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Biomedical subjects

S B Wang

Publications and source records attributed to S B Wang.

17 recordsLinked to original sources
PubMed1995

[Rational evaluation of different lymph node dissection].

To evaluate the effect and indication of different lymph node dissection (D1+, D2, D3), we performed radical operations for 371 cases of gastric cancer. The results showed that D1+ or D1 lymph node dissection was enough for gastric cancer of Ia stage, D2 was suitable for Ib stage. For localized or massive type gastric cancer of II + III stage, D3, D2 dissection was better than D1+ dissection. For the gastric cancer of the same type in IV stage, the 5-year survival rate after D3 + D2 dissection was 42.9%, but for the gastric cancer of infiltrative type or diffused growth pattern in II + III stage, the effect was not significantly increased even after the D3, D2 dissection. For the gastric cancer of this type in IV stage, the effect was not improved after the extended lymph node dissection. Extended dissection needn't be performed if there was no lymph node metastasis. D3, D2 dissection was better if there was little lymph node metastasis or the metastasis was limited to 1st group. For those metastasized to 2nd group or the quantity was more, D3 was better than D2, D1+. The effect of D3, D2 dissection was not significantly improved in the extensive metastasis case (more than 10 or to the 3rd group).

Adult↗
PubMed1994

[Effects of different lymph node clearances on long-term survival in patients with gastric carcinoma].

From 1980 to 1987, radical gastrectomy plus R2 or R3 lymph node clearance was performed in 309 cases of gastric carcinoma of which 179 were with R2 and 130 with R3. The 1, 3, 5 years survival rate of R3 was statistically higher than that of R2. The 5 years survival rate of R2 was nearly the same as R3 in patients at stage I (I a, I b) and borrmann type I and II, While R3 yields better results than R2 at stage II and III a, it was even 25.5% higher by R3 than by R2 at II b and IV. R3 still benefits patients at stage II with serosa infiltration, R3 should also be performed in advanced cases with poorly biologic behavior, such as diffuse growth pattern; undifferentiated cancer and lymphatic cancerous embosis. The recovery time, complications and mortalities of patients with R2 or R3 were mainly related to the model of gastrectomy not to the extent of lymph node clearance.

Adult↗
PubMed1993

Classification of deep burn injuries--analyses of 117 cases.

A new system of classification, index of deep burn injuries (IDBI), was proposed in this paper. Using this system, we investigated 304 burn sites in 117 cases, of which 94.1% were repaired with the GCM with a satisfactory result. The IDBI of the 304 burn sites is in direct proportion to the severity and extent of burn injury and inverse ratio to the results. Analyses performed in this group suggested that the IDBI has many significances, which include: 1, making a correct diagnosis; 2, providing decided repair indications; 3, indicating the prognosis; 4, providing a reliable method for further investigation in the burn field. The standard of IV degree burn is equal to or more than 2 of IDBI.

Adolescent↗
PubMed1992

[DNA content and cell cycle in irradiated HeLa S3 cells].

DNA content and cell cycle of irradiated HeLa S3 cells in the exponential phase was measured by image analysis and flow cytometric analysis. The HeLa S3 cell phases had undergone remarkable changes after irradiation. There was a dose dependent radiation effect. As the radiation dose increased, the number of G0 + G1 and S phase cells were reduced and G2 + M phase delay occurred. The number of G2 + M phase in HeLa S3 cells after 6-8 Gy was increased from 22% to 52%-61%. Meanwhile, the DNA content of HeLa S3 cells was increased from 6.72 to 9.08-10.0 Au, the results of these two assays were compatible. Most of the delay of G2 + M phase appeared 24 hours after irradiation. The concentration of HeLa S3 cells used varied from 32 x 10(4)/ml to 147 x 10(4)/ml in the experiments. No relationship was observed in the changes of phase and cell concentrations.

Cell Cycle↗
PubMed1991

Inhibition of mitochondrial respiratory function by an organic solvent extractable component from an extract of burn eschar.

Saline extracts of burn eschar (CEBE) and normal skin (CENS) caused inhibition to mitochondrial respiration and inner membrane function. Ethyl acetate extracts from CEBE (D1) and CENS (D'1) caused depression of the Respiratory Control Ratio, (RCR), an inhibition of respiration rate in state 3 and stimulation to state 4 respiration. Excellent linear correlations exist between the degree of inhibition to state 3, rate of stimulation to state 4 respiration and the logarithm of doses of D1 and D'1. The effective dose ranges (0.75-0.25 mg/ml for D1 and 4-1 mg/ml for D'1) differ by one order of magnitude. The activity of NADH dehydrogenase and succinate dehydrogenase of mitochondria after incubation with the highest toxic dose of D1 or D'1 remained normal. Dinitrophenol (DNP)-stimulated respiration was moderately inhibited by D1 and D'1. No change of oligomycin-sensitive ATPase activity was demonstrated. Exogenous malondialdehyde (MDA) did not show any inhibitory effect. Preliminary studies show that D1 contains a family of free fatty acids (FFA). Incubation of normal mitochondria with D1 increased the content of saturated FFA and a decrease of unsaturated FFA. The role of other peroxidative products is under investigation.

Adenosine Triphosphatases↗
PubMed1989

Imaging diagnostic value of myxoma in cardiac chamber. An analysis of 23 cases.

Twenty-three patients with myxoma in the cardiac chamber were analysed from their clinical manifestations and imaging diagnoses. All the patients were confirmed pathologically and 22 of them were further confirmed by operation. In this series, 18 patients had the tumors in the left atria, 3 in the right atria, and 2 in the right ventricles. Diagnosing myxoma by CT and two-dimensional echocardiography was evaluated. The results suggest that to diagnose myxoma in the cardiac chamber, CT is as effective as sonography because it can display clear image, precise location and mobility of the tumor with the flowing blood stream in the cardiac chamber, and provide reliable indications for surgery.

Adolescent↗
PubMed1989

[Thermotolerance of tumors MA737 and LA795 of mice].

The effects of splitted heating of tumor, alone or in combination with local radiation, were studied on mouse mammary cancer MA737 in JB 2 mice and lung cancer LA795 in 739 mice. Hyperthermia was done by immersing the tumor-bearing foot into a water bath at 44 +/- 0.2 degrees C. When combined with radiation, 8 Mev beta irradiation from a linear accelerator was given. The response was assessed by tumor growth retardation calculated according to a special computer program. A priming dose of 5 to 6-minute exposure to 44 degrees C was followed, after various time intervals (1, 4, 5, 24 hr), by a longer exposure. Thermotolerance was induced in these two animal tumor models. Tolerance to heat, however, did not affect the combined effect of hyperthermia and radiation. Electron microscopic examination of the treated tumors confirmed the synergistic killing effect of the combined treatment.

Animals↗
PubMed1987

Sensitivity and recovery of stromal progenitor cells (CFU-F) in mouse bone marrow given gamma-irradiation at 0.65 Gy per day.

The sensitivity of stromal progenitor cells (CFU-F) in mouse marrow to whole-body 60Co gamma-irradiation delivered at 0.65 Gy per day, was characterised by a D0 value of about 2.5 Gy up to an accumulated dose of 5 Gy. The cells were less sensitive to higher doses. The rate of recovery following irradiation for 14 days (9.1 Gy) was less than the rate after 30 days irradiation (19.5 Gy). The latter rate of recovery approached that of the stem cells (CFU-S). At 9-10 months after either dose of irradiation, recovery of both CFU-F and CFU-S was incomplete at 30-70% of the aged control.

Animals↗
PubMed1987

[Indication of radical surgery (R2, R3) based upon the pattern of lymph node metastasis from gastric cancer].

From Jan. 1980 to June. 1984, radical operation was performed in 156 patients with gastric cancer according to the "protocol" introduced by the Gastric Cancer Research Society of Japan. There were 24 early and 132 advanced gastric cancers. Seventy patients were treated by type R2, 86 by R+2 and R3. Radical distal subtotal gastrectomy was done in 116, proximal subtotal gastrectomy in 7, simple total gastrectomy in 13 and subtotal or total gastrectomy combined with neighbouring organ resection in 20. According to TNM staging, 24 (15.4%) lesions were stage I, 9 (5.8%) stage II, 100 (64.1%) stage III and 23 (14.7%) stage IV. Twenty four lesions were within the mucosa or submucosal layer, 11 in proprius muscle layer, 18 to subserosa, 15 to serosa, 46 beyond serosa, 42 involving the surrounding organs. Lymph node metastatic rate was 66% (103 cases), metastatic degree was 21.5% (558/2593). The metastatic degree of lymph node line I, II and III was 24.7%, 20% and 8.3%, respectively. Basing on lymph node metastatic rate and degree as well as the line degree, it is proposed that, in the early stage of gastric cancer, type R1 be performed for cancer limited to the mucosa, especially the minute type, R2 for cancer invading the submucosa, in which, R+2 be indicated for some isolated patients. In the advanced gastric cancer, type R+2 be performed in the majority of patients and R3 in a few. R3 or total gastrectomy combined with neighbouring organ resection be carried out only in a part of cases with the limited type infiltrating beyond the serosa or invading the neighbouring organs.

Gastrectomy↗
PubMed1985

Thermal sensitivity of haemopoietic and stromal progenitor cells in different proliferative states.

Stromal progenitor cells (CFU-F) in normal mouse bone marrow were more sensitive to heat at 43 degrees C than haemopoietic progenitor cells (CFU-S and GM-CFC) by a factor of approximately 1.2. In marrow regenerating after 4.5 Gy X-rays, the changes in sensitivity were by less than a factor of 1.4 and the sensitivity of CFU-F changed slightly to become intermediate between that of CFU-S and GM-CFC. A comparison of sensitivities reported in the literature revealed an inexplicable large variation of up to a factor of 6 in the thermal sensitivities of CFU-S and GM-CFC.

Animals↗
PubMed1984

Greater sparing of stromal progenitor cells than of haemopoietic stem cells in gamma-irradiated mouse marrow using low dose-rates.

The Do value for fibroblastoid colony-forming units in mouse bone-marrow increased from 1.7 Gy using gamma-rays at 4.2 Gy/minute, to 2.6 Gy at 4.5 cGy/minute. In contrast, the sensitivity of bone-marrow stem cells was very little changed (Do approximately equal to 0.9 Gy). At 7.5 Gy acute single dose, the dose sparing achieved for CFU-F using 4.5 cGy/minute was a factor of 1.4, in between the values reported for lung of 1.8 and for haemopoiesis of 1.2. Although the role of CFU-F in the haemopoietic environment has not been established, the content of CFU-F can predict the ability of irradiated marrow to sustain haemopoiesis in the long term. Hence the data imply that the haemopoietic environment, as well as the dose-limiting lung, benefits from the use of low dose-rates for haemopoietic ablations in the treatment of leukaemia. No significant further sparing of CFU-F was achieved using a lower dose-rate of 1.4 cGy per minute.

Animals↗