height requires 1,493 kcal/d for support of basal metabolic functions. Our patient was followed for 8 weeks on reduced calories and assessed for adequacy of diet by nitrogen balance studies and other appropriate parameters. Our data suggest that a subset of severely impaired children with cerebral palsy may require much less in total kilocalories per day for nutritional support than previous studies would indicate.
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In normal adults, emotional expressions tend to be more intense on the left side of the face, while in preschool-age children, no significant bias in facial asymmetry has been found. We examined facial asymmetries during smiling and distress in 59 infants studied longitudinally at 6.5, 10 and 13.5 months of age. In these infants, asymmetric expressions showed a bias toward greater intensity on the right side of the face. The study of infant facial expression may provide clues to the maturation of the cortical control of emotional responses.
Two patients demonstrating a bifid origin of the left vertebral artery are described. The embryologic origin of this anomaly is reviewed together with diagnostic and therapeutic implications, emphasizing the importance of knowledge and recognition of the anomaly. It is suggested that this anomaly is not as rare as previously thought.
This pilot study in limited-stage small-cell carcinoma of the lung using concurrent cisplatin (Platinol) and etoposide (VePesid) chemotherapy with radiotherapy has yielded a high complete response rate in 23 of 40 patients evaluable for response. Five of these responders have survived greater than 2 years off all therapy with a stable, high performance status. Median survival of all patients is 18 months. Toxicity has been acceptable, the most common being neutropenia. Radiation toxicities include 17 of 40 patients experiencing mild to moderate esophagitis, with one severe toxicity; and three of 40 patients developing mild to moderate radiation pneumonitis. The high complete remission observed with this program and the long tumor-free interval seen off maintenance therapy deserve further exploration. Toxicities appear only moderately greater than with other programs currently utilized.
An analysis of admission and follow-up CT examinations of the brains of 17 children who had nearly drowned (15 of whom were comatose and two of whom were conscious on admission) indicated that a normal initial CT scan is common in the majority of comatose patients, a severe neurologic outcome may develop in spite of a normal initial CT examination, and abnormal initial or follow-up CT findings indicate the strong but not inevitable probability of a severe neurologic outcome. We conclude that when there is no head trauma, an initial CT examination is not necessary. Prediction of the clinical outcome cannot be made on the basis of the initial CT findings.
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